Chronic hypobaric hypoxia mediated skeletal muscle atrophy: role of ubiquitin–proteasome pathway and calpains

The most frequently reported symptom of exposure to high altitude is loss of body mass and decreased performance which has been attributed to altered protein metabolism affecting skeletal muscles mass. The present study explores the mechanism of chronic hypobaric hypoxia mediated skeletal muscle was...

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Veröffentlicht in:	Molecular and cellular biochemistry 2012-05, Vol.364 (1-2), p.101-113
Hauptverfasser:	Chaudhary, Pooja, Suryakumar, Geetha, Prasad, Rajendra, Singh, Som Nath, Ali, Shakir, Ilavazhagan, Govindsamy
Format:	Artikel
Sprache:	eng
Schlagworte:	Altitude Amino acids Animals Atrophy - physiopathology Biochemistry Biodegradation Biomedical and Life Sciences Calpain - metabolism Carbon Radioisotopes Cardiology Cellular biology Enzymatic activity Enzymes Hypoxia Hypoxia - physiopathology Life Sciences Male Medical Biochemistry Motor Activity Muscle, Skeletal - metabolism Muscle, Skeletal - physiopathology Muscles Musculoskeletal system Myofibrils - metabolism Oncology Physiological aspects Pressure - adverse effects Proteasome Endopeptidase Complex - metabolism Protein biosynthesis Protein synthesis Proteins - metabolism Proteolysis Rats Rats, Sprague-Dawley Ubiquitin Ubiquitin - metabolism
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