The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo

The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) defines a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF). Here, we describe a LEM protein annotated in data...

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Veröffentlicht in:	Journal of cell science 2012-02, Vol.125 (Pt 4), p.1048-1057
Hauptverfasser:	Brachner, Andreas, Braun, Juliane, Ghodgaonkar, Medini, Castor, Dennis, Zlopasa, Livija, Ehrlich, Veronika, Jiricny, Josef, Gotzmann, Josef, Knasmüller, Siegfried, Foisner, Roland
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Cell Line Cell Nucleus - metabolism Conserved Sequence Cytoplasm - metabolism DNA Cleavage DNA Damage Endonucleases - analysis Endonucleases - chemistry Endonucleases - genetics Endonucleases - metabolism Gene Expression Profiling Hematopoietic System - metabolism Humans Immunoprecipitation Metazoa Organ Specificity Polymerase Chain Reaction Protein Structure, Tertiary Protein Transport Signal Transduction
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