High levels of nuclear MYC protein predict the presence of MYC rearrangement in diffuse large B-cell lymphoma

Determining the presence of MYC gene rearrangements is becoming an increasingly important part of the diagnostic workup in aggressive lymphoma. Cytogenetic MYC alterations aid in differentiating diffuse large B-cell lymphoma (DLBCL) from Burkitt lymphoma. In addition, MYC aberrations are associated...

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Veröffentlicht in:	The American journal of surgical pathology 2012-04, Vol.36 (4), p.612-619
Hauptverfasser:	Green, Tina Marie, Nielsen, Ole, de Stricker, Karin, Xu-Monette, Zijun Y, Young, Ken H, Møller, Michael Boe
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Burkitt Lymphoma - diagnosis Cell Nucleus - metabolism Cell Nucleus - pathology DNA, Neoplasm - analysis Gene Rearrangement Genes, myc Humans Immunohistochemistry - methods In Situ Hybridization, Fluorescence Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - metabolism Lymphoma, Large B-Cell, Diffuse - pathology Predictive Value of Tests Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Real-Time Polymerase Chain Reaction ROC Curve Tissue Array Analysis
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