Cognitive function in patients with decompensated heart failure: the Cognitive Impairment in Heart Failure (CogImpair-HF) study
Aims The objective of this study was to examine cognitive and psychological processes systematically in patients with decompensated chronic heart failure (CHF) and to document changes in cognitive function after compensation. Executive functions, episodic memory, and attention are impaired in patien...
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| Veröffentlicht in: | European journal of heart failure 2012-04, Vol.14 (4), p.404-413 |
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| container_title | European journal of heart failure |
| container_volume | 14 |
| creator | Kindermann, Ingrid Fischer, Denise Karbach, Julia Link, Andreas Walenta, Katrin Barth, Christine Ukena, Christian Mahfoud, Felix Köllner, Volker Kindermann, Michael Böhm, Michael |
| description | Aims
The objective of this study was to examine cognitive and psychological processes systematically in patients with decompensated chronic heart failure (CHF) and to document changes in cognitive function after compensation. Executive functions, episodic memory, and attention are impaired in patients with stable CHF, influencing health behaviour and disease management. Cognitive function and psychological co‐morbidities are associated with hospitalization, disability, and mortality.
Methods and results
Cognitive performance, self‐perceived quality of life, and depression were compared in 20 patients with decompensated CHF [ejection fraction (EF) 27 ± 8%, N‐terminal pro brain natriuretic peptide (NT‐proBNP) 10 880 pg/mL, interquartile range (4495–13 683)] before and after compensation, 20 age‐ and gender‐matched stable CHF patients [New York Heart Assocation (NYHA) III–IV, EF 32 ± 10%, NT‐proBNP 1881 pg/mL (323–1502)], and 20 healthy controls (EF 70 ± 5%). Patients with decompensated CHF showed significantly poorer performance in terms of short‐term memory, working memory, executive control, and processing speed (P < 0.05) compared with stable CHF patients. Compensation improved the cognitive performance of decompensated CHF patients up to the level of patients with stable CHF. Compared with healthy controls, both patient groups were affected with respect to episodic memory (P < 0.0001) and fluid intelligence (P < 0.01).
Conclusion
Decompensated heart failure patients are highly impaired in cognitive functioning, which improves but does not normalize after compensation. Neuropsychological diagnostics delivers important details for daily life activities and might identify individuals deserving special care. |
| doi_str_mv | 10.1093/eurjhf/hfs015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_929503330</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>929503330</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4155-8e4a59048c5681f27d20701e7b9adc49fb2783fbc0f8fc6f31bf4c811da7e93a3</originalsourceid><addsrcrecordid>eNp9kDtz1TAQRjUMDHlAScuoIylMJEu-kumSSxznARRchlIjyyus4BeSTLgVfx0nvoSOandmz3dm50PoFSVvKcnZCUz-trEnjQ2EZk_QPpUiT4jk_Om8MymTXPJ0Dx2EcEsIFYSkz9FemnJGOVnto9_r4VvvovsJ2E69iW7osevxqKODPgZ852KDazBDN0IfdIQaN6B9xFa7dvLwDscG8D_JZTdq57s5e68pH9BiQfHRjC33pCyOcYhTvX2BnlndBni5m4foS3G-WZfJzaeLy_XpTWI4zbJEAtdZTrg02UpSm4o6JYJQEFWua8NzW6VCMlsZYqU1K8toZbmRlNZaQM40O0RvFu_ohx8ThKg6Fwy0re5hmILK0zwjjDEyk8lCGj-E4MGq0btO-62iRN1XrpbK1VL5zL_emaeqg_qR_tvxDGQLcOda2P7fps6vyqIsPi_i3SMuRPj1mNP-u1oJJjL19eOF2px9kFfvN0Rdsz--_KFI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>929503330</pqid></control><display><type>article</type><title>Cognitive function in patients with decompensated heart failure: the Cognitive Impairment in Heart Failure (CogImpair-HF) study</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><source>Alma/SFX Local Collection</source><creator>Kindermann, Ingrid ; Fischer, Denise ; Karbach, Julia ; Link, Andreas ; Walenta, Katrin ; Barth, Christine ; Ukena, Christian ; Mahfoud, Felix ; Köllner, Volker ; Kindermann, Michael ; Böhm, Michael</creator><creatorcontrib>Kindermann, Ingrid ; Fischer, Denise ; Karbach, Julia ; Link, Andreas ; Walenta, Katrin ; Barth, Christine ; Ukena, Christian ; Mahfoud, Felix ; Köllner, Volker ; Kindermann, Michael ; Böhm, Michael</creatorcontrib><description>Aims
The objective of this study was to examine cognitive and psychological processes systematically in patients with decompensated chronic heart failure (CHF) and to document changes in cognitive function after compensation. Executive functions, episodic memory, and attention are impaired in patients with stable CHF, influencing health behaviour and disease management. Cognitive function and psychological co‐morbidities are associated with hospitalization, disability, and mortality.
