Quality-Adjusted Life Expectancies in Patients with Rheumatoid Arthritis—Comparison of Index Scores from EQ-5D, 15D, and SF-6D

Abstract Background The aim of this study was to compare quality-adjusted life expectancy (QALE) for patients with rheumatoid arthritis generated from three generic health-related quality-of-life instruments. Methods Patients from 11 Danish rheumatology outpatient clinics were asked to report curren...

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Veröffentlicht in:Value in health 2012-03, Vol.15 (2), p.334-339
Hauptverfasser: Sørensen, Jan, MSc, Linde, Louise, MD, PhD, Østergaard, Mikkel, MD, PhD, DMSc, Hetland, Merete Lund, MD, PhD, DMSc
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container_start_page 334
container_title Value in health
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creator Sørensen, Jan, MSc
Linde, Louise, MD, PhD
Østergaard, Mikkel, MD, PhD, DMSc
Hetland, Merete Lund, MD, PhD, DMSc
description Abstract Background The aim of this study was to compare quality-adjusted life expectancy (QALE) for patients with rheumatoid arthritis generated from three generic health-related quality-of-life instruments. Methods Patients from 11 Danish rheumatology outpatient clinics were asked to report current health status using the EuroQol five-dimensional questionnaire (EQ-5D), 15D, and six-dimensional health state short form (derived from SF-12) (SF-6D) instruments. Clinical staff provided data on current disease status (C-reactive protein and Disease Activity Score that involves clinical assessment of 28 joints). National mortality data were retrieved from Statistics Denmark. For each of the three instruments, mean index scores were estimated by gender and 5-year age groups. Partial QALE was estimated for the age interval 30 to 79 years for different subsamples. Results Although the three quality-of-life index scores were highly correlated, there were statistically significant differences between the average index scores from the three instruments. The 15D provided the highest index score and SF-6D the lowest score. For a 30-year-old patient, the partial QALE ranged from 37.9 quality-adjusted life-years using the SF-6D to 45.6 quality-adjusted life-years using the 15D. The QALE for men and women differed by 6.2%, 4.0%, and 5.3% when the calculation was based on EQ-5D, SF-6D, and 15D index scores, respectively. The largest differences were observed when patients were grouped by functional status (Health Assessment Questionnaire score), where the EQ-5D showed a 50% difference in index score between the best and worst functional group while the SF-6D and 15D showed smaller differences (32% and 14%, respectively). Discussion This analysis has shown the difference in QALE estimates related to different instruments. The study emphasizes that unless outcome studies use the same instruments and scoring algorithms, the results will not be directly comparable.
doi_str_mv 10.1016/j.jval.2011.09.010
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Methods Patients from 11 Danish rheumatology outpatient clinics were asked to report current health status using the EuroQol five-dimensional questionnaire (EQ-5D), 15D, and six-dimensional health state short form (derived from SF-12) (SF-6D) instruments. Clinical staff provided data on current disease status (C-reactive protein and Disease Activity Score that involves clinical assessment of 28 joints). National mortality data were retrieved from Statistics Denmark. For each of the three instruments, mean index scores were estimated by gender and 5-year age groups. Partial QALE was estimated for the age interval 30 to 79 years for different subsamples. Results Although the three quality-of-life index scores were highly correlated, there were statistically significant differences between the average index scores from the three instruments. The 15D provided the highest index score and SF-6D the lowest score. For a 30-year-old patient, the partial QALE ranged from 37.9 quality-adjusted life-years using the SF-6D to 45.6 quality-adjusted life-years using the 15D. The QALE for men and women differed by 6.2%, 4.0%, and 5.3% when the calculation was based on EQ-5D, SF-6D, and 15D index scores, respectively. The largest differences were observed when patients were grouped by functional status (Health Assessment Questionnaire score), where the EQ-5D showed a 50% difference in index score between the best and worst functional group while the SF-6D and 15D showed smaller differences (32% and 14%, respectively). Discussion This analysis has shown the difference in QALE estimates related to different instruments. The study emphasizes that unless outcome studies use the same instruments and scoring algorithms, the results will not be directly comparable.