Effects of Afobazole on Cognitive Behavior of the Offspring of Rats Exposed to Tobacco Smoke during Gestation Period
Experiments on the model of foraging behavior formation under conditions of free choice (T-maze) revealed learning failure against the background of reduced motor activity in the offspring of rats exposed to tobacco smoke on gestation days 1–20. Afobazole administered to pregnant rats orally in dose...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2011-05, Vol.151 (1), p.41-46 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Shreder, O. V. Solomina, A. S. Tsorin, I. B. Trofimov, S. S. Durnev, A. D. Seredenin, S. B. |
| description | Experiments on the model of foraging behavior formation under conditions of free choice (T-maze) revealed learning failure against the background of reduced motor activity in the offspring of rats exposed to tobacco smoke on gestation days 1–20. Afobazole administered to pregnant rats orally in doses of 1 or 10 mg/kg daily during the whole gestation and/or entering rat pup body with breast milk from mothers receiving 200 mg/kg to day 20 of their life normalized their learning capacity. The formation of short-term and long-term memory in animals receiving afobazole did not differ from the control. Hence, afobazole corrects cognitive disorders in rats exposed to tobacco smoke during prenatal development. |
| doi_str_mv | 10.1007/s10517-011-1255-6 |
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| subjects | Administration, Oral Animals Animals, Newborn Anti-Anxiety Agents - administration & dosage Behavior, Animal - drug effects Benzimidazoles - administration & dosage Biomedical and Life Sciences Biomedicine Cell Biology Cognition - drug effects Dose-Response Relationship, Drug Female Fetus Growth Humans Internal Medicine Laboratory Medicine Male Maze Learning - drug effects Memory, Long-Term - drug effects Memory, Short-Term - drug effects Morpholines - administration & dosage Motor Activity - drug effects Pathology Pharmacology and Toxicology Pregnancy Prenatal Exposure Delayed Effects - physiopathology Prenatal Exposure Delayed Effects - prevention & control Rats Smoke - adverse effects Smoking |
| title | Effects of Afobazole on Cognitive Behavior of the Offspring of Rats Exposed to Tobacco Smoke during Gestation Period |
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