Both activating and inhibitory Fc gamma receptors mediate rituximab-induced trogocytosis of CD20 in mice

Highlights ► The role of FcγR in rituximab-induced trogocytosis of CD20 was studied in mice. ► We found redundant role for activating mouse FcγR in trogocytosis of CD20. ► The inhibitory FcγRIIB could also mediate in trogocytosis. ► Loss of CD20 impaired subsequent complement mediated killing ex viv...

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Veröffentlicht in:	Immunology letters 2012-03, Vol.143 (1), p.44-52
Hauptverfasser:	Boross, Peter, Jansen, J.H. Marco, Pastula, Agnieszka, van der Poel, Cees E, Leusen, Jeanette H.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Monoclonal, Murine-Derived - immunology Antigens, CD20 - immunology Apoptosis CD20 Cell Line, Tumor Fc receptor Humans Immunological Synapses - immunology Macrophages - immunology Mice Mice, Inbred C57BL Neoplasms - immunology Neoplasms - pathology Receptors, IgG - immunology Rituximab Trogocytosis
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Beschreibung
Zusammenfassung:	Highlights ► The role of FcγR in rituximab-induced trogocytosis of CD20 was studied in mice. ► We found redundant role for activating mouse FcγR in trogocytosis of CD20. ► The inhibitory FcγRIIB could also mediate in trogocytosis. ► Loss of CD20 impaired subsequent complement mediated killing ex vivo . ► Lowering rituximab dose may prevent trogocytosis while preserving anti-tumor effect.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2012.01.004