Estimation of rate constants of drug binding to open channels of cardiac transient outward current

An improved approach to the evaluation of the rate constants of drugs binding to the open channel underlying the transient outward potassium current I(t0) is described. It is based on an analysis of a quantitative model formulated by a set of twelve differential equations. The rate constants are cal...

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Veröffentlicht in:	General physiology and biophysics 2012-03, Vol.31 (1), p.113-116
Hauptverfasser:	Simurda, Jiří, Simurdová, Milena
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Cell Membrane - drug effects Cell Membrane - physiology Computer Simulation Ion Channel Gating - drug effects Ion Channel Gating - physiology Kinetics Membrane Potentials - physiology Models, Cardiovascular Myocytes, Cardiac - drug effects Myocytes, Cardiac - physiology Potassium - metabolism Potassium Channel Blockers - pharmacology Potassium Channels - drug effects Potassium Channels - physiology
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