An exploratory study of the influence of clinico-demographic variables on swallowing and swallowing-related quality of life in a cohort of oral and oropharyngeal cancer patients treated with primary surgery
There are insufficient data on swallowing and the consequences of its dysfunction in patients with cancers of the oral cavity (OC) and oropharynx (OP) that are treated with primary surgery. The study attempts to explore the effect of important clinico-demographic variables on post-treatment swallowi...
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| Veröffentlicht in: | European archives of oto-rhino-laryngology 2012-04, Vol.269 (4), p.1233-1239 |
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| creator | Dwivedi, Raghav C. Chisholm, Edward J. Khan, Afroze S. Harris, Nicholas J. Bhide, Shree A. St.Rose, Suzanne Kerawala, Cyrus J. Clarke, Peter M. Nutting, Christopher M. Rhys-Evans, Peter H. Harrington, Kevin J. Kazi, Rehan |
| description | There are insufficient data on swallowing and the consequences of its dysfunction in patients with cancers of the oral cavity (OC) and oropharynx (OP) that are treated with primary surgery. The study attempts to explore the effect of important clinico-demographic variables on post-treatment swallowing and related quality of life (QOL) in post-surgical OC and OP cancer patients. Sixty-two consecutive OC and OP cancer patients completed the MD Anderson Dysphagia Inventory (MDADI) questionnaire. Mean scores were computed. Comparison of scores based on mean ranks were performed using Mann–Whitney
U
test or Kruskal–Wallis test. Level of significance was set at
P
≤ 0.02. Adjustments were made for multiple comparisons. Significantly worse mean (SD) QOL scores were observed in late T-stage (T3/T4) versus early T-stage (T1/T2) patients for global domain, physical domain, functional domain and emotional domains [44.4 (21.9) vs. 78.7 (22.7) (
P
|
| doi_str_mv | 10.1007/s00405-011-1756-y |
| format | Article |
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U
test or Kruskal–Wallis test. Level of significance was set at
P
≤ 0.02. Adjustments were made for multiple comparisons. Significantly worse mean (SD) QOL scores were observed in late T-stage (T3/T4) versus early T-stage (T1/T2) patients for global domain, physical domain, functional domain and emotional domains [44.4 (21.9) vs. 78.7 (22.7) (
P
< 0.001); 50.0 (9.4) vs. 75.9 (16.3), (
P
< 0.0001); 57.8 (20.6) vs. 84.1 (16.7), (
P
< 0.001) and 55.2 (18.0) vs. 78.5 (16.3), (
P
< 0.001)], respectively. Patients undergoing reconstruction versus without reconstruction had worse QOL scores; 58.8 (26.9) versus 79.5 (22.8), (
P
< 0.01); 61.2 (15.1) versus 76.4 (17.5), (
P
= 0.002); 65.4 (20.5) versus 86.3 (15.9), (
P
< 0.0001) and 63.3 (18.8) versus 79.8 (16.3), (
P
< 0.01), respectively, for global, physical, functional and emotional domains. Advanced T-stage, reconstruction, younger age and base of tongue tumours have a negative impact on post-treatment swallow function and related QOL in these patients.]]