The chemoadjuvant potential of grape seed procyanidins on p53-related cell death in oral cancer cells
J Oral Pathol Med (2012) 41: 322–331 Background: To clarify the efficacy of grape seed procyanidin (GSP) on antiproliferative effects related to p53 functional status of oral squamous cell carcinoma (OSCC) for its chemoadjuvant potential. Methods: We used GSP to investigate SCC‐25 cells with wild‐...
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| creator | Lin, Yaoh-Shiang Chen, Su-Feng Liu, Chia-Lin Nieh, Shin |
| description | J Oral Pathol Med (2012) 41: 322–331
Background: To clarify the efficacy of grape seed procyanidin (GSP) on antiproliferative effects related to p53 functional status of oral squamous cell carcinoma (OSCC) for its chemoadjuvant potential.
Methods: We used GSP to investigate SCC‐25 cells with wild‐type p53 gene and OEC‐M1 cells with mutant p53 gene for the assessment of antiproliferative effects including cell viability, cell cycle, apoptosis, migration and invasion potential, and alterations of associated oncoproteins involved in cellular and molecular events.
Results: The findings suggest that GSP on OEC‐M1 cells leads to cell cycle arrest by increasing the expression of p21Cip1/p27Kip1 protein without functioning mitochondria‐mediated apoptosis, whereas GSP on SCC‐25 cells inhibits cell proliferation via both G1‐phase arrest and mitochondria‐mediated apoptosis in a dose‐dependent manner as a result of alterations of Bcl‐2. GSP also inhibits the migration and invasion of both cells, which are associated with the suppression of matrix metalloproteinases (MMPs), MMP‐2 and MMP‐9.
Conclusion: Antiproliferative effectiveness of GSP is closely associated with the p53 status of OSCC cells. GSP displays chemoadjuvant potential via cell cycle blockage and apoptotic induction. Our findings clearly suggest that GSP may play a role as a novel chemopreventive or therapeutic agent for OSCC. |
| doi_str_mv | 10.1111/j.1600-0714.2011.01103.x |
| format | Article |
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Background: To clarify the efficacy of grape seed procyanidin (GSP) on antiproliferative effects related to p53 functional status of oral squamous cell carcinoma (OSCC) for its chemoadjuvant potential.
Methods: We used GSP to investigate SCC‐25 cells with wild‐type p53 gene and OEC‐M1 cells with mutant p53 gene for the assessment of antiproliferative effects including cell viability, cell cycle, apoptosis, migration and invasion potential, and alterations of associated oncoproteins involved in cellular and molecular events.
Results: The findings suggest that GSP on OEC‐M1 cells leads to cell cycle arrest by increasing the expression of p21Cip1/p27Kip1 protein without functioning mitochondria‐mediated apoptosis, whereas GSP on SCC‐25 cells inhibits cell proliferation via both G1‐phase arrest and mitochondria‐mediated apoptosis in a dose‐dependent manner as a result of alterations of Bcl‐2. GSP also inhibits the migration and invasion of both cells, which are associated with the suppression of matrix metalloproteinases (MMPs), MMP‐2 and MMP‐9.