</description><identifier>ISSN: 1098-3015</identifier><identifier>EISSN: 1524-4733</identifier><identifier>DOI: 10.1016/j.jval.2011.09.010</identifier><identifier>PMID: 22433765</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>15D ; Adult ; Aged ; Ambulatory Care ; Arthritis, Rheumatoid - physiopathology ; Arthritis, Rheumatoid - psychology ; C-reactive protein ; Cross-Sectional Studies ; Denmark - epidemiology ; EQ-5D ; Female ; Health Status ; Humans ; Internal Medicine ; Life Expectancy ; Male ; Middle Aged ; Mortality ; Quality of life ; quality-adjusted life expectancies ; Quality-Adjusted Life Years ; rheumatoid arthritis ; SF-6D ; Short forms ; Surveys and Questionnaires - standards</subject><ispartof>Value in health, 2012-03, Vol.15 (2), p.334-339</ispartof><rights>International Society for Pharmacoeconomics and Outcomes Research (ISPOR)</rights><rights>2012 International Society for Pharmacoeconomics and Outcomes Research (ISPOR)</rights><rights>Copyright © 2012 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). 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Methods Patients from 11 Danish rheumatology outpatient clinics were asked to report current health status using the EuroQol five-dimensional questionnaire (EQ-5D), 15D, and six-dimensional health state short form (derived from SF-12) (SF-6D) instruments. Clinical staff provided data on current disease status (C-reactive protein and Disease Activity Score that involves clinical assessment of 28 joints). National mortality data were retrieved from Statistics Denmark. For each of the three instruments, mean index scores were estimated by gender and 5-year age groups. Partial QALE was estimated for the age interval 30 to 79 years for different subsamples. Results Although the three quality-of-life index scores were highly correlated, there were statistically significant differences between the average index scores from the three instruments. The 15D provided the highest index score and SF-6D the lowest score. For a 30-year-old patient, the partial QALE ranged from 37.9 quality-adjusted life-years using the SF-6D to 45.6 quality-adjusted life-years using the 15D. The QALE for men and women differed by 6.2%, 4.0%, and 5.3% when the calculation was based on EQ-5D, SF-6D, and 15D index scores, respectively. The largest differences were observed when patients were grouped by functional status (Health Assessment Questionnaire score), where the EQ-5D showed a 50% difference in index score between the best and worst functional group while the SF-6D and 15D showed smaller differences (32% and 14%, respectively). Discussion This analysis has shown the difference in QALE estimates related to different instruments. The study emphasizes that unless outcome studies use the same instruments and scoring algorithms, the results will not be directly comparable.</description><subject>15D</subject><subject>Adult</subject><subject>Aged</subject><subject>Ambulatory Care</subject><subject>Arthritis, Rheumatoid - physiopathology</subject><subject>Arthritis, Rheumatoid - psychology</subject><subject>C-reactive protein</subject><subject>Cross-Sectional Studies</subject><subject>Denmark - epidemiology</subject><subject>EQ-5D</subject><subject>Female</subject><subject>Health Status</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Life Expectancy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Quality of life</subject><subject>quality-adjusted life expectancies</subject><subject>Quality-Adjusted Life Years</subject><subject>rheumatoid arthritis</subject><subject>SF-6D</subject><subject>Short forms</subject><subject>Surveys and Questionnaires - standards</subject><issn>1098-3015</issn><issn>1524-4733</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNp9ksFu1DAQhiMEoqXwAhyQb3AgYWwnTiIhpNV2C5VWgrJwtrzOROuQxFvbKd1bH4In5ElwtIUDh148Pnz_f5hvkuQlhYwCFe-6rLtRfcaA0gzqDCg8Sk5pwfI0Lzl_HP9QVykHWpwkz7zvAEBwVjxNThjLOS9FcZrcXU2qN-GQLppu8gEbsjYtktXtHnVQozboiRnJFxUMjsGTnybsyNcdToMK1jRk4cLOmWD877tfSzvslTPejsS25HJs8JZstHWxonV2IKurtDh_S-j8qLEhm4tUnD9PnrSq9_jifp4l3y9W35af0vXnj5fLxTrVeVWGVAiR1zxvONVbLBEUVRVSqhpRlnmpQSlQrEbgrKqrQuRFW8FWbUvEUnHFtvwseX3s3Tt7PaEPcjBeY9-rEe3kZSxnhaBVHsk3D5IUGIe6BFZHlB1R7az3Dlu5d2ZQ7hAhOTuSnZwdydmRhFpGRzH06r5_2g7Y_Iv8lRKB90cA4z5uDDrpo4dRY2NctCIbax7u__BfXPdmNFr1P_CAvrOTG-OmJZWeSZCb-UrmI6ExW3Ba8D_-DrbJ</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Sørensen, Jan, MSc</creator><creator>Linde, Louise, MD, PhD</creator><creator>Østergaard, Mikkel, MD, PhD, DMSc</creator><creator>Hetland, Merete Lund, MD, PhD, DMSc</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Quality-Adjusted Life Expectancies in Patients with Rheumatoid Arthritis—Comparison of Index Scores from EQ-5D, 15D, and