SPINDLIN1 promotes cancer cell proliferation through activation of WNT/TCF-4 signaling

SPINDLIN1, a new member of the SPIN/SSTY gene family, was first identified as a gene highly expressed in ovarian cancer cells. We have previously shown that it is involved in the process of spindle organization and chromosomal stability and plays a role in the development of cancer. Nevertheless, th...

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Veröffentlicht in:	Molecular cancer research 2012-03, Vol.10 (3), p.326-335
Hauptverfasser:	Wang, Jing-Xue, Zeng, Quan, Chen, Lin, Du, Ji-Chao, Yan, Xin-Long, Yuan, Hong-Feng, Zhai, Chao, Zhou, Jun-Nian, Jia, Ya-Li, Yue, Wen, Pei, Xue-Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Aurora Kinases Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism Cell Cycle Proteins - metabolism Cell Line, Tumor Cell Proliferation Female Humans Microtubule-Associated Proteins - metabolism Mutation - genetics Neoplasm Invasiveness Neoplasms - metabolism Neoplasms - pathology Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Phosphoproteins - metabolism Phosphorylation Phosphoserine - metabolism Protein Binding Protein-Serine-Threonine Kinases - metabolism Transcription Factor 4 Transcription Factors - metabolism Wnt Signaling Pathway
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