Successful treatment of a rare metastatic malignant carotid body tumour in a young adult, with conservative surgery and local radiotherapy
We report a patient with a malignant carotid body paraganglioma treated with surgery and adjuvant radiotherapy. We discuss her treatment and outcome in the light of the published literature. A 26-year-old woman presented with a 12-month history of a painless, left-sided neck lump. Ultrasound, comput...
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| Veröffentlicht in: | Journal of laryngology and otology 2012-04, Vol.126 (4), p.428-431 |
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| description | We report a patient with a malignant carotid body paraganglioma treated with surgery and adjuvant radiotherapy. We discuss her treatment and outcome in the light of the published literature.
A 26-year-old woman presented with a 12-month history of a painless, left-sided neck lump. Ultrasound, computed tomography and magnetic resonance imaging revealed a carotid body tumour, which at surgical excision was found to be adherent to the vagus and hypoglossal cranial nerves (X and XII). The tumour was resected from the surrounding structures. Two local lymph nodes were removed to allow access. The internal carotid artery was also involved and had to be repaired with a synthetic graft. Histology and immunohistochemistry confirmed malignant carotid body paraganglioma. There were positive resection margins, and cervical lymph node metastasis was reported in one of the two nodes. Post-operatively, she had left Horner's syndrome, left vocal fold palsy and right upper limb weakness, all of which resolved spontaneously. She underwent adjuvant radiotherapy and remained recurrence free after 30 months.
Malignant carotid body paraganglioma can affect young adults, with an insidious onset of symptoms. In this patient, local excision (without neck dissection) and adjuvant radiotherapy were well tolerated and resulted in satisfactory local disease control. |
| doi_str_mv | 10.1017/S0022215111002994 |
| format | Article |
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A 26-year-old woman presented with a 12-month history of a painless, left-sided neck lump. Ultrasound, computed tomography and magnetic resonance imaging revealed a carotid body tumour, which at surgical excision was found to be adherent to the vagus and hypoglossal cranial nerves (X and XII). The tumour was resected from the surrounding structures. Two local lymph nodes were removed to allow access. The internal carotid artery was also involved and had to be repaired with a synthetic graft. Histology and immunohistochemistry confirmed malignant carotid body paraganglioma. There were positive resection margins, and cervical lymph node metastasis was reported in one of the two nodes. Post-operatively, she had left Horner's syndrome, left vocal fold palsy and right upper limb weakness, all of which resolved spontaneously. She underwent adjuvant radiotherapy and remained recurrence free after 30 months.
Malignant carotid body paraganglioma can affect young adults, with an insidious onset of symptoms. In this patient, local excision (without neck dissection) and adjuvant radiotherapy were well tolerated and resulted in satisfactory local disease control.</description><identifier>ISSN: 0022-2151</identifier><identifier>EISSN: 1748-5460</identifier><identifier>DOI: 10.1017/S0022215111002994</identifier><identifier>PMID: 22032730</identifier><identifier>CODEN: JLOTAX</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Biological and medical sciences ; Carotid arteries ; Carotid Arteries - pathology ; Carotid Arteries - surgery ; Carotid Body Tumor - diagnosis ; Carotid Body Tumor - pathology ; Carotid Body Tumor - radiotherapy ; Carotid Body Tumor - surgery ; Female ; Histology ; Horner Syndrome - etiology ; Hospitals ; Humans ; Hypoglossal Nerve - pathology ; Hypoglossal Nerve - surgery ; Lymphatic Metastasis ; Lymphatic system ; Magnetic Resonance Imaging ; Medical sciences ; Metastasis ; Multidisciplinary teams ; Muscle Weakness - etiology ; Neck ; Neoplasm Staging ; Neurology ; Otorhinolaryngology. Stomatology ; Patients ; Postoperative Complications ; Radiation therapy ; Radiotherapy, Adjuvant ; Stains & staining ; Surgery ; Tomography ; Tumors ; Tumors of the nervous system. Phacomatoses ; Upper Extremity - physiopathology ; Vagus Nerve Diseases - etiology ; Vagus Nerve Diseases - pathology ; Vascular Surgical Procedures - methods ; Veins & arteries</subject><ispartof>Journal of laryngology and otology, 2012-04, Vol.126 (4), p.428-431</ispartof><rights>Copyright © JLO (1984) Limited 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-1144961876e7fe3455b5ff81012bf74ec2cabfce21d4cec19b8dd342607dc8c03</citedby><cites>FETCH-LOGICAL-c435t-1144961876e7fe3455b5ff81012bf74ec2cabfce21d4cec19b8dd342607dc8c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0022215111002994/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25773078$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22032730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williamson, J</creatorcontrib><creatorcontrib>Leopold, G</creatorcontrib><creatorcontrib>Prabhu, V</creatorcontrib><creatorcontrib>Ingrams, D</creatorcontrib><title>Successful treatment of a rare metastatic malignant carotid body tumour in a young adult, with conservative surgery and local radiotherapy</title><title>Journal of laryngology and otology</title><addtitle>J Laryngol Otol</addtitle><description>We report a patient with a malignant carotid body paraganglioma treated with surgery and adjuvant radiotherapy. We discuss her treatment and outcome in the light of the published literature.
