Geriatric Nutritional Risk Index, a simplified nutritional screening index, is a significant predictor of mortality in chronic dialysis patients
Background. Malnutrition is a common complication in haemodialysis patients. Recently, the Geriatric Nutritional Risk Index (GNRI) has been reported as a simple and accurate tool to assess nutritional status of haemodialysis patients. Our objective was to examine the association between GNRI and mor...
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| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2010-10, Vol.25 (10), p.3361-3365 |
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| container_title | Nephrology, dialysis, transplantation |
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| creator | Kobayashi, Ikue Ishimura, Eiji Kato, Yoko Okuno, Senji Yamamoto, Tadashi Yamakawa, Tomoyuki Mori, Katsuhito Inaba, Masaaki Nishizawa, Yoshiki |
| description | Background. Malnutrition is a common complication in haemodialysis patients. Recently, the Geriatric Nutritional Risk Index (GNRI) has been reported as a simple and accurate tool to assess nutritional status of haemodialysis patients. Our objective was to examine the association between GNRI and mortality in chronic haemodialysis patients. Methods. We examined the GNRI of 490 maintenance haemodialysis patients (60 ± 12 years, 293 males and 197 females) and followed up these patients for 60 months. Predictors for all-cause death were examined using Kaplan–Meier analysis and Cox proportional analyses. Results. The GNRI was 98.0 ± 6.0, and was significantly and negatively correlated with age and haemodialysis duration. During the 60-month follow-up period, 129 patients died. According to the highest positive likelihood and risk ratios, the cutoff value of GNRI for mortality was set at 90. Kaplan–Meier analysis revealed that patients with a GNRI |
| doi_str_mv | 10.1093/ndt/gfq211 |
| format | Article |
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Malnutrition is a common complication in haemodialysis patients. Recently, the Geriatric Nutritional Risk Index (GNRI) has been reported as a simple and accurate tool to assess nutritional status of haemodialysis patients. Our objective was to examine the association between GNRI and mortality in chronic haemodialysis patients. Methods. We examined the GNRI of 490 maintenance haemodialysis patients (60 ± 12 years, 293 males and 197 females) and followed up these patients for 60 months. Predictors for all-cause death were examined using Kaplan–Meier analysis and Cox proportional analyses. Results. The GNRI was 98.0 ± 6.0, and was significantly and negatively correlated with age and haemodialysis duration. During the 60-month follow-up period, 129 patients died. According to the highest positive likelihood and risk ratios, the cutoff value of GNRI for mortality was set at 90. Kaplan–Meier analysis revealed that patients with a GNRI <90 (n = 50) had a significantly lower survival rate, compared to those with GNRI ≥90 (n = 440) (log-rank test, P < 0.0001). Multivariate Cox proportional hazards analyses demonstrated that GNRI was a significant predictor for mortality [hazard ratio (HR) 0.962, 95% confidence interval (CI) 0.931–0.995, P < 0.05], after adjustment for age, gender, C-reactive protein, presence of diabetes and haemodialysis duration. Conclusions. These results demonstrated that GNRI is a significant predictor for mortality in haemodialysis patients. The simple method of GNRI is considered to be a clinically useful marker for the assessment of nutritional status in haemodialysis patients.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfq211</identifier><identifier>PMID: 20400447</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Emergency and intensive care: renal failure. Dialysis management ; Female ; Geriatric Nutritional Risk Index ; Glomerulonephritis ; haemodialysis ; Humans ; Intensive care medicine ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - therapy ; Male ; malnutrition ; Malnutrition - diagnosis ; Medical sciences ; Middle Aged ; mortality ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Nutritional Status ; Proportional Hazards Models ; Renal Dialysis - mortality ; Survival Rate</subject><ispartof>Nephrology, dialysis, transplantation, 2010-10, Vol.25 (10), p.3361-3365</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-b42264b1811dd83b39c8cfe8028c592fda8df2230a4a470c803c5b15ef2b26bb3</citedby><cites>FETCH-LOGICAL-c452t-b42264b1811dd83b39c8cfe8028c592fda8df2230a4a470c803c5b15ef2b26bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23360494$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20400447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kobayashi, Ikue</creatorcontrib><creatorcontrib>Ishimura, Eiji</creatorcontrib><creatorcontrib>Kato, Yoko</creatorcontrib><creatorcontrib>Okuno, Senji</creatorcontrib><creatorcontrib>Yamamoto, Tadashi</creatorcontrib><creatorcontrib>Yamakawa, Tomoyuki</creatorcontrib><creatorcontrib>Mori, Katsuhito</creatorcontrib><creatorcontrib>Inaba, Masaaki</creatorcontrib><creatorcontrib>Nishizawa, Yoshiki</creatorcontrib><title>Geriatric Nutritional Risk Index, a simplified nutritional screening index, is a significant predictor of mortality in chronic dialysis patients</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><description>Background. Malnutrition is a common complication in haemodialysis patients. Recently, the Geriatric Nutritional Risk Index (GNRI) has been reported as a simple and accurate tool to assess nutritional status of haemodialysis patients. Our objective was to examine the association between GNRI and mortality in chronic haemodialysis patients. Methods. We examined the GNRI of 490 maintenance haemodialysis patients (60 ± 12 years, 293 males and 197 females) and followed up these patients for 60 months. Predictors for all-cause death were examined using Kaplan–Meier analysis and Cox proportional analyses. Results. The GNRI was 98.0 ± 6.0, and was significantly and negatively correlated with age and haemodialysis duration. During the 60-month follow-up period, 129 patients died. According to the highest positive likelihood and risk ratios, the cutoff value of GNRI for mortality was set at 90. Kaplan–Meier analysis revealed that patients with a GNRI <90 (n = 50) had a significantly lower survival rate, compared to those with GNRI ≥90 (n = 440) (log-rank test, P < 0.0001). Multivariate Cox proportional hazards analyses demonstrated that GNRI was a significant predictor for mortality [hazard ratio (HR) 0.962, 95% confidence interval (CI) 0.931–0.995, P < 0.05], after adjustment for age, gender, C-reactive protein, presence of diabetes and haemodialysis duration. Conclusions. These results demonstrated that GNRI is a significant predictor for mortality in haemodialysis patients. The simple method of GNRI is considered to be a clinically useful marker for the assessment of nutritional status in haemodialysis patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>Geriatric Nutritional Risk Index</subject><subject>Glomerulonephritis</subject><subject>haemodialysis</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>malnutrition</subject><subject>Malnutrition - diagnosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>mortality</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Nutritional Status</subject><subject>Proportional Hazards Models</subject><subject>Renal Dialysis - mortality</subject><subject>Survival Rate</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0cluFDEQBmALgcgQuPAAyBeEhGjitZcjGkESZVgVJMTFcnsZinS7O7ZHyrwFj4yhh8CNUx3qq0X6EXpMyUtKOn4SbD7Z-mtG6R20oqImFeOtvItWpUkrIkl3hB6k9J0Q0rGmuY-OGBGECNGs0I9TF0HnCAa_25WSYQp6wJ8gXeHzYN3NC6xxgnEewIOzOPyDkonOBQhbDIuE9BtvQ7FGh4zn6CyYPEU8eTxOMesB8r5wbL7FKZSjFvSwT2Vw1hlcyOkhuuf1kNyjQz1Gn9-8vlyfVZv3p-frV5vKCMly1QvGatHTllJrW97zzrTGu5aw1siOeatb6xnjRAstGmJawo3sqXSe9azue36Mni175zhd71zKaoRk3DDo4KZdUp0UshF13fxXNlLShteUF_l8kSZOKUXn1Rxh1HGvKFG_olIlKrVEVfCTw9pdPzp7S_9kU8DTA9DJ6MFHHQykv47zmohOFFctDlJ2N7d9Ha9U-b6R6uzLV_WWrD9cfLy4VBv-E4uLrxY</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Kobayashi, Ikue</creator><creator>Ishimura, Eiji</creator><creator>Kato, Yoko</creator><creator>Okuno, Senji</creator><creator>Yamamoto, Tadashi</creator><creator>Yamakawa, Tomoyuki</creator><creator>Mori, Katsuhito</creator><creator>Inaba, Masaaki</creator><creator>Nishizawa, Yoshiki</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20101001</creationdate><title>Geriatric Nutritional Risk Index, a simplified nutritional screening index, is a significant predictor of mortality in chronic dialysis