Biochemical and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2

The three-dimensional structure of hexameric glutamate dehydrogenase 2 of the malaria parasite Plasmodium falciparum was solved. This potential drug target localizes to the apicoplast. [Display omitted] ► Glutamate dehydrogenase 2 of Plasmodium (PfGDH2) was characterized. ► The three-dimensional str...

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Veröffentlicht in:	Molecular and biochemical parasitology 2012-05, Vol.183 (1), p.52-62
Hauptverfasser:	Zocher, Kathleen, Fritz-Wolf, Karin, Kehr, Sebastian, Fischer, Marina, Rahlfs, Stefan, Becker, Katja
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Amino Acid Sequence amino acids antimalarials Bithionol - chemistry cattle Cloning, Molecular Crystallography, X-Ray Drug target energy metabolism Gene Expression glutamate dehydrogenase Glutamate Dehydrogenase - antagonists & inhibitors Glutamate Dehydrogenase - chemistry Glutamate Dehydrogenase - genetics Glutamate Dehydrogenase - metabolism green fluorescent protein Green Fluorescent Proteins - chemistry Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism hexachlorophene Hexachlorophene - chemistry hydrogen bonding hydrophobic bonding Indoles - chemistry isozymes Kinetics malaria Malaria parasite Molecular Sequence Data parasites parasitology Phenols - chemistry Plasmodium falciparum Plasmodium falciparum - enzymology Protein Binding Protein structure Protein Structure, Quaternary Protein Structure, Secondary Protein Structure, Tertiary Protein Transport Protozoan Proteins - antagonists & inhibitors Protozoan Proteins - chemistry Protozoan Proteins - genetics Protozoan Proteins - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Redox reactions Structural Homology, Protein Tricarboxylic acid metabolism
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