Serum and Tissue CD23, IL‐15, and FasL in Cow's‐Milk Protein–sensitive Enteropathy and in Coeliac Disease
ABSTRACT Objectives: The aim of the study was to explore pathogenesis and find new serum markers for cow's‐milk–sensitive enteropathy (CMSE) and coeliac disease (CD). We assessed the intestinal expression and serum concentration of CD23, IL‐15, and FasL. We hypothesised that the serum levels of...
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 2012-04, Vol.54 (4), p.525-531 |
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| creator | Kokkonen, Tuomo S. Augustin, Merja T. Kokkonen, Jorma Karttunen, Riitta Karttunen, Tuomo J. |
| description | ABSTRACT
Objectives:
The aim of the study was to explore pathogenesis and find new serum markers for cow's‐milk–sensitive enteropathy (CMSE) and coeliac disease (CD). We assessed the intestinal expression and serum concentration of CD23, IL‐15, and FasL. We hypothesised that the serum levels of CD23, a protein expressed in the lymphoid follicles, would be associated with lymphonodular hyperplasia (LNH), a feature characteristic of CMSE. We also presumed that interleukin (IL)‐15 and FasL, functionally connected with proliferation and apoptosis of the intraepithelial lymphocytes (IELs), would relate with the increased numbers of IELs present in both CMSE and CD.
Methods:
Twenty‐three children with CMSE, 20 with untreated CD, and 14 controls were studied for CD3, α/β‐ and γ/δ‐expressing IELs, and for duodenal and ileal expression of CD23, FasL, and IL‐15 by immunohistochemistry, and for serum concentration of sCD23, sFasL, and sIL‐15 by enzyme‐linked immunosorbent assay.
Results:
There was a trend for increase in sCD23 serum levels in untreated CMSE and in CD (P = 0.074; P = 0.077). CD23 was expressed in the mucosal germinal centres, but sCD23 was not related to presence of LNH. In CMSE, there was a trend for increase in serum sFasL (P = 0.07) and high levels associated with LNH (P = 0.025) and correlated with the IEL numbers (P < 0.05). Mucosal high endothelial venules adjacent to lymphoid follicles showed an intensive FasL expression.
Conclusions:
Serum sCD23 shows a trend of increment in CMSE and CD, and in the latter, sCD23 level may provide information about the severity of villous atrophy. In CMSE, high serum sFasL indicates both LNH and an increase of IELs, suggesting importance of FasL‐mediated mechanisms in the pathogenesis of these features characteristic of CMSE. Further studies are necessary to evaluate whether intensive FasL expression in mucosal high endothelial venules presents a regulatory element in mucosal immunity. |
| doi_str_mv | 10.1097/MPG.0b013e318237c145 |
| format | Article |
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Objectives:
The aim of the study was to explore pathogenesis and find new serum markers for cow's‐milk–sensitive enteropathy (CMSE) and coeliac disease (CD). We assessed the intestinal expression and serum concentration of CD23, IL‐15, and FasL. We hypothesised that the serum levels of CD23, a protein expressed in the lymphoid follicles, would be associated with lymphonodular hyperplasia (LNH), a feature characteristic of CMSE. We also presumed that interleukin (IL)‐15 and FasL, functionally connected with proliferation and apoptosis of the intraepithelial lymphocytes (IELs), would relate with the increased numbers of IELs present in both CMSE and CD.
Methods:
Twenty‐three children with CMSE, 20 with untreated CD, and 14 controls were studied for CD3, α/β‐ and γ/δ‐expressing IELs, and for duodenal and ileal expression of CD23, FasL, and IL‐15 by immunohistochemistry, and for serum concentration of sCD23, sFasL, and sIL‐15 by enzyme‐linked immunosorbent assay.
Results:
There was a trend for increase in sCD23 serum levels in untreated CMSE and in CD (P = 0.074; P = 0.077). CD23 was expressed in the mucosal germinal centres, but sCD23 was not related to presence of LNH. In CMSE, there was a trend for increase in serum sFasL (P = 0.07) and high levels associated with LNH (P = 0.025) and correlated with the IEL numbers (P < 0.05). Mucosal high endothelial venules adjacent to lymphoid follicles showed an intensive FasL expression.