SF-6D</title><author>Sørensen, Jan, MSc ; Linde, Louise, MD, PhD ; Østergaard, Mikkel, MD, PhD, DMSc ; Hetland, Merete Lund, MD, PhD, DMSc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-6664934d31cbe7e0a1a8e11ad67747c0aa0a29e0328985645f80bab7ee7a3a2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>15D</topic><topic>Adult</topic><topic>Aged</topic><topic>Ambulatory Care</topic><topic>Arthritis, Rheumatoid - physiopathology</topic><topic>Arthritis, Rheumatoid - psychology</topic><topic>C-reactive protein</topic><topic>Cross-Sectional Studies</topic><topic>Denmark - epidemiology</topic><topic>EQ-5D</topic><topic>Female</topic><topic>Health Status</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Life Expectancy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Quality of life</topic><topic>quality-adjusted life expectancies</topic><topic>Quality-Adjusted Life Years</topic><topic>rheumatoid arthritis</topic><topic>SF-6D</topic><topic>Short forms</topic><topic>Surveys and Questionnaires - standards</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sørensen, Jan, MSc</creatorcontrib><creatorcontrib>Linde, Louise, MD, PhD</creatorcontrib><creatorcontrib>Østergaard, Mikkel, MD, PhD, DMSc</creatorcontrib><creatorcontrib>Hetland, Merete Lund, MD, PhD, DMSc</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index &amp; Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><jtitle>Value in health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sørensen, Jan, MSc</au><au>Linde, Louise, MD, PhD</au><au>Østergaard, Mikkel, MD, PhD, DMSc</au><au>Hetland, Merete Lund, MD, PhD, DMSc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quality-Adjusted Life Expectancies in Patients with Rheumatoid Arthritis—Comparison of Index Scores from EQ-5D, 15D, and SF-6D</atitle><jtitle>Value in health</jtitle><addtitle>Value Health</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>15</volume><issue>2</issue><spage>334</spage><epage>339</epage><pages>334-339</pages><issn>1098-3015</issn><eissn>1524-4733</eissn><abstract>Abstract Background The aim of this study was to compare quality-adjusted life expectancy (QALE) for patients with rheumatoid arthritis generated from three generic health-related quality-of-life instruments. Methods Patients from 11 Danish rheumatology outpatient clinics were asked to report current health status using the EuroQol five-dimensional questionnaire (EQ-5D), 15D, and six-dimensional health state short form (derived from SF-12) (SF-6D) instruments. Clinical staff provided data on current disease status (C-reactive protein and Disease Activity Score that involves clinical assessment of 28 joints). National mortality data were retrieved from Statistics Denmark. For each of the three instruments, mean index scores were estimated by gender and 5-year age groups. Partial QALE was estimated for the age interval 30 to 79 years for different subsamples. Results Although the three quality-of-life index scores were highly correlated, there were statistically significant differences between the average index scores from the three instruments. The 15D provided the highest index score and SF-6D the lowest score. For a 30-year-old patient, the partial QALE ranged from 37.9 quality-adjusted life-years using the SF-6D to 45.6 quality-adjusted life-years using the 15D. The QALE for men and women differed by 6.2%, 4.0%, and 5.3% when the calculation was based on EQ-5D, SF-6D, and 15D index scores, respectively. The largest differences were observed when patients were grouped by functional status (Health Assessment Questionnaire score), where the EQ-5D showed a 50% difference in index score between the best and worst functional group while the SF-6D and 15D showed smaller differences (32% and 14%, respectively). Discussion This analysis has shown the difference in QALE estimates related to different instruments. The study emphasizes that unless outcome studies use the same instruments and scoring algorithms, the results will not be directly comparable.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>22433765</pmid><doi>10.1016/j.jval.2011.09.010</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects 15D
Adult
Aged
Ambulatory Care
Arthritis, Rheumatoid - physiopathology
Arthritis, Rheumatoid - psychology
C-reactive protein
Cross-Sectional Studies
Denmark - epidemiology
EQ-5D
Female
Health Status
Humans
Internal Medicine
Life Expectancy
Male
Middle Aged
Mortality
Quality of life
quality-adjusted life expectancies
Quality-Adjusted Life Years
rheumatoid arthritis
SF-6D
Short forms
Surveys and Questionnaires - standards
title Quality-Adjusted Life Expectancies in Patients with Rheumatoid Arthritis—Comparison of Index Scores from EQ-5D, 15D, and SF-6D
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