Comparative developmental biology of the uterus: Insights into mechanisms and developmental disruption
► This review summarizes developmental biology of the Müllerian duct and uterus. ► Disruption of uterine development can cause infertility and cancer. ► Endocrine disruptor compounds elicit effects via developmental programming. ► Comparative biology is useful to understand congenital abnormalities...
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| Veröffentlicht in: | Molecular and cellular endocrinology 2012-05, Vol.354 (1-2), p.34-53 |
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| container_title | Molecular and cellular endocrinology |
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| creator | Spencer, Thomas E. Dunlap, Kathrin A. Filant, Justyna |
| description | ► This review summarizes developmental biology of the Müllerian duct and uterus. ► Disruption of uterine development can cause infertility and cancer. ► Endocrine disruptor compounds elicit effects via developmental programming. ► Comparative biology is useful to understand congenital abnormalities in humans.
The uterus is an essential organ for reproduction in mammals that derives from the Müllerian duct. Despite the importance of the uterus for the fertility and health of women and their offspring, relatively little is known about the hormonal, cellular and molecular mechanisms that regulate development of the Müllerian duct and uterus. This review aims to summarize the hormonal, cellular and molecular mechanisms and pathways governing development of the Müllerian duct and uterus as well as highlight developmental programming effects of endocrine disruptor compounds. Organogenesis, morphogenesis, and functional differentiation of the uterus are complex, multifactorial processes. Disruption of uterine development in the fetus and neonate by genetic defects and exposure to endocrine disruptor compounds can cause infertility and cancer in the adult and their offspring via developmental programming. Clear conservation of some factors and pathways are observed between species; therefore, comparative biology is useful to identify candidate genes and pathways underlying congenital abnormalities in humans. |
| doi_str_mv | 10.1016/j.mce.2011.09.035 |
| format | Article |
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The uterus is an essential organ for reproduction in mammals that derives from the Müllerian duct. Despite the importance of the uterus for the fertility and health of women and their offspring, relatively little is known about the hormonal, cellular and molecular mechanisms that regulate development of the Müllerian duct and uterus. This review aims to summarize the hormonal, cellular and molecular mechanisms and pathways governing development of the Müllerian duct and uterus as well as highlight developmental programming effects of endocrine disruptor compounds. Organogenesis, morphogenesis, and functional differentiation of the uterus are complex, multifactorial processes. Disruption of uterine development in the fetus and neonate by genetic defects and exposure to endocrine disruptor compounds can cause infertility and cancer in the adult and their offspring via developmental programming. Clear conservation of some factors and pathways are observed between species; therefore, comparative biology is useful to identify candidate genes and pathways underlying congenital abnormalities in humans.</description><identifier>ISSN: 0303-7207</identifier><identifier>EISSN: 1872-8057</identifier><identifier>DOI: 10.1016/j.mce.2011.09.035</identifier><identifier>PMID: 22008458</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>adults ; Animals ; Cell Differentiation ; Cellular ; Colostrum - chemistry ; Colostrum - physiology ; congenital abnormalities ; Development ; Developmental Biology ; Disruption ; Ducts ; Endocrine disruptors ; Endocrine Disruptors - toxicity ; Environmental Pollutants - toxicity ; Female ; fetal development ; Gene Expression Regulation, Developmental ; genes ; genetic disorders ; Humans ; Morphogenesis ; Mullerian Ducts - embryology ; neonates ; organogenesis ; Pathways ; Pregnancy ; progeny ; Programming ; Reproduction ; Reproductive tract ; Uterus ; Uterus - cytology ; Uterus - embryology ; Uterus - growth & development ; women's health</subject><ispartof>Molecular and cellular endocrinology, 2012-05, Vol.354 (1-2), p.34-53</ispartof><rights>2011 Elsevier Ireland Ltd</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-7cf6323bd042eb1e21e99db55b8ebaac5c9477b074724861e3bccfb3a1d638013</citedby><cites>FETCH-LOGICAL-c409t-7cf6323bd042eb1e21e99db55b8ebaac5c9477b074724861e3bccfb3a1d638013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mce.2011.09.035$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22008458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spencer, Thomas E.</creatorcontrib><creatorcontrib>Dunlap, Kathrin A.</creatorcontrib><creatorcontrib>Filant, Justyna</creatorcontrib><title>Comparative developmental biology of the uterus: Insights into mechanisms and developmental disruption</title><title>Molecular and cellular endocrinology</title><addtitle>Mol Cell Endocrinol</addtitle><description>► This review summarizes developmental biology of the Müllerian duct and uterus. ► Disruption of uterine development can cause infertility and cancer. ► Endocrine disruptor compounds elicit effects via developmental programming. ► Comparative biology is useful to understand congenital abnormalities in humans.