Conclusion: Antiproliferative effectiveness of GSP is closely associated with the p53 status of OSCC cells. GSP displays chemoadjuvant potential via cell cycle blockage and apoptotic induction. Our findings clearly suggest that GSP may play a role as a novel chemopreventive or therapeutic agent for OSCC.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/j.1600-0714.2011.01103.x</identifier><identifier>PMID: 22103929</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Anticarcinogenic Agents - pharmacology ; Antineoplastic Agents - pharmacology ; Apoptosis ; Apoptosis - drug effects ; Bcl-2 protein ; Biological and medical sciences ; Carcinoma, Squamous Cell - pathology ; Cell cycle ; Cell Cycle - drug effects ; Cell Death - drug effects ; Cell Line, Tumor ; Cell migration ; Cell Movement - drug effects ; Cell proliferation ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Cyclin-dependent kinase inhibitor p21 ; Cyclin-Dependent Kinase Inhibitor p21 - drug effects ; Cyclin-dependent kinase inhibitor p27 ; Cyclin-Dependent Kinase Inhibitor p27 - drug effects ; Dentistry ; Dose-Response Relationship, Drug ; G1 Phase - drug effects ; Gelatinase A ; Gelatinase B ; Grape Seed Extract - pharmacology ; grape seed procyanidins ; Humans ; Matrix metalloproteinase ; Matrix Metalloproteinase 2 - drug effects ; Matrix Metalloproteinase 9 - drug effects ; Medical sciences ; Mitochondria ; Mitochondria - drug effects ; Mouth Neoplasms - pathology ; Neoplasm Invasiveness ; Oncogene Proteins - drug effects ; oral squamous cell carcinoma ; Otorhinolaryngology. Stomatology ; p53 ; p53 protein ; Plant Preparations - pharmacology ; Point Mutation - genetics ; Proanthocyanidins - pharmacology ; Protein Kinase Inhibitors - analysis ; Proto-Oncogene Proteins c-bcl-2 - drug effects ; Tumor Suppressor Protein p53 - drug effects ; Tumor Suppressor Protein p53 - genetics ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology ; Vitaceae ; Vitis</subject><ispartof>Journal of oral pathology & medicine, 2012-04, Vol.41 (4), p.322-331</ispartof><rights>2011 John Wiley & Sons A/S</rights><rights>2015 INIST-CNRS</rights><rights>2011 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4693-8fcc232f4469f7fc4a0485374ff91e7c84b5e8d6ed87f26df17718250e3caaac3</citedby><cites>FETCH-LOGICAL-c4693-8fcc232f4469f7fc4a0485374ff91e7c84b5e8d6ed87f26df17718250e3caaac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0714.2011.01103.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0714.2011.01103.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25668563$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22103929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Yaoh-Shiang</creatorcontrib><creatorcontrib>Chen, Su-Feng</creatorcontrib><creatorcontrib>Liu, Chia-Lin</creatorcontrib><creatorcontrib>Nieh, Shin</creatorcontrib><title>The chemoadjuvant potential of grape seed procyanidins on p53-related cell death in oral cancer cells</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>J Oral Pathol Med (2012) 41: 322–331
Background: To clarify the efficacy of grape seed procyanidin (GSP) on antiproliferative effects related to p53 functional status of oral squamous cell carcinoma (OSCC) for its chemoadjuvant potential.
Methods: We used GSP to investigate SCC‐25 cells with wild‐type p53 gene and OEC‐M1 cells with mutant p53 gene for the assessment of antiproliferative effects including cell viability, cell cycle, apoptosis, migration and invasion potential, and alterations of associated oncoproteins involved in cellular and molecular events.
Results: The findings suggest that GSP on OEC‐M1 cells leads to cell cycle arrest by increasing the expression of p21Cip1/p27Kip1 protein without functioning mitochondria‐mediated apoptosis, whereas GSP on SCC‐25 cells inhibits cell proliferation via both G1‐phase arrest and mitochondria‐mediated apoptosis in a dose‐dependent manner as a result of alterations of Bcl‐2. GSP also inhibits the migration and invasion of both cells, which are associated with the suppression of matrix metalloproteinases (MMPs), MMP‐2 and MMP‐9.
