Unfavourable consequences of chronic cardiac HIF-1α stabilization

The hypoxia-inducible factor-1 (HIF-1) is the master modulator of hypoxic gene expression. The effects of chronically stabilized cardiac HIF-1α and its role in the diseased heart are not precisely known. The aims of this study were as follows: (i) to elucidate consequences of HIF-1α stabilization in...

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Veröffentlicht in:	Cardiovascular research 2012-04, Vol.94 (1), p.77-86
Hauptverfasser:	HÖLSCHER, Marion, SCHÄFER, Katrin, MAIER, Lars S, KATSCHINSKI, Dörthe M, ZIESENISS, Anke, KRULL, Sabine, FARHAT, Katja, HESSE, Amke, SITTER, Monique, YUN LIN, PICHLER, Bernd J, THISTLETHWAITE, Patricia, EL-ARMOUCHE, Ali
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Biological and medical sciences Calcium Signaling - genetics Calcium-Binding Proteins - metabolism Capillaries - metabolism Cardiology. Vascular system Cardiomyopathies - genetics Cardiomyopathies - metabolism Cardiomyopathies - physiopathology Disease Models, Animal Disease Progression Gene Expression Regulation Glucose - metabolism Glycolysis - genetics Heart Heart Failure - genetics Heart Failure - metabolism Heart Failure - physiopathology Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Medical sciences Mice Mice, Transgenic Myocarditis. Cardiomyopathies Myocytes, Cardiac - metabolism Phosphorylation Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism Time Factors Up-Regulation Ventricular Function, Left
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