Impact of a Resistant Dextrin on Intestinal Ecology: How Altering the Digestive Ecosystem with NUTRIOSE®, a Soluble Fibre with Prebiotic Properties, May Be Beneficial for Health
OBJECTIVES: The prebiotic potential of NUTRIOSE® – a sugar-free, digestion-resistant dextrin — was evaluated in two randomized, placebo-controlled trials that included 48 and 40 healthy volunteers, respectively. METHODS: In study 1, the effect on colonic bacteria of NUTRIOSE® 10, 15 or 20 g/day admi...
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| Veröffentlicht in: | Journal of international medical research 2012-02, Vol.40 (1), p.211-224 |
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| creator | Lefranc-Millot, C Guérin-Deremaux, L Wils, D Neut, C Miller, LE Saniez-Degrave, MH |
| description | OBJECTIVES: The prebiotic potential of NUTRIOSE® – a sugar-free, digestion-resistant dextrin — was evaluated in two randomized, placebo-controlled trials that included 48 and 40 healthy volunteers, respectively. METHODS: In study 1, the effect on colonic bacteria of NUTRIOSE® 10, 15 or 20 g/day administered for 14 days was examined; in study 2, gut microbial changes in response to NUTRIOSE® 8 g/day for 14 days were monitored using real-time polymerase chain reaction analysis. RESULTS: NUTRIOSE® increased proliferation of Bacteroides and inhibited Clostridum perfringens in both studies, increased β-glucosidase activity (at 10 and 15 g/day) and decreased colonic pH (at 20 g/day). The increase in short-chain fatty acid production with NUTRIOSE® consumption was not statistically significant. There were no indications of gastrointestinal intolerance at any dose. CONCLUSIONS: According to commonly accepted definitions, NUTRIOSE® is a prebiotic soluble fibre that provides a beneficial effect on colonic ecology while preserving digestive comfort. |
| doi_str_mv | 10.1177/147323001204000122 |
| format | Article |
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METHODS: In study 1, the effect on colonic bacteria of NUTRIOSE® 10, 15 or 20 g/day administered for 14 days was examined; in study 2, gut microbial changes in response to NUTRIOSE® 8 g/day for 14 days were monitored using real-time polymerase chain reaction analysis. RESULTS: NUTRIOSE® increased proliferation of Bacteroides and inhibited Clostridum perfringens in both studies, increased β-glucosidase activity (at 10 and 15 g/day) and decreased colonic pH (at 20 g/day). The increase in short-chain fatty acid production with NUTRIOSE® consumption was not statistically significant. There were no indications of gastrointestinal intolerance at any dose. CONCLUSIONS: According to commonly accepted definitions, NUTRIOSE® is a prebiotic soluble fibre that provides a beneficial effect on colonic ecology while preserving digestive comfort.</description><identifier>ISSN: 0300-0605</identifier><identifier>EISSN: 1473-2300</identifier><identifier>DOI: 10.1177/147323001204000122</identifier><identifier>PMID: 22429361</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Administration, Oral ; Adult ; Bacteroides - drug effects ; Bacteroides - growth & development ; Clostridium perfringens - drug effects ; Colony Count, Microbial ; Dextrins - administration & dosage ; Dextrins - pharmacology ; Dietary Fiber ; Feces - microbiology ; Female ; Health ; Humans ; Hydrogen-Ion Concentration - drug effects ; Intestines - drug effects ; Intestines - microbiology ; Male ; Middle Aged ; Prebiotics ; Solubility - drug effects</subject><ispartof>Journal of international medical research, 2012-02, Vol.40 (1), p.211-224</ispartof><rights>2012 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-b0869f6ebfe9d785238cf4ad3807f9e4d9cfde29bcefad4758fb45404f92d9163</citedby><cites>FETCH-LOGICAL-c386t-b0869f6ebfe9d785238cf4ad3807f9e4d9cfde29bcefad4758fb45404f92d9163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/147323001204000122$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/147323001204000122$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,864,21966,27853,27924,27925,44945,45333</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/147323001204000122?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22429361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lefranc-Millot, C</creatorcontrib><creatorcontrib>Guérin-Deremaux, L</creatorcontrib><creatorcontrib>Wils, D</creatorcontrib><creatorcontrib>Neut, C</creatorcontrib><creatorcontrib>Miller, LE</creatorcontrib><creatorcontrib>Saniez-Degrave, MH</creatorcontrib><title>Impact of a Resistant Dextrin on Intestinal Ecology: How Altering the Digestive Ecosystem with NUTRIOSE®, a Soluble Fibre with Prebiotic Properties, May Be Beneficial for Health</title><title>Journal of international medical research</title><addtitle>J Int Med Res</addtitle><description>OBJECTIVES: The prebiotic potential of NUTRIOSE® – a sugar-free, digestion-resistant dextrin — was evaluated in two randomized, placebo-controlled trials that included 48 and 40 healthy volunteers, respectively. METHODS: In study 1, the effect on colonic bacteria of NUTRIOSE® 10, 15 or 20 g/day administered for 14 days was examined; in study 2, gut microbial changes in response to NUTRIOSE® 8 g/day for 14 days were monitored using real-time polymerase chain reaction analysis. RESULTS: NUTRIOSE® increased proliferation of Bacteroides and inhibited Clostridum perfringens in both studies, increased β-glucosidase activity (at 10 and 15 g/day) and decreased colonic pH (at 20 g/day). The increase in short-chain fatty acid production with NUTRIOSE® consumption was not statistically significant. There were no indications of gastrointestinal intolerance at any dose. CONCLUSIONS: According to commonly accepted definitions, NUTRIOSE® is a prebiotic soluble fibre that provides a beneficial effect on colonic ecology while preserving digestive comfort.