Conclusions:
Serum sCD23 shows a trend of increment in CMSE and CD, and in the latter, sCD23 level may provide information about the severity of villous atrophy. In CMSE, high serum sFasL indicates both LNH and an increase of IELs, suggesting importance of FasL‐mediated mechanisms in the pathogenesis of these features characteristic of CMSE. Further studies are necessary to evaluate whether intensive FasL expression in mucosal high endothelial venules presents a regulatory element in mucosal immunity.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1097/MPG.0b013e318237c145</identifier><identifier>PMID: 21946835</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Copyright by ESPGHAN and NASPGHAN</publisher><subject>Adolescent ; Apoptosis ; Biological and medical sciences ; Biomarkers - blood ; Case-Control Studies ; CD23 ; Celiac Disease - blood ; Celiac Disease - complications ; Celiac Disease - pathology ; Child ; Child, Preschool ; children ; CMSE ; coeliac disease ; Duodenum - immunology ; Duodenum - pathology ; enteropathy ; Enzyme-Linked Immunosorbent Assay - methods ; Fas Ligand Protein - blood ; FasL ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; IEL ; IL‐15 ; Interleukin-15 - blood ; Intestinal Diseases - complications ; Intestinal Diseases - immunology ; Intestinal Diseases - pathology ; Lymphocyte Count ; Lymphocytes - metabolism ; Lymphocytes - pathology ; Male ; Medical sciences ; milk allergy ; Milk Hypersensitivity - blood ; Milk Hypersensitivity - complications ; Milk Hypersensitivity - immunology ; Milk Proteins - immunology ; Milk Proteins - metabolism ; Other diseases. Semiology ; Receptors, IgE - blood ; serum ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 2012-04, Vol.54 (4), p.525-531</ispartof><rights>2012 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>Copyright 2012 by ESPGHAN and NASPGHAN</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4855-83225752646af995ea53bb94cb32443e00cf82486d5b5a678a5c8b89b17503313</citedby><cites>FETCH-LOGICAL-c4855-83225752646af995ea53bb94cb32443e00cf82486d5b5a678a5c8b89b17503313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1097%2FMPG.0b013e318237c145$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1097%2FMPG.0b013e318237c145$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25654942$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21946835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kokkonen, Tuomo S.</creatorcontrib><creatorcontrib>Augustin, Merja T.</creatorcontrib><creatorcontrib>Kokkonen, Jorma</creatorcontrib><creatorcontrib>Karttunen, Riitta</creatorcontrib><creatorcontrib>Karttunen, Tuomo J.</creatorcontrib><title>Serum and Tissue CD23, IL‐15, and FasL in Cow's‐Milk Protein–sensitive Enteropathy and in Coeliac Disease</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>ABSTRACT
Objectives:
The aim of the study was to explore pathogenesis and find new serum markers for cow's‐milk–sensitive enteropathy (CMSE) and coeliac disease (CD). We assessed the intestinal expression and serum concentration of CD23, IL‐15, and FasL. We hypothesised that the serum levels of CD23, a protein expressed in the lymphoid follicles, would be associated with lymphonodular hyperplasia (LNH), a feature characteristic of CMSE. We also presumed that interleukin (IL)‐15 and FasL, functionally connected with proliferation and apoptosis of the intraepithelial lymphocytes (IELs), would relate with the increased numbers of IELs present in both CMSE and CD.
Methods:
Twenty‐three children with CMSE, 20 with untreated CD, and 14 controls were studied for CD3, α/β‐ and γ/δ‐expressing IELs, and for duodenal and ileal expression of CD23, FasL, and IL‐15 by immunohistochemistry, and for serum concentration of sCD23, sFasL, and sIL‐15 by enzyme‐linked immunosorbent assay.
Results:
There was a trend for increase in sCD23 serum levels in untreated CMSE and in CD (P = 0.074; P = 0.077). CD23 was expressed in the mucosal germinal centres, but sCD23 was not related to presence of LNH. In CMSE, there was a trend for increase in serum sFasL (P = 0.07) and high levels associated with LNH (P = 0.025) and correlated with the IEL numbers (P < 0.05). Mucosal high endothelial venules adjacent to lymphoid follicles showed an intensive FasL expression.
