Role of microRNAs in kidney homeostasis and disease
MicroRNAs (miRNAs) are endogenous short (20–22 nucleotides) non-coding RNA molecules that mediate gene expression. This is an important regulatory mechanism to modulate fundamental cellular processes such as differentiation, proliferation, death, metabolism, and pathophysiology of many diseases. The...
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| Veröffentlicht in: | Kidney international 2012-04, Vol.81 (7), p.617-627 |
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| creator | Chandrasekaran, Karthikeyan Karolina, Dwi S. Sepramaniam, Sugunavathi Armugam, Arunmozhiarasi Marelyn Wintour, E. Bertram, John F. Jeyaseelan, Kandiah |
| description | MicroRNAs (miRNAs) are endogenous short (20–22 nucleotides) non-coding RNA molecules that mediate gene expression. This is an important regulatory mechanism to modulate fundamental cellular processes such as differentiation, proliferation, death, metabolism, and pathophysiology of many diseases. The miRNA expression profile of the kidney differs greatly from that of other organs, as well as between the different regions in the kidney. In kidneys, miRNAs are indispensable for development and homeostasis. In this review, we explore the involvement of miRNAs in the regulation of blood pressure, hormone, water, and ion balance pertaining to kidney homeostasis. We also highlight their importance in renal pathophysiology, such as in polycystic disease, diabetic nephropathy, nephrogenic diabetes insipidus, hypertension, renal cancer, and kidney fibrosis (epithelial–mesenchymal transition). In addition, we highlight the need for further investigations on miRNA-based studies in the development of diagnostic, prognostic, and therapeutic tools for renal diseases. |
| doi_str_mv | 10.1038/ki.2011.448 |
| format | Article |
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This is an important regulatory mechanism to modulate fundamental cellular processes such as differentiation, proliferation, death, metabolism, and pathophysiology of many diseases. The miRNA expression profile of the kidney differs greatly from that of other organs, as well as between the different regions in the kidney. In kidneys, miRNAs are indispensable for development and homeostasis. In this review, we explore the involvement of miRNAs in the regulation of blood pressure, hormone, water, and ion balance pertaining to kidney homeostasis. We also highlight their importance in renal pathophysiology, such as in polycystic disease, diabetic nephropathy, nephrogenic diabetes insipidus, hypertension, renal cancer, and kidney fibrosis (epithelial–mesenchymal transition). In addition, we highlight the need for further investigations on miRNA-based studies in the development of diagnostic, prognostic, and therapeutic tools for renal diseases.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1038/ki.2011.448</identifier><identifier>PMID: 22237749</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>Basingstoke: Elsevier Inc</publisher><subject>Animals ; aquaporin ; Biological and medical sciences ; blood pressure regulation ; Diabetic Nephropathies - genetics ; Diabetic Nephropathies - metabolism ; Fibrosis ; Gene Expression Profiling ; Homeostasis ; Humans ; Hypertension, Renal - genetics ; Hypertension, Renal - metabolism ; ion channel ; Kidney - growth & development ; Kidney - metabolism ; Kidney Diseases - genetics ; Kidney Diseases - metabolism ; Kidney Diseases - pathology ; Kidney Neoplasms - genetics ; Kidney Neoplasms - metabolism ; Medical sciences ; microRNAs ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Models, Biological ; Nephrology. Urinary tract diseases ; nephron ; Nephropathies. Renovascular diseases. Renal failure ; Polycystic Kidney Diseases - genetics ; Polycystic Kidney Diseases - metabolism ; renal disease ; Renal failure</subject><ispartof>Kidney international, 2012-04, Vol.81 (7), p.617-627</ispartof><rights>2012 International Society of Nephrology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Apr 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-f2d760ec929908af9339bfddca8130c33c25e45f2eb60edde6438e8b67c946153</citedby><cites>FETCH-LOGICAL-c527t-f2d760ec929908af9339bfddca8130c33c25e45f2eb60edde6438e8b67c946153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25670072$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22237749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chandrasekaran, Karthikeyan</creatorcontrib><creatorcontrib>Karolina, Dwi S.