Methods and results
Cognitive performance, self‐perceived quality of life, and depression were compared in 20 patients with decompensated CHF [ejection fraction (EF) 27 ± 8%, N‐terminal pro brain natriuretic peptide (NT‐proBNP) 10 880 pg/mL, interquartile range (4495–13 683)] before and after compensation, 20 age‐ and gender‐matched stable CHF patients [New York Heart Assocation (NYHA) III–IV, EF 32 ± 10%, NT‐proBNP 1881 pg/mL (323–1502)], and 20 healthy controls (EF 70 ± 5%). Patients with decompensated CHF showed significantly poorer performance in terms of short‐term memory, working memory, executive control, and processing speed (P < 0.05) compared with stable CHF patients. Compensation improved the cognitive performance of decompensated CHF patients up to the level of patients with stable CHF. Compared with healthy controls, both patient groups were affected with respect to episodic memory (P < 0.0001) and fluid intelligence (P < 0.01).
Conclusion
Decompensated heart failure patients are highly impaired in cognitive functioning, which improves but does not normalize after compensation. Neuropsychological diagnostics delivers important details for daily life activities and might identify individuals deserving special care.</description><identifier>ISSN: 1388-9842</identifier><identifier>EISSN: 1879-0844</identifier><identifier>DOI: 10.1093/eurjhf/hfs015</identifier><identifier>PMID: 22431406</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Analysis of Variance ; Cardiac decompensation ; Chi-Square Distribution ; Cognition ; Cognition - physiology ; Cognition Disorders - etiology ; Cognition Disorders - psychology ; Depression ; Depression - etiology ; Depression - psychology ; Female ; Health Status Indicators ; Heart failure ; Heart Failure - complications ; Heart Failure - psychology ; Hospitalization ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Quality of life ; Quality of Life - psychology ; Stroke Volume ; Ventricular Function, Left</subject><ispartof>European journal of heart failure, 2012-04, Vol.14 (4), p.404-413</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © 2012 the Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4155-8e4a59048c5681f27d20701e7b9adc49fb2783fbc0f8fc6f31bf4c811da7e93a3</citedby><cites>FETCH-LOGICAL-c4155-8e4a59048c5681f27d20701e7b9adc49fb2783fbc0f8fc6f31bf4c811da7e93a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1093%2Feurjhf%2Fhfs015$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1093%2Feurjhf%2Fhfs015$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,1435,27933,27934,45583,45584,46418,46842</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22431406$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kindermann, Ingrid</creatorcontrib><creatorcontrib>Fischer, Denise</creatorcontrib><creatorcontrib>Karbach, Julia</creatorcontrib><creatorcontrib>Link, Andreas</creatorcontrib><creatorcontrib>Walenta, Katrin</creatorcontrib><creatorcontrib>Barth, Christine</creatorcontrib><creatorcontrib>Ukena, Christian</creatorcontrib><creatorcontrib>Mahfoud, Felix</creatorcontrib><creatorcontrib>Köllner, Volker</creatorcontrib><creatorcontrib>Kindermann, Michael</creatorcontrib><creatorcontrib>Böhm, Michael</creatorcontrib><title>Cognitive function in patients with decompensated heart failure: the Cognitive Impairment in Heart Failure (CogImpair-HF) study</title><title>European journal of heart failure</title><addtitle>European Journal of Heart Failure</addtitle><description>Aims
The objective of this study was to examine cognitive and psychological processes systematically in patients with decompensated chronic heart failure (CHF) and to document changes in cognitive function after compensation. Executive functions, episodic memory, and attention are impaired in patients with stable CHF, influencing health behaviour and disease management. Cognitive function and psychological co‐morbidities are associated with hospitalization, disability, and mortality.