The uterus is an essential organ for reproduction in mammals that derives from the Müllerian duct. Despite the importance of the uterus for the fertility and health of women and their offspring, relatively little is known about the hormonal, cellular and molecular mechanisms that regulate development of the Müllerian duct and uterus. This review aims to summarize the hormonal, cellular and molecular mechanisms and pathways governing development of the Müllerian duct and uterus as well as highlight developmental programming effects of endocrine disruptor compounds. Organogenesis, morphogenesis, and functional differentiation of the uterus are complex, multifactorial processes. Disruption of uterine development in the fetus and neonate by genetic defects and exposure to endocrine disruptor compounds can cause infertility and cancer in the adult and their offspring via developmental programming. Clear conservation of some factors and pathways are observed between species; therefore, comparative biology is useful to identify candidate genes and pathways underlying congenital abnormalities in humans.</description><subject>adults</subject><subject>Animals</subject><subject>Cell Differentiation</subject><subject>Cellular</subject><subject>Colostrum - chemistry</subject><subject>Colostrum - physiology</subject><subject>congenital abnormalities</subject><subject>Development</subject><subject>Developmental Biology</subject><subject>Disruption</subject><subject>Ducts</subject><subject>Endocrine disruptors</subject><subject>Endocrine Disruptors - toxicity</subject><subject>Environmental Pollutants - toxicity</subject><subject>Female</subject><subject>fetal development</subject><subject>Gene Expression Regulation, Developmental</subject><subject>genes</subject><subject>genetic disorders</subject><subject>Humans</subject><subject>Morphogenesis</subject><subject>Mullerian Ducts - embryology</subject><subject>neonates</subject><subject>organogenesis</subject><subject>Pathways</subject><subject>Pregnancy</subject><subject>progeny</subject><subject>Programming</subject><subject>Reproduction</subject><subject>Reproductive tract</subject><subject>Uterus</subject><subject>Uterus - cytology</subject><subject>Uterus - embryology</subject><subject>Uterus - growth & development</subject><subject>women's health</subject><issn>0303-7207</issn><issn>1872-8057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kT2P1DAQhi0E4paDH0AD6aBJGDsftqFCKz5OOokCrrb8Mdn1KomD7ax0_56sclBQXDXNM49m3peQ1xQqCrT7cKpGixUDSiuQFdTtE7KjgrNSQMufkh3UUJecAb8iL1I6AQBvmXhOrhgDEE0rdqTfh3HWUWd_xsLhGYcwjzhlPRTGhyEc7ovQF_mIxZIxLuljcTMlfzjmVPgph2JEe9STT2Mq9OT-Mzif4jJnH6aX5Fmvh4SvHuY1ufv65df-e3n749vN_vNtaRuQueS272pWGwcNQ0ORUZTSmbY1Ao3WtrWy4dwAbzhrREexNtb2ptbUdbUAWl-Td5t3juH3gimr0SeLw6AnDEtSkglJYU1qJd8_SlJgTAIF2a0o3VAbQ0oRezVHP-p4v0LqUoQ6qbUIdSlCgVSb_s2DfjEjun8bf5Nfgbcb0Oug9CH6pO5-roYWgAqQ4vLLp43ANbCzx6iS9ThZdD6izcoF_8gBfwBjoKOO</recordid><startdate>20120506</startdate><enddate>20120506</enddate><creator>Spencer, Thomas E.</creator><creator>Dunlap, Kathrin A.</creator><creator>Filant, Justyna</creator><general>Elsevier Ireland Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20120506</creationdate><title>Comparative developmental biology of the uterus: Insights into mechanisms and developmental disruption</title><author>Spencer, Thomas E. ; Dunlap, Kathrin A. ; Filant, Justyna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-7cf6323bd042eb1e21e99db55b8ebaac5c9477b074724861e3bccfb3a1d638013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>adults</topic><topic>Animals</topic><topic>Cell Differentiation</topic><topic>Cellular</topic><topic>Colostrum - chemistry</topic><topic>Colostrum - physiology</topic><topic>congenital abnormalities</topic><topic>Development</topic><topic>Developmental Biology</topic><topic>Disruption</topic><topic>Ducts</topic><topic>Endocrine disruptors</topic><topic>Endocrine