Conclusion: Antiproliferative effectiveness of GSP is closely associated with the p53 status of OSCC cells. GSP displays chemoadjuvant potential via cell cycle blockage and apoptotic induction. Our findings clearly suggest that GSP may play a role as a novel chemopreventive or therapeutic agent for OSCC.</description><subject>Anticarcinogenic Agents - pharmacology</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Bcl-2 protein</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell cycle</subject><subject>Cell Cycle - drug effects</subject><subject>Cell Death - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Cell migration</subject><subject>Cell Movement - drug effects</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cyclin-dependent kinase inhibitor p21</subject><subject>Cyclin-Dependent Kinase Inhibitor p21 - drug effects</subject><subject>Cyclin-dependent kinase inhibitor p27</subject><subject>Cyclin-Dependent Kinase Inhibitor p27 - drug effects</subject><subject>Dentistry</subject><subject>Dose-Response Relationship, Drug</subject><subject>G1 Phase - drug effects</subject><subject>Gelatinase A</subject><subject>Gelatinase B</subject><subject>Grape Seed Extract - pharmacology</subject><subject>grape seed procyanidins</subject><subject>Humans</subject><subject>Matrix metalloproteinase</subject><subject>Matrix Metalloproteinase 2 - drug effects</subject><subject>Matrix Metalloproteinase 9 - drug effects</subject><subject>Medical sciences</subject><subject>Mitochondria</subject><subject>Mitochondria - drug effects</subject><subject>Mouth Neoplasms - pathology</subject><subject>Neoplasm Invasiveness</subject><subject>Oncogene Proteins - drug effects</subject><subject>oral squamous cell carcinoma</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>p53</subject><subject>p53 protein</subject><subject>Plant Preparations - pharmacology</subject><subject>Point Mutation - genetics</subject><subject>Proanthocyanidins - pharmacology</subject><subject>Protein Kinase Inhibitors - analysis</subject><subject>Proto-Oncogene Proteins c-bcl-2 - drug effects</subject><subject>Tumor Suppressor Protein p53 - drug effects</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><subject>Vitaceae</subject><subject>Vitis</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV9v0zAUxS0EYt3GV0B-QfCS4P9OHnhAE4xNE4NRtEfLc66pS5pkdsrab4-zlvKGsGTZ1v0d-_hchDAlJc3j7bKkipCCaCpKRigt8yS83DxBs0PhKZqRmoiCScqO0HFKS0Ko5oI-R0eMZbxm9QzBfAHYLWDV22a5_mW7EQ_9CN0YbIt7j39EOwBOAA0eYu-2tgtN6BLuOzxIXkRo7ZhrDtoWN2DHBQ4d7mMWO9s5iI-VdIqeedsmeLFfT9D3jx_mZ5-Kq-vzi7P3V4UTquZF5Z1jnHmRT157JywRleRaeF9T0K4SdxKqRkFTac9U46nWtGKSAHfWWsdP0Ovdvdnr_RrSaFYhTQ5sB_06mfxlSbSoWSbf_JOkhDGpBBN1Rqsd6mKfUgRvhhhWNm4zZKZ2mKWZUjdT6mZqh3lsh9lk6cv9K-u7FTQH4Z_8M_BqD9jkbOtjDi2kv5xUqpKKZ-7djnsILWz_24C5vP4y7bK-2OlDGmFz0Nv40yjNtTS3n88NF2r-7Su5Mbf8N1iwtDo</recordid><startdate>201204</startdate><enddate>201204</enddate><creator>Lin, Yaoh-Shiang</creator><creator>Chen, Su-Feng</creator><creator>Liu, Chia-Lin</creator><creator>Nieh, Shin</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201204</creationdate><title>The chemoadjuvant potential of grape seed procyanidins on p53-related cell death in oral cancer cells</title><author>Lin, Yaoh-Shiang ; Chen, Su-Feng ; Liu, Chia-Lin ; Nieh, Shin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4693-8fcc232f4469f7fc4a0485374ff91e7c84b5e8d6ed87f26df17718250e3caaac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Anticarcinogenic Agents - pharmacology</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Bcl-2 protein</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell cycle</topic><topic>Cell Cycle - drug effects</topic><topic>Cell Death - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Cell migration</topic><topic>Cell Movement - drug effects</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Cyclin-dependent kinase inhibitor p21</topic><topic>Cyclin-Dependent Kinase Inhibitor p21 - drug effects</topic><topic>Cyclin-dependent kinase inhibitor p27</topic><topic>Cyclin-Dependent Kinase Inhibitor p27 - drug effects</topic><topic>Dentistry</topic><topic>Dose-Response Relationship, Drug</topic><topic>G1 Phase - drug effects</topic><topic>Gelatinase A</topic><topic>Gelatinase B</topic><topic>Grape Seed Extract - pharmacology</topic><topic>grape seed procyanidins</topic><topic>Humans</topic><topic>Matrix metalloproteinase</topic><topic>Matrix Metalloproteinase 2 - drug effects</topic><topic>Matrix Metalloproteinase 9 - drug