The HIF1 target gene NOX2 promotes angiogenesis through urotensin-II

Urotensin-II (U-II) has been considered as one of the most potent vasoactive peptides, although its physiological and pathophysiological role is still not finally resolved. Recent evidence suggests that it promotes angiogenic responses in endothelial cells, although the underlying signalling mechani...

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Veröffentlicht in:	Journal of cell science 2012-02, Vol.125 (Pt 4), p.956-964
Hauptverfasser:	Diebold, Isabel, Petry, Andreas, Sabrane, Karim, Djordjevic, Talija, Hess, John, Görlach, Agnes
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Feedback, Physiological HEK293 Cells Human Umbilical Vein Endothelial Cells Humans Hypoxia-Inducible Factor 1 - metabolism Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - deficiency Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice NADPH Oxidase 2 NADPH Oxidases - biosynthesis NADPH Oxidases - deficiency NADPH Oxidases - genetics NADPH Oxidases - metabolism Neovascularization, Pathologic Neovascularization, Physiologic - drug effects Reactive Oxygen Species - metabolism Receptors, G-Protein-Coupled - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Up-Regulation - drug effects Urotensins - metabolism Urotensins - pharmacology
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