</creatorcontrib><creatorcontrib>Sepramaniam, Sugunavathi</creatorcontrib><creatorcontrib>Armugam, Arunmozhiarasi</creatorcontrib><creatorcontrib>Marelyn Wintour, E.</creatorcontrib><creatorcontrib>Bertram, John F.</creatorcontrib><creatorcontrib>Jeyaseelan, Kandiah</creatorcontrib><title>Role of microRNAs in kidney homeostasis and disease</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>MicroRNAs (miRNAs) are endogenous short (20–22 nucleotides) non-coding RNA molecules that mediate gene expression. This is an important regulatory mechanism to modulate fundamental cellular processes such as differentiation, proliferation, death, metabolism, and pathophysiology of many diseases. The miRNA expression profile of the kidney differs greatly from that of other organs, as well as between the different regions in the kidney. In kidneys, miRNAs are indispensable for development and homeostasis. In this review, we explore the involvement of miRNAs in the regulation of blood pressure, hormone, water, and ion balance pertaining to kidney homeostasis. We also highlight their importance in renal pathophysiology, such as in polycystic disease, diabetic nephropathy, nephrogenic diabetes insipidus, hypertension, renal cancer, and kidney fibrosis (epithelial–mesenchymal transition). In addition, we highlight the need for further investigations on miRNA-based studies in the development of diagnostic, prognostic, and therapeutic tools for renal diseases.</description><subject>Animals</subject><subject>aquaporin</subject><subject>Biological and medical sciences</subject><subject>blood pressure regulation</subject><subject>Diabetic Nephropathies - genetics</subject><subject>Diabetic Nephropathies - metabolism</subject><subject>Fibrosis</subject><subject>Gene Expression Profiling</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hypertension, Renal - genetics</subject><subject>Hypertension, Renal - metabolism</subject><subject>ion channel</subject><subject>Kidney - growth & development</subject><subject>Kidney - metabolism</subject><subject>Kidney Diseases - genetics</subject><subject>Kidney Diseases - metabolism</subject><subject>Kidney Diseases - pathology</subject><subject>Kidney Neoplasms - genetics</subject><subject>Kidney Neoplasms - metabolism</subject><subject>Medical sciences</subject><subject>microRNAs</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Models, Biological</subject><subject>Nephrology. Urinary tract diseases</subject><subject>nephron</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Polycystic Kidney Diseases - genetics</subject><subject>Polycystic Kidney Diseases - metabolism</subject><subject>renal disease</subject><subject>Renal failure</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90F1LHDEUBuBQKrpar7yXoVAUZLb5mEySS5H6AYvC0l6HbHKGxp2ZaM5uwX_fLLu1IOLVIfDw5pyXkBNGp4wK_X0Zp5wyNm0a_YlMmOSiZkrKz2RCqZY1l0IfkEPER1reRtB9csA5F0o1ZkLEPPVQpa4aos9pfn-JVRyrZQwjvFS_0wAJVw4jVm4MVYgIDuEL2etcj3C8m0fk1_WPn1e39ezh5u7qclZ7ydWq7nhQLQVvuDFUu84IYRZdCN5pJqgXwnMJjew4LAoLAdpGaNCLVnnTtEyKI3K2zX3K6XkNuLJDRA9970ZIa7SGa8NoQ3WR5x9KVi7XotFKFPr1DX1M6zyWOzZ5lGnT8oIutqh0gpihs085Di6_lCS7Kd0uo92UbkvpRZ_uIteLAcKr_ddyAd92wKF3fZfd6CP-d7JVlKrNt3LroLT6J0K26COMHkLM4Fc2pPjuAn8B90uYsA</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Chandrasekaran, Karthikeyan</creator><creator>Karolina, Dwi S.</creator><creator>Sepramaniam, Sugunavathi</creator><creator>Armugam, Arunmozhiarasi</creator><creator>Marelyn Wintour, E.</creator><creator>Bertram, John F.