A 26-year-old woman presented with a 12-month history of a painless, left-sided neck lump. Ultrasound, computed tomography and magnetic resonance imaging revealed a carotid body tumour, which at surgical excision was found to be adherent to the vagus and hypoglossal cranial nerves (X and XII). The tumour was resected from the surrounding structures. Two local lymph nodes were removed to allow access. The internal carotid artery was also involved and had to be repaired with a synthetic graft. Histology and immunohistochemistry confirmed malignant carotid body paraganglioma. There were positive resection margins, and cervical lymph node metastasis was reported in one of the two nodes. Post-operatively, she had left Horner's syndrome, left vocal fold palsy and right upper limb weakness, all of which resolved spontaneously. She underwent adjuvant radiotherapy and remained recurrence free after 30 months.
Malignant carotid body paraganglioma can affect young adults, with an insidious onset of symptoms. In this patient, local excision (without neck dissection) and adjuvant radiotherapy were well tolerated and resulted in satisfactory local disease control.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Carotid arteries</subject><subject>Carotid Arteries - pathology</subject><subject>Carotid Arteries - surgery</subject><subject>Carotid Body Tumor - diagnosis</subject><subject>Carotid Body Tumor - pathology</subject><subject>Carotid Body Tumor - radiotherapy</subject><subject>Carotid Body Tumor - surgery</subject><subject>Female</subject><subject>Histology</subject><subject>Horner Syndrome - etiology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypoglossal Nerve - pathology</subject><subject>Hypoglossal Nerve - surgery</subject><subject>Lymphatic Metastasis</subject><subject>Lymphatic system</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Metastasis</subject><subject>Multidisciplinary teams</subject><subject>Muscle Weakness - etiology</subject><subject>Neck</subject><subject>Neoplasm Staging</subject><subject>Neurology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Patients</subject><subject>Postoperative Complications</subject><subject>Radiation therapy</subject><subject>Radiotherapy, Adjuvant</subject><subject>Stains & staining</subject><subject>Surgery</subject><subject>Tomography</subject><subject>Tumors</subject><subject>Tumors of the nervous system. Phacomatoses</subject><subject>Upper Extremity - physiopathology</subject><subject>Vagus Nerve Diseases - etiology</subject><subject>Vagus Nerve Diseases - pathology</subject><subject>Vascular Surgical Procedures - methods</subject><subject>Veins & arteries</subject><issn>0022-2151</issn><issn>1748-5460</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUuLFDEUhYMoTjv6A9xIQEQXtiapVCW1HAZfMOBidF3cSm56MlRV2jxG6i_4q00z7QNFVwnc75ybnEPIY85eccbV60vGhBC85ZzXW9_LO2TDldTbVnbsLtkcxtvD_IQ8SOmasSpi4j45EYI1QjVsQ75dFmMwJVcmmiNCnnHJNDgKNEJEOmOGlCF7Q2eY_G6BOjYQQ_aWjsGuNJc5lEj9UiVrKMuOgi1Tfkm_-nxFTVgSxptqcIM0lbjDuFJYLJ2CganusD7kK4ywXx-Sew6mhI-O5yn5_PbNp_P324uP7z6cn11sjWzavOVcyr7jWnWoHDaybcfWOV0DEaNTEo0wMDqDgltp0PB-1NY2UnRMWaMNa07J81vffQxfCqY8zD4ZnCZYMJQ09FLrnjWsreSL_5KcK6573bCuok__QK9rKkv9x8CZUFoz3stK8VvKxJBSRDfso58hrhUaDpUOf1VaNU-OzmWc0f5U_OiwAs-OAKSaqYuwGJ9-ca2qlNKVa47LYR6jtzv8_Y3_Wv8dKSO5Ow</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Williamson, J</creator><creator>Leopold, G</creator><creator>Prabhu, V</creator><creator>Ingrams, D</creator><general>Cambridge University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>20120401</creationdate><title>Successful treatment of a rare metastatic malignant carotid body tumour in a young adult, with conservative surgery and local radiotherapy</title><author>Williamson, J ; Leopold, G ; Prabhu, V ; Ingrams, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-1144961876e7fe3455b5ff81012bf74ec2cabfce21d4cec19b8dd342607dc8c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Carotid arteries</topic><topic>Carotid Arteries - pathology</topic><topic>Carotid Arteries - surgery</topic><topic>Carotid Body Tumor - diagnosis</topic><topic>Carotid Body Tumor - pathology</topic><topic>Carotid Body Tumor - radiotherapy</topic><topic>Carotid Body Tumor - surgery</topic><topic>Female</topic><topic>Histology</topic><topic>Horner Syndrome - etiology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypoglossal