Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/γcnull mouse

Mounting evidence has demonstrated that NOD-Shi/scid/γc(null) (NOG) mice are one of the most suitable mouse strains for humanized mouse technologies, in which various human cells or tissues can be engrafted without rejection and autonomously maintained. We have characterized and analyzed various fea...

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Veröffentlicht in:	International immunology 2012-04, Vol.24 (4), p.243-252
Hauptverfasser:	Suzuki, Makiko, Takahashi, Takeshi, Katano, Ikumi, Ito, Ryoji, Ito, Mamoru, Harigae, Hideo, Ishii, Naoto, Sugamura, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD34 - analysis Cells, Cultured Female Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - immunology Hematopoietic Stem Cells - metabolism HLA-DR4 Antigen - genetics HLA-DR4 Antigen - immunology HLA-DRB1 Chains - genetics HLA-DRB1 Chains - immunology Humans Immunity, Humoral Immunoglobulin Class Switching Lymphocyte Activation Mice Mice, Inbred NOD Mice, SCID Mice, Transgenic T-Lymphocytes - immunology T-Lymphocytes - metabolism Transplantation, Heterologous
Online-Zugang:	Volltext
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