Tributyltin Alters Osteocalcin, Matrix Metalloproteinase 20 and Dentin Sialophosphoprotein Gene Expression in Mineralizing Mouse Embryonic Tooth in vitro

We showed in a previous in vitro study that tributyltin (TBT) arrests dentin mineralization and enamel formation in developing mouse tooth. The present aim was to investigate the effect of TBT on the expression of genes associated with mineralization of dental hard tissues. Embryonic day 18 mouse ma...

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Veröffentlicht in:	Cells, tissues, organs tissues, organs, 2012-03, Vol.195 (4), p.287-295
Hauptverfasser:	Salmela, Eija, Alaluusua, Satu, Sahlberg, Carin, Lukinmaa, Pirjo-Liisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline phosphatase Ameloblasts Animals Calcification, Physiologic - drug effects Calcification, Physiologic - genetics Dental enamel Dentin Differentiation Dmp1 protein Dspp protein Embryos Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Gene expression Gene Expression Regulation - drug effects Mandible Matrix metalloproteinase Matrix Metalloproteinase 20 - genetics Matrix Metalloproteinase 20 - metabolism Mice Mineralization Molars Odontoblasts Original Paper Osteocalcin Osteocalcin - genetics Osteocalcin - metabolism Phosphoproteins - genetics Phosphoproteins - metabolism Polymerase chain reaction RNA, Messenger - genetics RNA, Messenger - metabolism Sialoglycoproteins - genetics Sialoglycoproteins - metabolism Teeth Tooth - drug effects Tooth - embryology Tooth - metabolism Trialkyltin Compounds - pharmacology Tributyltin
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