Nerve - pathology</topic><topic>Hypoglossal Nerve - surgery</topic><topic>Lymphatic Metastasis</topic><topic>Lymphatic system</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Metastasis</topic><topic>Multidisciplinary teams</topic><topic>Muscle Weakness - etiology</topic><topic>Neck</topic><topic>Neoplasm Staging</topic><topic>Neurology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Patients</topic><topic>Postoperative Complications</topic><topic>Radiation therapy</topic><topic>Radiotherapy, Adjuvant</topic><topic>Stains & staining</topic><topic>Surgery</topic><topic>Tomography</topic><topic>Tumors</topic><topic>Tumors of the nervous system. Phacomatoses</topic><topic>Upper Extremity - physiopathology</topic><topic>Vagus Nerve Diseases - etiology</topic><topic>Vagus Nerve Diseases - pathology</topic><topic>Vascular Surgical Procedures - methods</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williamson, J</creatorcontrib><creatorcontrib>Leopold, G</creatorcontrib><creatorcontrib>Prabhu, V</creatorcontrib><creatorcontrib>Ingrams, D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of laryngology and otology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williamson, J</au><au>Leopold, G</au><au>Prabhu, V</au><au>Ingrams, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful treatment of a rare metastatic malignant carotid body tumour in a young adult, with conservative surgery and local radiotherapy</atitle><jtitle>Journal of laryngology and otology</jtitle><addtitle>J Laryngol Otol</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>126</volume><issue>4</issue><spage>428</spage><epage>431</epage><pages>428-431</pages><issn>0022-2151</issn><eissn>1748-5460</eissn><coden>JLOTAX</coden><abstract>We report a patient with a malignant carotid body paraganglioma treated with surgery and adjuvant radiotherapy. We discuss her treatment and outcome in the light of the published literature.
A 26-year-old woman presented with a 12-month history of a painless, left-sided neck lump. Ultrasound, computed tomography and magnetic resonance imaging revealed a carotid body tumour, which at surgical excision was found to be adherent to the vagus and hypoglossal cranial nerves (X and XII). The tumour was resected from the surrounding structures. Two local lymph nodes were removed to allow access. The internal carotid artery was also involved and had to be repaired with a synthetic graft. Histology and immunohistochemistry confirmed malignant carotid body paraganglioma. There were positive resection margins, and cervical lymph node metastasis was reported in one of the two nodes. Post-operatively, she had left Horner's syndrome, left vocal fold palsy and right upper limb weakness, all of which resolved spontaneously. She underwent adjuvant radiotherapy and remained recurrence free after 30 months.
Malignant carotid body paraganglioma can affect young adults, with an insidious onset of symptoms. In this patient, local excision (without neck dissection) and adjuvant radiotherapy were well tolerated and resulted in satisfactory local disease control.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>22032730</pmid><doi>10.1017/S0022215111002994</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Carotid arteries Carotid Arteries - pathology Carotid Arteries - surgery Carotid Body Tumor - diagnosis Carotid Body Tumor - pathology Carotid Body Tumor - radiotherapy Carotid Body Tumor - surgery Female Histology Horner Syndrome - etiology Hospitals Humans Hypoglossal Nerve - pathology Hypoglossal Nerve - surgery Lymphatic Metastasis Lymphatic system Magnetic Resonance Imaging Medical sciences Metastasis Multidisciplinary teams Muscle Weakness - etiology Neck Neoplasm Staging Neurology Otorhinolaryngology. Stomatology Patients Postoperative Complications Radiation therapy Radiotherapy, Adjuvant Stains & staining Surgery Tomography Tumors Tumors of the nervous system. Phacomatoses Upper Extremity - physiopathology Vagus Nerve Diseases - etiology Vagus Nerve Diseases - pathology Vascular Surgical Procedures - methods Veins & arteries |
| title | Successful treatment of a rare metastatic malignant carotid body tumour in a young adult, with conservative surgery and local radiotherapy |
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