</creator><creator>Jeyaseelan, Kandiah</creator><general>Elsevier Inc</general><general>Nature Publishing Group</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20120401</creationdate><title>Role of microRNAs in kidney homeostasis and disease</title><author>Chandrasekaran, Karthikeyan ; Karolina, Dwi S. ; Sepramaniam, Sugunavathi ; Armugam, Arunmozhiarasi ; Marelyn Wintour, E. ; Bertram, John F. ; Jeyaseelan, Kandiah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-f2d760ec929908af9339bfddca8130c33c25e45f2eb60edde6438e8b67c946153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>aquaporin</topic><topic>Biological and medical sciences</topic><topic>blood pressure regulation</topic><topic>Diabetic Nephropathies - genetics</topic><topic>Diabetic Nephropathies - metabolism</topic><topic>Fibrosis</topic><topic>Gene Expression Profiling</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hypertension, Renal - genetics</topic><topic>Hypertension, Renal - metabolism</topic><topic>ion channel</topic><topic>Kidney - growth & development</topic><topic>Kidney - metabolism</topic><topic>Kidney Diseases - genetics</topic><topic>Kidney Diseases - metabolism</topic><topic>Kidney Diseases - pathology</topic><topic>Kidney Neoplasms - genetics</topic><topic>Kidney Neoplasms - metabolism</topic><topic>Medical sciences</topic><topic>microRNAs</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Models, Biological</topic><topic>Nephrology. Urinary tract diseases</topic><topic>nephron</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Polycystic Kidney Diseases - genetics</topic><topic>Polycystic Kidney Diseases - metabolism</topic><topic>renal disease</topic><topic>Renal failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chandrasekaran, Karthikeyan</creatorcontrib><creatorcontrib>Karolina, Dwi S.</creatorcontrib><creatorcontrib>Sepramaniam, Sugunavathi</creatorcontrib><creatorcontrib>Armugam, Arunmozhiarasi</creatorcontrib><creatorcontrib>Marelyn Wintour, E.</creatorcontrib><creatorcontrib>Bertram, John F.</creatorcontrib><creatorcontrib>Jeyaseelan, Kandiah</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chandrasekaran, Karthikeyan</au><au>Karolina, Dwi S.</au><au>Sepramaniam, Sugunavathi</au><au>Armugam, Arunmozhiarasi</au><au>Marelyn Wintour, E.</au><au>Bertram, John F.</au><au>Jeyaseelan, Kandiah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of microRNAs in kidney homeostasis and disease</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>81</volume><issue>7</issue><spage>617</spage><epage>627</epage><pages>617-627</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><coden>KDYIA5</coden><abstract>MicroRNAs (miRNAs) are endogenous short (20–22 nucleotides) non-coding RNA molecules that mediate gene expression. This is an important regulatory mechanism to modulate fundamental cellular processes such as differentiation, proliferation, death, metabolism, and pathophysiology of many diseases. The miRNA expression profile of the kidney differs greatly from that of other organs, as well as between the different regions in the kidney. In kidneys, miRNAs are indispensable for development and homeostasis. In this review, we explore the involvement of miRNAs in the regulation of blood pressure, hormone, water, and ion balance pertaining to kidney homeostasis. We also highlight their importance in renal pathophysiology, such as in polycystic disease, diabetic nephropathy, nephrogenic diabetes insipidus, hypertension, renal cancer, and kidney fibrosis (epithelial–mesenchymal transition). In addition, we highlight the need for further investigations on miRNA-based studies in the development of diagnostic, prognostic, and therapeutic tools for renal diseases.</abstract><cop>Basingstoke</cop><pub>Elsevier Inc</pub><pmid>22237749</pmid><doi>10.1038/ki.2011.448</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals aquaporin Biological and medical sciences blood pressure regulation Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Fibrosis Gene Expression Profiling Homeostasis Humans Hypertension, Renal - genetics Hypertension, Renal - metabolism ion channel Kidney - growth & development Kidney - metabolism Kidney Diseases - genetics Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Medical sciences microRNAs MicroRNAs - genetics MicroRNAs - metabolism Models, Biological Nephrology. Urinary tract diseases nephron Nephropathies. Renovascular diseases. Renal failure Polycystic Kidney Diseases - genetics Polycystic Kidney Diseases - metabolism renal disease Renal failure |
| title | Role of microRNAs in kidney homeostasis and disease |
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