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Bacteroides - drug effects</subject><subject>Bacteroides - growth & development</subject><subject>Clostridium perfringens - drug effects</subject><subject>Colony Count, Microbial</subject><subject>Dextrins - administration & dosage</subject><subject>Dextrins - pharmacology</subject><subject>Dietary Fiber</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Health</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration - drug effects</subject><subject>Intestines - drug effects</subject><subject>Intestines - microbiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prebiotics</subject><subject>Solubility - drug effects</subject><issn>0300-0605</issn><issn>1473-2300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxi1ERZfCC3BAvnFpqOM4TsyttFt2pZai_jlHjjPedeXEi-3Q7kv1wCPwZHW0pRckpJG-0eg332j0IfQhJ5_zvKqOclYVtCAkp4SRSegrNJuG2TR9jWYkSUY4KffR2xDuCGGUl_QN2qeUUVHwfIZ-L_uNVBE7jSW-gmBClEPEp_AQvRmwG_ByiBCiGaTFc-WsW22_4IW7x8c2QkJWOK4Bn5rVBP2CiQnbEKHH9yau8ffbm6vl5fX8z-NhOnDt7NhawGem9bADfnhojYtGpc5twEcD4RBfyC3-CqkG0EaZdFs7jxcgbVy_Q3ta2gDvn_UA3Z7Nb04W2fnlt-XJ8XmmiprHrCU1F5pDq0F0VV3Solaaya6oSaUFsE4o3QEVrQItO1aVtW5ZyQjTgnYi58UB-rTz3Xj3c0zvNb0JCqyVA7gxNIKKknDOWCLpjlTeheBBNxtveum3TU6aKarm36jS0sdn-7HtoXtZ-ZtNAo52QJAraO7c6FMG4X-WT-wBnhU</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Lefranc-Millot, C</creator><creator>Guérin-Deremaux, L</creator><creator>Wils, D</creator><creator>Neut, C</creator><creator>Miller, LE</creator><creator>Saniez-Degrave, MH</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>Impact of a Resistant Dextrin on Intestinal Ecology: How Altering the Digestive Ecosystem with NUTRIOSE®, a Soluble Fibre with Prebiotic Properties, May Be Beneficial for Health</title><author>Lefranc-Millot, C ; Guérin-Deremaux, L ; Wils, D ; Neut, C ; Miller, LE ; Saniez-Degrave, MH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-b0869f6ebfe9d785238cf4ad3807f9e4d9cfde29bcefad4758fb45404f92d9163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Bacteroides - drug effects</topic><topic>Bacteroides - growth & development</topic><topic>Clostridium perfringens - drug effects</topic><topic>Colony Count, Microbial</topic><topic>Dextrins - administration & dosage</topic><topic>Dextrins - pharmacology</topic><topic>Dietary Fiber</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Health</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration - drug effects</topic><topic>Intestines - drug effects</topic><topic>Intestines - microbiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prebiotics</topic><topic>Solubility - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lefranc-Millot, C</creatorcontrib><creatorcontrib>Guérin-Deremaux, L</creatorcontrib><creatorcontrib>Wils, D</creatorcontrib><creatorcontrib>Neut, C</creatorcontrib><creatorcontrib>Miller, LE</creatorcontrib><creatorcontrib>Saniez-Degrave, MH</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of international medical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Lefranc-Millot, C</au><au>Guérin-Deremaux, L</au><au>Wils, D</au><au>Neut, C</au><au>Miller, LE</au><au>Saniez-Degrave, MH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of a Resistant Dextrin on Intestinal Ecology: How Altering the Digestive Ecosystem with NUTRIOSE®, a Soluble Fibre with Prebiotic Properties, May Be Beneficial for Health</atitle><jtitle>Journal of international medical research</jtitle><addtitle>J Int Med Res</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>40</volume><issue>1</issue><spage>211</spage><epage>224</epage><pages>211-224</pages><issn>0300-0605</issn><eissn>1473-2300</eissn><abstract>OBJECTIVES: The prebiotic potential of NUTRIOSE® – a sugar-free, digestion-resistant dextrin — was evaluated in two randomized, placebo-controlled trials that included 48 and 40 healthy volunteers, respectively. 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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Administration, Oral Adult Bacteroides - drug effects Bacteroides - growth & development Clostridium perfringens - drug effects Colony Count, Microbial Dextrins - administration & dosage Dextrins - pharmacology Dietary Fiber Feces - microbiology Female Health Humans Hydrogen-Ion Concentration - drug effects Intestines - drug effects Intestines - microbiology Male Middle Aged Prebiotics Solubility - drug effects |
| title | Impact of a Resistant Dextrin on Intestinal Ecology: How Altering the Digestive Ecosystem with NUTRIOSE®, a Soluble Fibre with Prebiotic Properties, May Be Beneficial for Health |
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