The many faces of insulin-like peptide signalling in the brain

Key Points Insulin-like peptides (ILPs), which comprise insulin, insulin-like growth factor 1 (IGF1) and IGF2, influence overall brain development by affecting proliferation, survival and differentiation of brain cells and by having modulatory roles in the refinement of brain circuitries. Peripheral...

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Veröffentlicht in:	Nature reviews. Neuroscience 2012-04, Vol.13 (4), p.225-239
Hauptverfasser:	Fernandez, Ana M., Torres-Alemán, Ignacio
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1697 631/378/340 631/80/86/2367 Animal Genetics and Genomics Animals Behavioral Sciences Bioavailability Biological and medical sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain Brain - metabolism Cellular signal transduction Cognition - physiology Energy Energy Metabolism - physiology Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Genetic aspects Health aspects Homeostasis Hormones Insulin Insulin - metabolism Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor II - metabolism Insulin-like growth factors Medical sciences Nervous system involvement in other diseases. Miscellaneous Neurobiology Neurogenetics Neurology Neuronal Plasticity - physiology Neurons - metabolism Neurosciences Peptides Proteins review-article Rodents Vertebrates: nervous system and sense organs
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