></description><identifier>ISSN: 0937-4477</identifier><identifier>EISSN: 1434-4726</identifier><identifier>DOI: 10.1007/s00405-011-1756-y</identifier><identifier>PMID: 21909656</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Deglutition - physiology ; Female ; Head and Neck ; Head and Neck Surgery ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mouth Neoplasms - physiopathology ; Mouth Neoplasms - psychology ; Mouth Neoplasms - surgery ; Neurosurgery ; Oral Surgical Procedures - methods ; Oropharyngeal Neoplasms - physiopathology ; Oropharyngeal Neoplasms - psychology ; Oropharyngeal Neoplasms - surgery ; Otorhinolaryngology ; Quality of Life ; Surveys and Questionnaires</subject><ispartof>European archives of oto-rhino-laryngology, 2012-04, Vol.269 (4), p.1233-1239</ispartof><rights>Springer-Verlag 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c273t-3307ed608bf28dc2f0a0c04367939cbd814dd78fff5f95b7e9ad56da49c0e0cc3</citedby><cites>FETCH-LOGICAL-c273t-3307ed608bf28dc2f0a0c04367939cbd814dd78fff5f95b7e9ad56da49c0e0cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00405-011-1756-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00405-011-1756-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21909656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dwivedi, Raghav C.</creatorcontrib><creatorcontrib>Chisholm, Edward J.</creatorcontrib><creatorcontrib>Khan, Afroze S.</creatorcontrib><creatorcontrib>Harris, Nicholas J.</creatorcontrib><creatorcontrib>Bhide, Shree A.</creatorcontrib><creatorcontrib>St.Rose, Suzanne</creatorcontrib><creatorcontrib>Kerawala, Cyrus J.</creatorcontrib><creatorcontrib>Clarke, Peter M.</creatorcontrib><creatorcontrib>Nutting, Christopher M.</creatorcontrib><creatorcontrib>Rhys-Evans, Peter H.</creatorcontrib><creatorcontrib>Harrington, Kevin J.</creatorcontrib><creatorcontrib>Kazi, Rehan</creatorcontrib><title>An exploratory study of the influence of clinico-demographic variables on swallowing and swallowing-related quality of life in a cohort of oral and oropharyngeal cancer patients treated with primary surgery</title><title>European archives of oto-rhino-laryngology</title><addtitle>Eur Arch Otorhinolaryngol</addtitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><description><![CDATA[There are insufficient data on swallowing and the consequences of its dysfunction in patients with cancers of the oral cavity (OC) and oropharynx (OP) that are treated with primary surgery. The study attempts to explore the effect of important clinico-demographic variables on post-treatment swallowing and related quality of life (QOL) in post-surgical OC and OP cancer patients. Sixty-two consecutive OC and OP cancer patients completed the MD Anderson Dysphagia Inventory (MDADI) questionnaire. Mean scores were computed. Comparison of scores based on mean ranks were performed using Mann–Whitney
U
test or Kruskal–Wallis test. Level of significance was set at
P
≤ 0.02. Adjustments were made for multiple comparisons. Significantly worse mean (SD) QOL scores were observed in late T-stage (T3/T4) versus early T-stage (T1/T2) patients for global domain, physical domain, functional domain and emotional domains [44.4 (21.9) vs. 78.7 (22.7) (
P
< 0.001); 50.0 (9.4) vs. 75.9 (16.3), (
P
< 0.0001); 57.8 (20.6) vs. 84.1 (16.7), (
P
< 0.001) and 55.2 (18.0) vs. 78.5 (16.3), (
P
< 0.001)], respectively. Patients undergoing reconstruction versus without reconstruction had worse QOL scores; 58.8 (26.9) versus 79.5 (22.8), (
P
< 0.01); 61.2 (15.1) versus 76.4 (17.5), (
P
= 0.002); 65.4 (20.5) versus 86.3 (15.9), (
P
< 0.0001) and 63.3 (18.8) versus 79.8 (16.3), (
P
