Dose-response assessment of naphthalene-induced genotoxicity and glutathione detoxication in human TK6 lymphoblasts

The dose-response relationship for the induction of micronuclei (MN) and the impact of glutathione (GSH) detoxication on naphthalene-induced cytotoxicity and genotoxicity were investigated in human TK6 cells. TK6 cells were exposed to 10 concentrations ranging from 0.0625 to 30μM naphthalene in the...

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Veröffentlicht in:	Toxicological sciences 2012-04, Vol.126 (2), p.405-412
Hauptverfasser:	Recio, Leslie, Shepard, Kim G, Hernández, Lya G, Kedderis, Gregory L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biotransformation Cell Line Dose-Response Relationship, Drug Glutathione - metabolism Humans Lymphocytes - drug effects Lymphocytes - metabolism Micronucleus Tests Mutagens - toxicity Naphthalenes - toxicity Rats
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