$Induction of the early inflammatory-mediated cellular responses of fracture healing in vitro using platelet releasate-containing alginate/CaPO4 biomaterials for early osteoarthritis prevention$

Induction of the early inflammatory-mediated cellular responses of fracture healing in vitro using platelet releasate-containing alginate/CaPO4 biomaterials for early osteoarthritis prevention

A significant gap exists in our understanding of subchondral and cancellous bone changes that may regulate osteoarthritis progression. Herein, we complement our prior osteochondrogenesis work with growth factor elution and monocyte and endothelial cell activation using two biomaterial formulations....

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Veröffentlicht in:	Journal of biomedical materials research. Part A 2012-05, Vol.100A (5), p.1107-1114
Hauptverfasser:	McCanless, Jonathan D., Jennings, Lisa K., Cole, Judith A., Bumgardner, Joel D., Haggard, Warren O.
Format:	Artikel
Sprache:	eng
Schlagworte:	alginate Alginates - pharmacology Animals Biocompatible Materials - pharmacology Biological and medical sciences Blood Platelets - drug effects Blood Platelets - metabolism Calcium Phosphates - pharmacology Cell Line Cell Movement - drug effects Diseases of the osteoarticular system Enzyme-Linked Immunosorbent Assay Fracture Healing - drug effects Glucuronic Acid - pharmacology Hexuronic Acids - pharmacology human umbilical vein endothelial cells Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - drug effects Humans Inflammation - complications Inflammation - pathology Injuries of the limb. Injuries of the spine Medical sciences Mice monocyte Monocytes - cytology Monocytes - drug effects Neovascularization, Physiologic - drug effects Osteoarthritis Osteoarthritis - complications Osteoarthritis - pathology Osteoarthritis - prevention & control platelet releasate Platelet-Derived Growth Factor - pharmacology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Traumas. Diseases due to physical agents tricalcium phosphate
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