Changes of NK Cells in Preeclampsia
The regulation of uterine and circulating peripheral blood natural killer (NK) cells has been associated with reproductive immunology such as recurrent pregnancy losses, implantation failures, or preeclampsia. Preeclampsia is a hypertensive disorder of pregnancy characterized by increased blood pres...
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| Veröffentlicht in: | American journal of reproductive immunology (1989) 2012-04, Vol.67 (4), p.278-286 |
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| container_title | American journal of reproductive immunology (1989) |
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| creator | Fukui, Atsushi Yokota, Megumi Funamizu, Ayano Nakamua, Rika Fukuhara, Rie Yamada, Kenichi Kimura, Hidetaka Fukuyama, Asami Kamoi, Mai Tanaka, Kanji Mizunuma, Hideki |
| description | The regulation of uterine and circulating peripheral blood natural killer (NK) cells has been associated with reproductive immunology such as recurrent pregnancy losses, implantation failures, or preeclampsia. Preeclampsia is a hypertensive disorder of pregnancy characterized by increased blood pressure accompanied by proteinuria and is a major cause of maternal and fetal mortality. Natural cytotoxicity receptors (NCRs) are unique markers, which regulate NK cell cytotoxicity and cytokine production. The relation of NCRs to reproduction is not fully characterized yet. The different profile of NCRs expression may suggest presence of abnormal regulation of NK cell in women with reproductive failures. Pregnant women with preeclampsia carry immunological abnormalities of NCRs on peripheral blood NK cells during pregnancy. The lower expression of NKp46+ NK cells in women with preeclampsia may account for the higher production of NK1 cytokine that is known as NK1 shift in pregnant women with preeclampsia. Evaluation of NKp46 on peripheral blood NK cells may be applicable to find the onset of preeclampsia. In this review, various expressions of NK cell surface markers including NCRs on NK cells, NK cell cytotoxicity, and production of cytokines and angiogenic factors by NK cells were reviewed in relation to preeclampsia. |
| doi_str_mv | 10.1111/j.1600-0897.2012.01120.x |
| format | Article |
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Preeclampsia is a hypertensive disorder of pregnancy characterized by increased blood pressure accompanied by proteinuria and is a major cause of maternal and fetal mortality. Natural cytotoxicity receptors (NCRs) are unique markers, which regulate NK cell cytotoxicity and cytokine production. The relation of NCRs to reproduction is not fully characterized yet. The different profile of NCRs expression may suggest presence of abnormal regulation of NK cell in women with reproductive failures. Pregnant women with preeclampsia carry immunological abnormalities of NCRs on peripheral blood NK cells during pregnancy. The lower expression of NKp46+ NK cells in women with preeclampsia may account for the higher production of NK1 cytokine that is known as NK1 shift in pregnant women with preeclampsia. Evaluation of NKp46 on peripheral blood NK cells may be applicable to find the onset of preeclampsia. 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Preeclampsia is a hypertensive disorder of pregnancy characterized by increased blood pressure accompanied by proteinuria and is a major cause of maternal and fetal mortality. Natural cytotoxicity receptors (NCRs) are unique markers, which regulate NK cell cytotoxicity and cytokine production. The relation of NCRs to reproduction is not fully characterized yet. The different profile of NCRs expression may suggest presence of abnormal regulation of NK cell in women with reproductive failures. Pregnant women with preeclampsia carry immunological abnormalities of NCRs on peripheral blood NK cells during pregnancy. The lower expression of NKp46+ NK cells in women with preeclampsia may account for the higher production of NK1 cytokine that is known as NK1 shift in pregnant women with preeclampsia. Evaluation of NKp46 on peripheral blood NK cells may be applicable to find the onset of preeclampsia. In this review, various expressions of NK cell surface markers including NCRs on NK cells, NK cell cytotoxicity, and production of cytokines and angiogenic factors by NK cells were reviewed in relation to preeclampsia.