Conclusions:
Serum sCD23 shows a trend of increment in CMSE and CD, and in the latter, sCD23 level may provide information about the severity of villous atrophy. In CMSE, high serum sFasL indicates both LNH and an increase of IELs, suggesting importance of FasL‐mediated mechanisms in the pathogenesis of these features characteristic of CMSE. Further studies are necessary to evaluate whether intensive FasL expression in mucosal high endothelial venules presents a regulatory element in mucosal immunity.</description><subject>Adolescent</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>CD23</subject><subject>Celiac Disease - blood</subject><subject>Celiac Disease - complications</subject><subject>Celiac Disease - pathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>children</subject><subject>CMSE</subject><subject>coeliac disease</subject><subject>Duodenum - immunology</subject><subject>Duodenum - pathology</subject><subject>enteropathy</subject><subject>Enzyme-Linked Immunosorbent Assay - methods</subject><subject>Fas Ligand Protein - blood</subject><subject>FasL</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>IEL</subject><subject>IL‐15</subject><subject>Interleukin-15 - blood</subject><subject>Intestinal Diseases - complications</subject><subject>Intestinal Diseases - immunology</subject><subject>Intestinal Diseases - pathology</subject><subject>Lymphocyte Count</subject><subject>Lymphocytes - metabolism</subject><subject>Lymphocytes - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>milk allergy</subject><subject>Milk Hypersensitivity - blood</subject><subject>Milk Hypersensitivity - complications</subject><subject>Milk Hypersensitivity - immunology</subject><subject>Milk Proteins - immunology</subject><subject>Milk Proteins - metabolism</subject><subject>Other diseases. Semiology</subject><subject>Receptors, IgE - blood</subject><subject>serum</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM9u00AQh1cIREPhDRDyBfVSl_3v9YEDpE0pSiES5bxab8bK0o0ddmyi3PoISH3DPkndJIDEBU4jzXy_mdFHyEtGTxgtizeXs_MTWlEmQDDDReGZVI_IiCmhc2koe0xGlBdFzhnTB-QZ4jdKaSEVfUoOOCulNkKNSPsFUr_MXDPPrgJiD9n4lIvj7GJ6d_OTqePtZOJwmoUmG7frIxz6lyFeZ7PUdhCau5tbhAZDF35AdtZ0kNqV6xabbXCbgRicz04DgkN4Tp7ULiK82NdD8nVydjX-kE8_n1-M301zL41SuRGcq0JxLbWry1KBU6KqSukrwaUUQKmvDZdGz1WlnC6MU95UpqxYoagQTBySo93eVWq_94CdXQb0EKNroO3RltKYUmnKB1LuSJ9axAS1XaWwdGljGbUPpu1g2v5teoi92h_oqyXMf4d-qR2A13vAoXexTq7xAf9wSitZyof7Zset2zjYw-vYryHZBbjYLf71w9t9NETY_Nff9uPsk3g_oZoOnXtLNaqr</recordid><startdate>201204</startdate><enddate>201204</enddate><creator>Kokkonen, Tuomo S.</creator><creator>Augustin, Merja T.</creator><creator>Kokkonen, Jorma</creator><creator>Karttunen, Riitta</creator><creator>Karttunen, Tuomo J.</creator><general>Copyright by ESPGHAN and NASPGHAN</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201204</creationdate><title>Serum and Tissue CD23, IL‐15, and FasL in Cow's‐Milk Protein–sensitive Enteropathy and in Coeliac Disease</title><author>Kokkonen, Tuomo S. ; Augustin, Merja T. ; Kokkonen, Jorma ; Karttunen, Riitta ; Karttunen, Tuomo J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4855-83225752646af995ea53bb94cb32443e00cf82486d5b5a678a5c8b89b17503313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>CD23</topic><topic>Celiac Disease - blood</topic><topic>Celiac Disease - complications</topic><topic>Celiac Disease - pathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>children</topic><topic>CMSE</topic><topic>coeliac disease</topic><topic>Duodenum - immunology</topic><topic>Duodenum - pathology</topic><topic>enteropathy</topic><topic>Enzyme-Linked Immunosorbent Assay - methods</topic><topic>Fas Ligand Protein - blood</topic><topic>FasL</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>IEL</topic><topic>IL‐15</topic><topic>Interleukin-15 - blood</topic><topic>Intestinal Diseases - complications</topic><topic>Intestinal Diseases - immunology</topic><topic>Intestinal Diseases - pathology</topic><topic>Lymphocyte Count</topic><topic>Lymphocytes - metabolism</topic><topic>Lymphocytes - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>milk allergy</topic><topic>Milk Hypersensitivity - blood</topic><topic>Milk Hypersensitivity - complications</topic><topic>Milk Hypersensitivity - immunology</topic><topic>Milk Proteins - immunology</topic><topic>Milk Proteins - metabolism</topic><topic>Other diseases. Semiology</topic><topic>Receptors, IgE - blood</topic><topic>serum</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kokkonen, Tuomo S.