Disruptors - toxicity</topic><topic>Environmental Pollutants - toxicity</topic><topic>Female</topic><topic>fetal development</topic><topic>Gene Expression Regulation, Developmental</topic><topic>genes</topic><topic>genetic disorders</topic><topic>Humans</topic><topic>Morphogenesis</topic><topic>Mullerian Ducts - embryology</topic><topic>neonates</topic><topic>organogenesis</topic><topic>Pathways</topic><topic>Pregnancy</topic><topic>progeny</topic><topic>Programming</topic><topic>Reproduction</topic><topic>Reproductive tract</topic><topic>Uterus</topic><topic>Uterus - cytology</topic><topic>Uterus - embryology</topic><topic>Uterus - growth & development</topic><topic>women's health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spencer, Thomas E.</creatorcontrib><creatorcontrib>Dunlap, Kathrin A.</creatorcontrib><creatorcontrib>Filant, Justyna</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and cellular endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spencer, Thomas E.</au><au>Dunlap, Kathrin A.</au><au>Filant, Justyna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative developmental biology of the uterus: Insights into mechanisms and developmental disruption</atitle><jtitle>Molecular and cellular endocrinology</jtitle><addtitle>Mol Cell Endocrinol</addtitle><date>2012-05-06</date><risdate>2012</risdate><volume>354</volume><issue>1-2</issue><spage>34</spage><epage>53</epage><pages>34-53</pages><issn>0303-7207</issn><eissn>1872-8057</eissn><abstract>► This review summarizes developmental biology of the Müllerian duct and uterus. ► Disruption of uterine development can cause infertility and cancer. ► Endocrine disruptor compounds elicit effects via developmental programming. ► Comparative biology is useful to understand congenital abnormalities in humans.
The uterus is an essential organ for reproduction in mammals that derives from the Müllerian duct. Despite the importance of the uterus for the fertility and health of women and their offspring, relatively little is known about the hormonal, cellular and molecular mechanisms that regulate development of the Müllerian duct and uterus. This review aims to summarize the hormonal, cellular and molecular mechanisms and pathways governing development of the Müllerian duct and uterus as well as highlight developmental programming effects of endocrine disruptor compounds. Organogenesis, morphogenesis, and functional differentiation of the uterus are complex, multifactorial processes. Disruption of uterine development in the fetus and neonate by genetic defects and exposure to endocrine disruptor compounds can cause infertility and cancer in the adult and their offspring via developmental programming. Clear conservation of some factors and pathways are observed between species; therefore, comparative biology is useful to identify candidate genes and pathways underlying congenital abnormalities in humans.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>22008458</pmid><doi>10.1016/j.mce.2011.09.035</doi><tpages>20</tpages></addata></record> |
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| subjects | adults Animals Cell Differentiation Cellular Colostrum - chemistry Colostrum - physiology congenital abnormalities Development Developmental Biology Disruption Ducts Endocrine disruptors Endocrine Disruptors - toxicity Environmental Pollutants - toxicity Female fetal development Gene Expression Regulation, Developmental genes genetic disorders Humans Morphogenesis Mullerian Ducts - embryology neonates organogenesis Pathways Pregnancy progeny Programming Reproduction Reproductive tract Uterus Uterus - cytology Uterus - embryology Uterus - growth & development women's health |
| title | Comparative developmental biology of the uterus: Insights into mechanisms and developmental disruption |
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