Targeted Drug Regulation on Methylation of p53—BAX Mitochondrial Apoptosis Pathway Affects the Growth of Cholangiocarcinoma Cells

OBJECTIVE: To study the mechanism of 5-aza-2-deoxycytidine (DAC; a methylation inhibitor) on growth of the human cholangiocarcinoma QBC939 cell line. METHODS: A colourimetric assay was used to detect growth of QBC939 cells treated with DAC (0.1 – 100 μmol/l) over 24 h, 48 h and 72 h. Cell morphology...

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Veröffentlicht in:	Journal of international medical research 2012-02, Vol.40 (1), p.67-75
Hauptverfasser:	Liu, X-F, Jiang, H, Zhang, C-S, Yu, S-P, Wang, Z-Q, Su, H-L
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - genetics Azacitidine - pharmacology bcl-2-Associated X Protein - genetics Cell Line, Tumor Cell Proliferation - drug effects Cholangiocarcinoma - genetics Cholangiocarcinoma - pathology Cholangiocarcinoma - ultrastructure DNA Methylation - drug effects DNA Methylation - genetics Humans Mitochondria - drug effects Mitochondria - genetics Promoter Regions, Genetic - genetics Signal Transduction - drug effects Signal Transduction - genetics Tumor Suppressor Protein p53 - genetics
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