Block of Na+ currents and suppression of action potentials in embryonic rat dorsal root ganglion neurons by ranolazine

Ranolazine, an anti-anginal drug, reduces neuropathic and inflammatory-induced allodynia in rats. However, the mechanism of ranolazin's anti-allodynic effect is not known. We hypothesized that ranolazine would reduce dorsal root ganglion (DRG) Na+ current (INa) and neuronal firing by stabilizin...

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Veröffentlicht in:	Neuropharmacology 2012-06, Vol.62 (7), p.2250-2259
Hauptverfasser:	Hirakawa, Ryoko, El-Bizri, Nesrine, Shryock, John C., Belardinelli, Luiz, Rajamani, Sridharan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetanilides - pharmacology Action potential Action Potentials - drug effects Action Potentials - physiology Animal models Animals Cells, Cultured Dorsal root ganglia Dorsal root ganglion Drugs Embryos Firing rate Frequency dependence Ganglia, Spinal - drug effects Ganglia, Spinal - embryology Ganglia, Spinal - physiology HEK293 Cells Humans Membrane potential NAV1.3 Voltage-Gated Sodium Channel - physiology Neurons Neuropathic pain Neuropathy Pain perception Piperazines - pharmacology Ranolazine Rats Sodium channel Sodium Channel Blockers - pharmacology Sodium channels Sodium channels (voltage-gated) Sodium Channels - physiology Tetrodotoxin
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