< 0.01), respectively, for global, physical, functional and emotional domains. Advanced T-stage, reconstruction, younger age and base of tongue tumours have a negative impact on post-treatment swallow function and related QOL in these patients.]]></description><subject>Deglutition - physiology</subject><subject>Female</subject><subject>Head and Neck</subject><subject>Head and Neck Surgery</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - physiopathology</subject><subject>Mouth Neoplasms - psychology</subject><subject>Mouth Neoplasms - surgery</subject><subject>Neurosurgery</subject><subject>Oral Surgical Procedures - methods</subject><subject>Oropharyngeal Neoplasms - physiopathology</subject><subject>Oropharyngeal Neoplasms - psychology</subject><subject>Oropharyngeal Neoplasms - surgery</subject><subject>Otorhinolaryngology</subject><subject>Quality of Life</subject><subject>Surveys and Questionnaires</subject><issn>0937-4477</issn><issn>1434-4726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhSMEotPCA7BB3rEK3CROHC-rij-pEhtYW459PXHlsVPbYchL9plIZgbEipXl63M-netTFG8qeF8BsA8JgEJbQlWVFWu7cnlW7Cra0JKyunte7IA3rKSUsaviOqUHAGgpb14WV3XFgXdttyuebj3BX5MLUeYQF5LyrBcSDMkjEuuNm9Er3AbKWW9VKDUewj7KabSK_JTRysFhIsGTdJTOhaP1eyK9_udaRnQyoyaPs3Q2n_DOmo1PJFFhDDFvszWDO1lDDNMo4-L3uE6UXBNEMsls0edEcsQT7WjzSKZoD3LLPcc9xuVV8cJIl_D15bwpfnz6-P3uS3n_7fPXu9v7UtWsyWXTAEPdQT-YuteqNiBBAW06xhuuBt1XVGvWG2Naw9uBIZe67bSkXAGCUs1N8e7MnWJ4nDFlcbBJoXPSY5iT4LTn0NCuXZXVWaliSCmiEZfIogKxtSjOLYq1RbG1KJbV8_ZCn4cD6r-OP7WtgvosSOvT-ktRPIQ5-nXj_1B_A_00r5o</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Dwivedi, Raghav C.</creator><creator>Chisholm, Edward J.</creator><creator>Khan, Afroze S.</creator><creator>Harris, Nicholas J.</creator><creator>Bhide, Shree A.</creator><creator>St.Rose, Suzanne</creator><creator>Kerawala, Cyrus J.</creator><creator>Clarke, Peter M.</creator><creator>Nutting, Christopher M.</creator><creator>Rhys-Evans, Peter H.</creator><creator>Harrington, Kevin J.</creator><creator>Kazi, Rehan</creator><general>Springer-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120401</creationdate><title>An exploratory study of the influence of clinico-demographic variables on swallowing and swallowing-related quality of life in a cohort of oral and oropharyngeal cancer patients treated with primary surgery</title><author>Dwivedi, Raghav C. ; Chisholm, Edward J. ; Khan, Afroze S. ; Harris, Nicholas J. ; Bhide, Shree A. ; St.Rose, Suzanne ; Kerawala, Cyrus J. ; Clarke, Peter M. ; Nutting, Christopher M. ; Rhys-Evans, Peter H. ; Harrington, Kevin J. ; Kazi, Rehan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c273t-3307ed608bf28dc2f0a0c04367939cbd814dd78fff5f95b7e9ad56da49c0e0cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Deglutition - physiology</topic><topic>Female</topic><topic>Head and Neck</topic><topic>Head and Neck Surgery</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - physiopathology</topic><topic>Mouth Neoplasms - psychology</topic><topic>Mouth Neoplasms - surgery</topic><topic>Neurosurgery</topic><topic>Oral Surgical Procedures - methods</topic><topic>Oropharyngeal Neoplasms - physiopathology</topic><topic>Oropharyngeal Neoplasms - psychology</topic><topic>Oropharyngeal Neoplasms - surgery</topic><topic>Otorhinolaryngology</topic><topic>Quality of Life</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dwivedi, Raghav C.</creatorcontrib><creatorcontrib>Chisholm, Edward J.</creatorcontrib><creatorcontrib>Khan, Afroze S.</creatorcontrib><creatorcontrib>Harris, Nicholas J.</creatorcontrib><creatorcontrib>Bhide, Shree A.</creatorcontrib><creatorcontrib>St.Rose, Suzanne</creatorcontrib><creatorcontrib>Kerawala, Cyrus J.</creatorcontrib><creatorcontrib>Clarke, Peter M.</creatorcontrib><creatorcontrib>Nutting, Christopher M.</creatorcontrib><creatorcontrib>Rhys-Evans, Peter H.</creatorcontrib><creatorcontrib>Harrington, Kevin J.</creatorcontrib><creatorcontrib>Kazi, Rehan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of oto-rhino-laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dwivedi, Raghav C.