New losartan-hydrocaffeic acid hybrids as antihypertensive-antioxidant dual drugs: Ester, amide and amine linkers

We report new examples of a series of losartan–hydrocaffeic hybrids that bear novel ester, amide and amine linkers. These compounds were made by linking hydrocaffeic acid to the side chain of losartan at the C-5 position of the imidazole ring through different strategies. Experiments performed in cu...

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Veröffentlicht in:	European journal of medicinal chemistry 2012-04, Vol.50, p.90-101
Hauptverfasser:	García, Gonzalo, Serrano, Isabel, Sánchez-Alonso, Patricia, Rodríguez-Puyol, Manuel, Alajarín, Ramón, Griera, Mercedes, Vaquero, Juan J., Rodríguez-Puyol, Diego, Álvarez-Builla, Julio, Díez-Marqués, María L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Amides - metabolism Amines - chemistry Amines - metabolism Angiotensin II - pharmacology Animals Antihypertensive Antihypertensive agents Antihypertensive Agents - chemical synthesis Antihypertensive Agents - pharmacology Antioxidant Antioxidants - chemical synthesis Antioxidants - pharmacology Aorta, Thoracic - cytology Aorta, Thoracic - drug effects Biological and medical sciences Caffeic Acids - chemistry Caffeic Acids - pharmacology Cardiovascular system Cells, Cultured Esters - chemistry Esters - metabolism General and cellular metabolism. Vitamins Hybrid drug Hydrocaffeic acid Hypertension - drug therapy Losartan Losartan - chemistry Losartan - pharmacology Male Medical sciences Molecular Structure Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Pharmacology. Drug treatments Rats Rats, Wistar Structure-Activity Relationship Vasoconstrictor Agents - pharmacology Vasodilator agents. Cerebral vasodilators
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