</creatorcontrib><creatorcontrib>Augustin, Merja T.</creatorcontrib><creatorcontrib>Kokkonen, Jorma</creatorcontrib><creatorcontrib>Karttunen, Riitta</creatorcontrib><creatorcontrib>Karttunen, Tuomo J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kokkonen, Tuomo S.</au><au>Augustin, Merja T.</au><au>Kokkonen, Jorma</au><au>Karttunen, Riitta</au><au>Karttunen, Tuomo J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum and Tissue CD23, IL‐15, and FasL in Cow's‐Milk Protein–sensitive Enteropathy and in Coeliac Disease</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>2012-04</date><risdate>2012</risdate><volume>54</volume><issue>4</issue><spage>525</spage><epage>531</epage><pages>525-531</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>ABSTRACT
Objectives:
The aim of the study was to explore pathogenesis and find new serum markers for cow's‐milk–sensitive enteropathy (CMSE) and coeliac disease (CD). We assessed the intestinal expression and serum concentration of CD23, IL‐15, and FasL. We hypothesised that the serum levels of CD23, a protein expressed in the lymphoid follicles, would be associated with lymphonodular hyperplasia (LNH), a feature characteristic of CMSE. We also presumed that interleukin (IL)‐15 and FasL, functionally connected with proliferation and apoptosis of the intraepithelial lymphocytes (IELs), would relate with the increased numbers of IELs present in both CMSE and CD.
Methods:
Twenty‐three children with CMSE, 20 with untreated CD, and 14 controls were studied for CD3, α/β‐ and γ/δ‐expressing IELs, and for duodenal and ileal expression of CD23, FasL, and IL‐15 by immunohistochemistry, and for serum concentration of sCD23, sFasL, and sIL‐15 by enzyme‐linked immunosorbent assay.
Results:
There was a trend for increase in sCD23 serum levels in untreated CMSE and in CD (P = 0.074; P = 0.077). CD23 was expressed in the mucosal germinal centres, but sCD23 was not related to presence of LNH. In CMSE, there was a trend for increase in serum sFasL (P = 0.07) and high levels associated with LNH (P = 0.025) and correlated with the IEL numbers (P < 0.05). Mucosal high endothelial venules adjacent to lymphoid follicles showed an intensive FasL expression.
Conclusions:
Serum sCD23 shows a trend of increment in CMSE and CD, and in the latter, sCD23 level may provide information about the severity of villous atrophy. In CMSE, high serum sFasL indicates both LNH and an increase of IELs, suggesting importance of FasL‐mediated mechanisms in the pathogenesis of these features characteristic of CMSE. Further studies are necessary to evaluate whether intensive FasL expression in mucosal high endothelial venules presents a regulatory element in mucosal immunity.</abstract><cop>Hagerstown, MD</cop><pub>Copyright by ESPGHAN and NASPGHAN</pub><pmid>21946835</pmid><doi>10.1097/MPG.0b013e318237c145</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of pediatric gastroenterology and nutrition, 2012-04, Vol.54 (4), p.525-531 |
| issn | 0277-2116 1536-4801 |
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| subjects | Adolescent Apoptosis Biological and medical sciences Biomarkers - blood Case-Control Studies CD23 Celiac Disease - blood Celiac Disease - complications Celiac Disease - pathology Child Child, Preschool children CMSE coeliac disease Duodenum - immunology Duodenum - pathology enteropathy Enzyme-Linked Immunosorbent Assay - methods Fas Ligand Protein - blood FasL Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Humans IEL IL‐15 Interleukin-15 - blood Intestinal Diseases - complications Intestinal Diseases - immunology Intestinal Diseases - pathology Lymphocyte Count Lymphocytes - metabolism Lymphocytes - pathology Male Medical sciences milk allergy Milk Hypersensitivity - blood Milk Hypersensitivity - complications Milk Hypersensitivity - immunology Milk Proteins - immunology Milk Proteins - metabolism Other diseases. Semiology Receptors, IgE - blood serum Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Serum and Tissue CD23, IL‐15, and FasL in Cow's‐Milk Protein–sensitive Enteropathy and in Coeliac Disease |
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