Methods and results
Cognitive performance, self‐perceived quality of life, and depression were compared in 20 patients with decompensated CHF [ejection fraction (EF) 27 ± 8%, N‐terminal pro brain natriuretic peptide (NT‐proBNP) 10 880 pg/mL, interquartile range (4495–13 683)] before and after compensation, 20 age‐ and gender‐matched stable CHF patients [New York Heart Assocation (NYHA) III–IV, EF 32 ± 10%, NT‐proBNP 1881 pg/mL (323–1502)], and 20 healthy controls (EF 70 ± 5%). Patients with decompensated CHF showed significantly poorer performance in terms of short‐term memory, working memory, executive control, and processing speed (P < 0.05) compared with stable CHF patients. Compensation improved the cognitive performance of decompensated CHF patients up to the level of patients with stable CHF. Compared with healthy controls, both patient groups were affected with respect to episodic memory (P < 0.0001) and fluid intelligence (P < 0.01).
Conclusion
Decompensated heart failure patients are highly impaired in cognitive functioning, which improves but does not normalize after compensation. Neuropsychological diagnostics delivers important details for daily life activities and might identify individuals deserving special care.</description><subject>Analysis of Variance</subject><subject>Cardiac decompensation</subject><subject>Chi-Square Distribution</subject><subject>Cognition</subject><subject>Cognition - physiology</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - psychology</subject><subject>Depression</subject><subject>Depression - etiology</subject><subject>Depression - psychology</subject><subject>Female</subject><subject>Health Status Indicators</subject><subject>Heart failure</subject><subject>Heart Failure - complications</subject><subject>Heart Failure - psychology</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Quality of life</subject><subject>Quality of Life - psychology</subject><subject>Stroke Volume</subject><subject>Ventricular Function, Left</subject><issn>1388-9842</issn><issn>1879-0844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtz1TAQRjUMDHlAScuoIylMJEu-kumSSxznARRchlIjyyus4BeSTLgVfx0nvoSOandmz3dm50PoFSVvKcnZCUz-trEnjQ2EZk_QPpUiT4jk_Om8MymTXPJ0Dx2EcEsIFYSkz9FemnJGOVnto9_r4VvvovsJ2E69iW7osevxqKODPgZ852KDazBDN0IfdIQaN6B9xFa7dvLwDscG8D_JZTdq57s5e68pH9BiQfHRjC33pCyOcYhTvX2BnlndBni5m4foS3G-WZfJzaeLy_XpTWI4zbJEAtdZTrg02UpSm4o6JYJQEFWua8NzW6VCMlsZYqU1K8toZbmRlNZaQM40O0RvFu_ohx8ThKg6Fwy0re5hmILK0zwjjDEyk8lCGj-E4MGq0btO-62iRN1XrpbK1VL5zL_emaeqg_qR_tvxDGQLcOda2P7fps6vyqIsPi_i3SMuRPj1mNP-u1oJJjL19eOF2px9kFfvN0Rdsz--_KFI</recordid><startdate>201204</startdate><enddate>201204</enddate><creator>Kindermann, Ingrid</creator><creator>Fischer, Denise</creator><creator>Karbach, Julia</creator><creator>Link, Andreas</creator><creator>Walenta, Katrin</creator><creator>Barth, Christine</creator><creator>Ukena, Christian</creator><creator>Mahfoud, Felix</creator><creator>Köllner, Volker</creator><creator>Kindermann, Michael</creator><creator>Böhm, Michael</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201204</creationdate><title>Cognitive function in patients with decompensated heart failure: the Cognitive Impairment in Heart Failure (CogImpair-HF) study</title><author>Kindermann, Ingrid ; Fischer, Denise ; Karbach, Julia ; Link, Andreas ; Walenta, Katrin ; Barth, Christine ; Ukena, Christian ; Mahfoud, Felix ; Köllner, Volker ; Kindermann, Michael ; Böhm, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4155-8e4a59048c5681f27d20701e7b9adc49fb2783fbc0f8fc6f31bf4c811da7e93a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Analysis of Variance</topic><topic>Cardiac decompensation</topic><topic>Chi-Square Distribution</topic><topic>Cognition</topic><topic>Cognition - physiology</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - psychology</topic><topic>Depression</topic><topic>Depression - etiology</topic><topic>Depression - psychology</topic><topic>Female</topic><topic>Health Status Indicators</topic><topic>Heart failure</topic><topic>Heart Failure - complications</topic><topic>Heart Failure - psychology</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Quality of life</topic><topic>Quality of Life - psychology</topic><topic>Stroke Volume</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kindermann, Ingrid</creatorcontrib><creatorcontrib>Fischer, Denise</creatorcontrib><creatorcontrib>Karbach, Julia</creatorcontrib><creatorcontrib>Link, Andreas</creatorcontrib><creatorcontrib>Walenta, Katrin</creatorcontrib><creatorcontrib>Barth, Christine</creatorcontrib><creatorcontrib>Ukena, Christian</creatorcontrib><creatorcontrib>Mahfoud, Felix</creatorcontrib><creatorcontrib>Köllner, Volker</creatorcontrib><creatorcontrib>Kindermann, Michael</creatorcontrib><creatorcontrib>Böhm, Michael</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of heart failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kindermann, Ingrid</au><au>Fischer, Denise</au><au>Karbach, Julia</au><au>Link, Andreas</au><au>Walenta, Katrin</au><au>Barth, Christine</au><au>Ukena, Christian</au><au>Mahfoud, Felix</au><au>Köllner, Volker</au><au>Kindermann, Michael</au><au>Böhm, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive function in patients with decompensated heart failure: the Cognitive Impairment in Heart Failure (CogImpair-HF) study</atitle><jtitle>European journal of heart failure</jtitle><addtitle>European Journal of Heart Failure</addtitle><date>2012-04</date><risdate>2012</risdate><volume>14</volume><issue>4</issue><spage>404</spage><epage>413</epage><pages>404-413</pages><issn>1388-9842</issn><eissn>1879-0844</eissn><abstract>Aims
The objective of this study was to examine cognitive and psychological processes systematically in patients with decompensated chronic heart failure (CHF) and to document changes in cognitive function after compensation. Executive functions, episodic memory, and attention are impaired in patients with stable CHF, influencing health behaviour and disease management. Cognitive function and psychological co‐morbidities are associated with hospitalization, disability, and mortality.
Methods and results
Cognitive performance, self‐perceived quality of life, and depression were compared in 20 patients with decompensated CHF [ejection fraction (EF) 27 ± 8%, N‐terminal pro brain natriuretic peptide (NT‐proBNP) 10 880 pg/mL, interquartile range (4495–13 683)] before and after compensation, 20 age‐ and gender‐matched stable CHF patients [New York Heart Assocation (NYHA) III–IV, EF 32 ± 10%, NT‐proBNP 1881 pg/mL (323–1502)], and 20 healthy controls (EF 70 ± 5%). Patients with decompensated CHF showed significantly poorer performance in terms of short‐term memory, working memory, executive control, and processing speed (P < 0.05) compared with stable CHF patients. Compensation improved the cognitive performance of decompensated CHF patients up to the level of patients with stable CHF. Compared with healthy controls, both patient groups were affected with respect to episodic memory (P < 0.0001) and fluid intelligence (P < 0.01).
Conclusion
Decompensated heart failure patients are highly impaired in cognitive functioning, which improves but does not normalize after compensation. Neuropsychological diagnostics delivers important details for daily life activities and might identify individuals deserving special care.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>22431406</pmid><doi>10.1093/eurjhf/hfs015</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1388-9842 |
| ispartof | European journal of heart failure, 2012-04, Vol.14 (4), p.404-413 |
| issn | 1388-9842 1879-0844 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); Alma/SFX Local Collection |
| subjects | Analysis of Variance Cardiac decompensation Chi-Square Distribution Cognition Cognition - physiology Cognition Disorders - etiology Cognition Disorders - psychology Depression Depression - etiology Depression - psychology Female Health Status Indicators Heart failure Heart Failure - complications Heart Failure - psychology Hospitalization Humans Male Middle Aged Neuropsychological Tests Quality of life Quality of Life - psychology Stroke Volume Ventricular Function, Left |
| title | Cognitive function in patients with decompensated heart failure: the Cognitive Impairment in Heart Failure (CogImpair-HF) study |
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