Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice

Abstract We previously reported that the anti-inflammatory cytokine interleukin (IL)-4 induced selective clearance of oligomeric β-amyloid (Aβ1–42 ) in rat primary type 2 microglial cells. For the present study, we investigated whether IL-4 and IL-13 could activate microglial cells to induce Aβ clea...

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Veröffentlicht in:	Neuroscience 2012-04, Vol.207, p.243-260
Hauptverfasser:	Kawahara, K, Suenobu, M, Yoshida, A, Koga, K, Hyodo, A, Ohtsuka, H, Kuniyasu, A, Tamamaki, N, Sugimoto, Y, Nakayama, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Alzheimer Disease - genetics Alzheimer Disease - immunology Alzheimer Disease - therapy Alzheimer's disease Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Animals Biological and medical sciences CD36 Cognition Disorders - genetics Cognition Disorders - immunology Cognition Disorders - therapy Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Fundamental and applied biological sciences. Psychology Humans Injections, Intraventricular Interleukin-13 - administration & dosage Interleukin-13 - physiology Interleukin-4 - administration & dosage Interleukin-4 - physiology interleukin-4/interleukin-13 Male Medical sciences memory improvement Mice Mice, Inbred C57BL Mice, Transgenic Microinjections neprilysin Neurology Plaque, Amyloid - immunology Plaque, Amyloid - pathology Plaque, Amyloid - therapy Vertebrates: nervous system and sense organs β-amyloid
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