Anti-inflammatory mechanism of PPARγ on LPS-induced pulp cells: Role of the ROS removal activity

Abstract Objectives PPARγ has an anti-inflammatory effect on LPS-induced pulpal inflammation by decreasing the expression of MMPs, ICAM-1 and VCAM-1. However, the anti-inflammatory mechanism of PPARγ on the cell adhesion molecules and their upper signal pathways has not been clarified in pulp cells....

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Veröffentlicht in:	Archives of oral biology 2012-04, Vol.57 (4), p.392-400
Hauptverfasser:	Kim, Jae-Cheol, Lee, Young-Hee, Yu, Mi-Kyung, Lee, Nan-Hee, Park, Jong-Duk, Bhattarai, Govinda, Yi, Ho-Keun
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Analysis of Variance Anti-Inflammatory Agents - pharmacology Cell Adhesion Molecules - metabolism Cells, Cultured Dental Pulp - cytology Dental Pulp - drug effects Dental Pulp - metabolism Dentistry ERK1/2 Humans Hypoglycemic Agents - pharmacology ICAM-1 Lipopolysaccharides - pharmacology Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - metabolism NF-kappa B - metabolism NF-κB PPAR gamma - physiology PPARγ Pulpal inflammation Reactive Oxygen Species - antagonists & inhibitors ROS Thiazolidinediones - pharmacology VCAM-1
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