patients</title><author>Kobayashi, Ikue ; Ishimura, Eiji ; Kato, Yoko ; Okuno, Senji ; Yamamoto, Tadashi ; Yamakawa, Tomoyuki ; Mori, Katsuhito ; Inaba, Masaaki ; Nishizawa, Yoshiki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-b42264b1811dd83b39c8cfe8028c592fda8df2230a4a470c803c5b15ef2b26bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>Geriatric Nutritional Risk Index</topic><topic>Glomerulonephritis</topic><topic>haemodialysis</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>malnutrition</topic><topic>Malnutrition - diagnosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>mortality</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Nutritional Status</topic><topic>Proportional Hazards Models</topic><topic>Renal Dialysis - mortality</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kobayashi, Ikue</creatorcontrib><creatorcontrib>Ishimura, Eiji</creatorcontrib><creatorcontrib>Kato, Yoko</creatorcontrib><creatorcontrib>Okuno, Senji</creatorcontrib><creatorcontrib>Yamamoto, Tadashi</creatorcontrib><creatorcontrib>Yamakawa, Tomoyuki</creatorcontrib><creatorcontrib>Mori, Katsuhito</creatorcontrib><creatorcontrib>Inaba, Masaaki</creatorcontrib><creatorcontrib>Nishizawa, Yoshiki</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kobayashi, Ikue</au><au>Ishimura, Eiji</au><au>Kato, Yoko</au><au>Okuno, Senji</au><au>Yamamoto, Tadashi</au><au>Yamakawa, Tomoyuki</au><au>Mori, Katsuhito</au><au>Inaba, Masaaki</au><au>Nishizawa, Yoshiki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Geriatric Nutritional Risk Index, a simplified nutritional screening index, is a significant predictor of mortality in chronic dialysis patients</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>25</volume><issue>10</issue><spage>3361</spage><epage>3365</epage><pages>3361-3365</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>Background. Malnutrition is a common complication in haemodialysis patients. Recently, the Geriatric Nutritional Risk Index (GNRI) has been reported as a simple and accurate tool to assess nutritional status of haemodialysis patients. Our objective was to examine the association between GNRI and mortality in chronic haemodialysis patients. Methods. We examined the GNRI of 490 maintenance haemodialysis patients (60 ± 12 years, 293 males and 197 females) and followed up these patients for 60 months. Predictors for all-cause death were examined using Kaplan–Meier analysis and Cox proportional analyses. Results. The GNRI was 98.0 ± 6.0, and was significantly and negatively correlated with age and haemodialysis duration. During the 60-month follow-up period, 129 patients died. According to the highest positive likelihood and risk ratios, the cutoff value of GNRI for mortality was set at 90. Kaplan–Meier analysis revealed that patients with a GNRI <90 (n = 50) had a significantly lower survival rate, compared to those with GNRI ≥90 (n = 440) (log-rank test, P < 0.0001). Multivariate Cox proportional hazards analyses demonstrated that GNRI was a significant predictor for mortality [hazard ratio (HR) 0.962, 95% confidence interval (CI) 0.931–0.995, P < 0.05], after adjustment for age, gender, C-reactive protein, presence of diabetes and haemodialysis duration. Conclusions. These results demonstrated that GNRI is a significant predictor for mortality in haemodialysis patients. The simple method of GNRI is considered to be a clinically useful marker for the assessment of nutritional status in haemodialysis patients.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>20400447</pmid><doi>10.1093/ndt/gfq211</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Emergency and intensive care: renal failure. Dialysis management Female Geriatric Nutritional Risk Index Glomerulonephritis haemodialysis Humans Intensive care medicine Kidney Failure, Chronic - complications Kidney Failure, Chronic - therapy Male malnutrition Malnutrition - diagnosis Medical sciences Middle Aged mortality Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Nutritional Status Proportional Hazards Models Renal Dialysis - mortality Survival Rate |
| title | Geriatric Nutritional Risk Index, a simplified nutritional screening index, is a significant predictor of mortality in chronic dialysis patients |
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