</au><au>Chisholm, Edward J.</au><au>Khan, Afroze S.</au><au>Harris, Nicholas J.</au><au>Bhide, Shree A.</au><au>St.Rose, Suzanne</au><au>Kerawala, Cyrus J.</au><au>Clarke, Peter M.</au><au>Nutting, Christopher M.</au><au>Rhys-Evans, Peter H.</au><au>Harrington, Kevin J.</au><au>Kazi, Rehan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An exploratory study of the influence of clinico-demographic variables on swallowing and swallowing-related quality of life in a cohort of oral and oropharyngeal cancer patients treated with primary surgery</atitle><jtitle>European archives of oto-rhino-laryngology</jtitle><stitle>Eur Arch Otorhinolaryngol</stitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>269</volume><issue>4</issue><spage>1233</spage><epage>1239</epage><pages>1233-1239</pages><issn>0937-4477</issn><eissn>1434-4726</eissn><abstract><![CDATA[There are insufficient data on swallowing and the consequences of its dysfunction in patients with cancers of the oral cavity (OC) and oropharynx (OP) that are treated with primary surgery. The study attempts to explore the effect of important clinico-demographic variables on post-treatment swallowing and related quality of life (QOL) in post-surgical OC and OP cancer patients. Sixty-two consecutive OC and OP cancer patients completed the MD Anderson Dysphagia Inventory (MDADI) questionnaire. Mean scores were computed. Comparison of scores based on mean ranks were performed using Mann–Whitney
U
test or Kruskal–Wallis test. Level of significance was set at
P
≤ 0.02. Adjustments were made for multiple comparisons. Significantly worse mean (SD) QOL scores were observed in late T-stage (T3/T4) versus early T-stage (T1/T2) patients for global domain, physical domain, functional domain and emotional domains [44.4 (21.9) vs. 78.7 (22.7) (
P
< 0.001); 50.0 (9.4) vs. 75.9 (16.3), (
P
< 0.0001); 57.8 (20.6) vs. 84.1 (16.7), (
P
< 0.001) and 55.2 (18.0) vs. 78.5 (16.3), (
P
< 0.001)], respectively. Patients undergoing reconstruction versus without reconstruction had worse QOL scores; 58.8 (26.9) versus 79.5 (22.8), (
P
< 0.01); 61.2 (15.1) versus 76.4 (17.5), (
P
= 0.002); 65.4 (20.5) versus 86.3 (15.9), (
P
< 0.0001) and 63.3 (18.8) versus 79.8 (16.3), (
P
< 0.01), respectively, for global, physical, functional and emotional domains. Advanced T-stage, reconstruction, younger age and base of tongue tumours have a negative impact on post-treatment swallow function and related QOL in these patients.]]></abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21909656</pmid><doi>10.1007/s00405-011-1756-y</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0937-4477 |
| ispartof | European archives of oto-rhino-laryngology, 2012-04, Vol.269 (4), p.1233-1239 |
| issn | 0937-4477 1434-4726 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Deglutition - physiology Female Head and Neck Head and Neck Surgery Humans Male Medicine Medicine & Public Health Middle Aged Mouth Neoplasms - physiopathology Mouth Neoplasms - psychology Mouth Neoplasms - surgery Neurosurgery Oral Surgical Procedures - methods Oropharyngeal Neoplasms - physiopathology Oropharyngeal Neoplasms - psychology Oropharyngeal Neoplasms - surgery Otorhinolaryngology Quality of Life Surveys and Questionnaires |
| title | An exploratory study of the influence of clinico-demographic variables on swallowing and swallowing-related quality of life in a cohort of oral and oropharyngeal cancer patients treated with primary surgery |
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