Multifunctional stable fluorescent magnetic nanoparticles
Because of their multifunctionality and unique magnetic properties, superparamagnetic iron oxide nanoparticles (SPIONs) have been recognized as very promising materials for various biomedical applications. The main difficulty with the use of SPIONs as multimodal bioimaging agents is their lack of fl...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2012-04, Vol.48 (33), p.3957-3959 |
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| container_issue | 33 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Mahmoudi, Morteza Shokrgozar, Mohammad A |
| description | Because of their multifunctionality and unique magnetic properties, superparamagnetic iron oxide nanoparticles (SPIONs) have been recognized as very promising materials for various biomedical applications. The main difficulty with the use of SPIONs as multimodal bioimaging agents is their lack of fluorescence. Since cells can act as extremely efficient filters for the elution of surface-bound fluorescent tags with nanoparticles, the surface loaded fluorescence dyes significantly decay after a short period of time. Here, for the first time, we introduce novel, engineered multimodal SPIONs with a permanent fluorescence capability, the study of which can lead to a deeper understanding of biological processes at the biomolecular level, greatly influencing molecular diagnostics, imaging and therapeutic applications. |
| doi_str_mv | 10.1039/c2cc30213f |
| format | Article |
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| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2012-04, Vol.48 (33), p.3957-3959 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biomedical materials Decay Dyes Ferric Compounds - chemistry Fluorescence Fluorescent Dyes - chemistry Gold - chemistry Iron oxides Magnetic properties Magnets - chemistry Models, Molecular Molecular Conformation Nanoparticles Nanoparticles - chemistry Polymers - chemistry Tags |
| title | Multifunctional stable fluorescent magnetic nanoparticles |
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