</description><subject>Abortion</subject><subject>Abortion, Habitual - immunology</subject><subject>Angiogenesis</subject><subject>Antigens, Surface - metabolism</subject><subject>Blood pressure</subject><subject>CD56 Antigen - immunology</subject><subject>CD56 Antigen - metabolism</subject><subject>cytokine</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Cytotoxicity</subject><subject>Embryo Implantation - immunology</subject><subject>Female</subject><subject>Fetuses</subject><subject>Humans</subject><subject>Killer Cells, Natural - immunology</subject><subject>Killer Cells, Natural - metabolism</subject><subject>Mortality</subject><subject>natural cytotoxicity receptor</subject><subject>Natural Cytotoxicity Triggering Receptor 1 - metabolism</subject><subject>Natural killer cells</subject><subject>NK cell</subject><subject>NKp46</subject><subject>Peripheral blood</subject><subject>Pre-eclampsia</subject><subject>Pre-Eclampsia - immunology</subject><subject>Pre-Eclampsia - metabolism</subject><subject>preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - immunology</subject><subject>Proteinuria</subject><subject>Receptors, Natural Cytotoxicity Triggering - metabolism</subject><subject>Reproduction</subject><subject>Reproductive failure</subject><subject>Reviews</subject><subject>Surface markers</subject><subject>Uterus</subject><issn>1046-7408</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0EoqXwCygSC9gkjF-xs2BRRdAWqgISCImNlccEUtIHcSvav8ehpUuENx7Z587YhxCPQkDduhwHNATwQUcqYEBZAJQyCFZ7pL272Hc1iNBXAnSLHFk7BnDnXB2SFmM8FIyzNjmL35PpG1pvVnijOy_GqrJeOfUeasSsSiZzWybH5KBIKosn271Dnm-un-K-P7zvDeLu0M8kSPCLiOUqlUmeS4qoWaZzmkqesrTgLJWoMeWgGUa5EAqpBuC54iySKuRURQXvkPNN33k9-1yiXZhJaTP3omSKs6U1kWOBSSEcefEnSd1PNdeCRw7VGzSrZ9bWWJh5XU6Seu0g08g0Y9M4M40z08g0PzLNykVPt1OW6QTzXfDXngOuNsBXWeH6341N93bQVC7vb_KlXeBql0_qDxMqrqR5GfWM7MPjq5DcxPwbZCmNww</recordid><startdate>201204</startdate><enddate>201204</enddate><creator>Fukui, Atsushi</creator><creator>Yokota, Megumi</creator><creator>Funamizu, Ayano</creator><creator>Nakamua, Rika</creator><creator>Fukuhara, Rie</creator><creator>Yamada, Kenichi</creator><creator>Kimura, Hidetaka</creator><creator>Fukuyama, Asami</creator><creator>Kamoi, Mai</creator><creator>Tanaka, Kanji</creator><creator>Mizunuma, Hideki</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201204</creationdate><title>Changes of NK Cells in Preeclampsia</title><author>Fukui, Atsushi ; Yokota, Megumi ; Funamizu, Ayano ; Nakamua, Rika ; Fukuhara, Rie ; Yamada, Kenichi ; Kimura, Hidetaka ; Fukuyama, Asami ; Kamoi, Mai ; Tanaka, Kanji ; Mizunuma, Hideki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5050-f92d7b5add51ee82c8d1b53b2bf32b5e8eb3082e9d447e18003d73295763179f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abortion</topic><topic>Abortion, Habitual - immunology</topic><topic>Angiogenesis</topic><topic>Antigens, Surface - metabolism</topic><topic>Blood pressure</topic><topic>CD56 Antigen - immunology</topic><topic>CD56 Antigen - metabolism</topic><topic>cytokine</topic><topic>Cytokines</topic><topic>Cytokines - metabolism</topic><topic>Cytotoxicity</topic><topic>Embryo Implantation - immunology</topic><topic>Female</topic><topic>Fetuses</topic><topic>Humans</topic><topic>Killer Cells, Natural - immunology</topic><topic>Killer Cells, Natural - metabolism</topic><topic>Mortality</topic><topic>natural cytotoxicity receptor</topic><topic>Natural Cytotoxicity Triggering Receptor 1 - metabolism</topic><topic>Natural killer cells</topic><topic>NK cell</topic><topic>NKp46</topic><topic>Peripheral blood</topic><topic>Pre-eclampsia</topic><topic>Pre-Eclampsia - immunology</topic><topic>Pre-Eclampsia - metabolism</topic><topic>preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - immunology</topic><topic>Proteinuria</topic><topic>Receptors, Natural Cytotoxicity Triggering - metabolism</topic><topic>Reproduction</topic><topic>Reproductive failure</topic><topic>Reviews</topic><topic>Surface markers</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukui, Atsushi</creatorcontrib><creatorcontrib>Yokota, Megumi</creatorcontrib><creatorcontrib>Funamizu, Ayano</creatorcontrib><creatorcontrib>Nakamua, Rika</creatorcontrib><creatorcontrib>Fukuhara, Rie</creatorcontrib><creatorcontrib>Yamada, Kenichi</creatorcontrib><creatorcontrib>Kimura, Hidetaka</creatorcontrib><creatorcontrib>Fukuyama, Asami</creatorcontrib><creatorcontrib>Kamoi, Mai</creatorcontrib><creatorcontrib>Tanaka, Kanji</creatorcontrib><creatorcontrib>Mizunuma, Hideki</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukui, Atsushi</au><au>Yokota, Megumi</au><au>Funamizu, Ayano</au><au>Nakamua, Rika</au><au>Fukuhara, Rie</au><au>Yamada, Kenichi</au><au>Kimura, Hidetaka</au><au>Fukuyama, Asami</au><au>Kamoi, Mai</au><au>Tanaka, Kanji</au><au>Mizunuma, Hideki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes of NK Cells in Preeclampsia</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>2012-04</date><risdate>2012</risdate><volume>67</volume><issue>4</issue><spage>278</spage><epage>286</epage><pages>278-286</pages><issn>1046-7408</issn><eissn>1600-0897</eissn><abstract>The regulation of uterine and circulating peripheral blood natural killer (NK) cells has been associated with reproductive immunology such as recurrent pregnancy losses, implantation failures, or preeclampsia. Preeclampsia is a hypertensive disorder of pregnancy characterized by increased blood pressure accompanied by proteinuria and is a major cause of maternal and fetal mortality. Natural cytotoxicity receptors (NCRs) are unique markers, which regulate NK cell cytotoxicity and cytokine production. The relation of NCRs to reproduction is not fully characterized yet. The different profile of NCRs expression may suggest presence of abnormal regulation of NK cell in women with reproductive failures. Pregnant women with preeclampsia carry immunological abnormalities of NCRs on peripheral blood NK cells during pregnancy. The lower expression of NKp46+ NK cells in women with preeclampsia may account for the higher production of NK1 cytokine that is known as NK1 shift in pregnant women with preeclampsia. Evaluation of NKp46 on peripheral blood NK cells may be applicable to find the onset of preeclampsia. In this review, various expressions of NK cell surface markers including NCRs on NK cells, NK cell cytotoxicity, and production of cytokines and angiogenic factors by NK cells were reviewed in relation to preeclampsia.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>22364232</pmid><doi>10.1111/j.1600-0897.2012.01120.x</doi><tpages>9</tpages></addata></record> |
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| ispartof | American journal of reproductive immunology (1989), 2012-04, Vol.67 (4), p.278-286 |
| issn | 1046-7408 1600-0897 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Abortion Abortion, Habitual - immunology Angiogenesis Antigens, Surface - metabolism Blood pressure CD56 Antigen - immunology CD56 Antigen - metabolism cytokine Cytokines Cytokines - metabolism Cytotoxicity Embryo Implantation - immunology Female Fetuses Humans Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Mortality natural cytotoxicity receptor Natural Cytotoxicity Triggering Receptor 1 - metabolism Natural killer cells NK cell NKp46 Peripheral blood Pre-eclampsia Pre-Eclampsia - immunology Pre-Eclampsia - metabolism preeclampsia Pregnancy Pregnancy Complications - immunology Proteinuria Receptors, Natural Cytotoxicity Triggering - metabolism Reproduction Reproductive failure Reviews Surface markers Uterus |
| title | Changes of NK Cells in Preeclampsia |
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