effects</topic><topic>Medical sciences</topic><topic>Mitochondria</topic><topic>Mitochondria - drug effects</topic><topic>Mouth Neoplasms - pathology</topic><topic>Neoplasm Invasiveness</topic><topic>Oncogene Proteins - drug effects</topic><topic>oral squamous cell carcinoma</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>p53</topic><topic>p53 protein</topic><topic>Plant Preparations - pharmacology</topic><topic>Point Mutation - genetics</topic><topic>Proanthocyanidins - pharmacology</topic><topic>Protein Kinase Inhibitors - analysis</topic><topic>Proto-Oncogene Proteins c-bcl-2 - drug effects</topic><topic>Tumor Suppressor Protein p53 - drug effects</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><topic>Vitaceae</topic><topic>Vitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Yaoh-Shiang</creatorcontrib><creatorcontrib>Chen, Su-Feng</creatorcontrib><creatorcontrib>Liu, Chia-Lin</creatorcontrib><creatorcontrib>Nieh, Shin</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Yaoh-Shiang</au><au>Chen, Su-Feng</au><au>Liu, Chia-Lin</au><au>Nieh, Shin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The chemoadjuvant potential of grape seed procyanidins on p53-related cell death in oral cancer cells</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2012-04</date><risdate>2012</risdate><volume>41</volume><issue>4</issue><spage>322</spage><epage>331</epage><pages>322-331</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>J Oral Pathol Med (2012) 41: 322–331
Background: To clarify the efficacy of grape seed procyanidin (GSP) on antiproliferative effects related to p53 functional status of oral squamous cell carcinoma (OSCC) for its chemoadjuvant potential.
Methods: We used GSP to investigate SCC‐25 cells with wild‐type p53 gene and OEC‐M1 cells with mutant p53 gene for the assessment of antiproliferative effects including cell viability, cell cycle, apoptosis, migration and invasion potential, and alterations of associated oncoproteins involved in cellular and molecular events.
Results: The findings suggest that GSP on OEC‐M1 cells leads to cell cycle arrest by increasing the expression of p21Cip1/p27Kip1 protein without functioning mitochondria‐mediated apoptosis, whereas GSP on SCC‐25 cells inhibits cell proliferation via both G1‐phase arrest and mitochondria‐mediated apoptosis in a dose‐dependent manner as a result of alterations of Bcl‐2. GSP also inhibits the migration and invasion of both cells, which are associated with the suppression of matrix metalloproteinases (MMPs), MMP‐2 and MMP‐9.
Conclusion: Antiproliferative effectiveness of GSP is closely associated with the p53 status of OSCC cells. GSP displays chemoadjuvant potential via cell cycle blockage and apoptotic induction. Our findings clearly suggest that GSP may play a role as a novel chemopreventive or therapeutic agent for OSCC.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22103929</pmid><doi>10.1111/j.1600-0714.2011.01103.x</doi><tpages>10</tpages></addata></record> |
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| subjects | Anticarcinogenic Agents - pharmacology Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Bcl-2 protein Biological and medical sciences Carcinoma, Squamous Cell - pathology Cell cycle Cell Cycle - drug effects Cell Death - drug effects Cell Line, Tumor Cell migration Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - drug effects Cyclin-dependent kinase inhibitor p27 Cyclin-Dependent Kinase Inhibitor p27 - drug effects Dentistry Dose-Response Relationship, Drug G1 Phase - drug effects Gelatinase A Gelatinase B Grape Seed Extract - pharmacology grape seed procyanidins Humans Matrix metalloproteinase Matrix Metalloproteinase 2 - drug effects Matrix Metalloproteinase 9 - drug effects Medical sciences Mitochondria Mitochondria - drug effects Mouth Neoplasms - pathology Neoplasm Invasiveness Oncogene Proteins - drug effects oral squamous cell carcinoma Otorhinolaryngology. Stomatology p53 p53 protein Plant Preparations - pharmacology Point Mutation - genetics Proanthocyanidins - pharmacology Protein Kinase Inhibitors - analysis Proto-Oncogene Proteins c-bcl-2 - drug effects Tumor Suppressor Protein p53 - drug effects Tumor Suppressor Protein p53 - genetics Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Vitaceae Vitis |
| title | The chemoadjuvant potential of grape seed procyanidins on p53-related cell death in oral cancer cells |
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