Investigation of the electrophilic reactivity of the cytotoxic marine alkaloid discorhabdin B

The mechanisms of action of the cytotoxic marine pyrroloiminoquinone alkaloids the discorhabdins are unknown. We have determined that discorhabdin B acts as an electrophile towards biomimetic thiol nucleophiles leading to debrominated adducts. In contrast, less potent cytotoxins discorhabdins D and...

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Veröffentlicht in:	Organic & biomolecular chemistry 2012-04, Vol.10 (15), p.3092-3097
Hauptverfasser:	Lam, Cary F C, Grkovic, Tanja, Pearce, A Norrie, Copp, Brent R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Aquatic Organisms Molecular Structure Porifera Quinolones - chemistry Quinolones - isolation & purification Stereoisomerism Structure-Activity Relationship Thiazepines - chemistry Thiazepines - isolation & purification
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