Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels

Ifenprodil is a selective blocker of NMDA receptors that are heterodimers composed of GluN1/GluN2B subunits. This pharmacological profile has been extensively used to test the role of GluN2B-containing NMDA receptors in learning and memory formation. However, ifenprodil has also been reported to hav...

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Veröffentlicht in:	Journal of neurophysiology 2012-03, Vol.107 (6), p.1571-1575
Hauptverfasser:	Delaney, Andrew J, Power, John M, Sah, Pankaj
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala - drug effects Amygdala - metabolism Animals Calcium Channel Blockers - pharmacology Calcium Channels, P-Type - metabolism Calcium Channels, Q-Type - metabolism Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Neurons - drug effects Neurons - metabolism Patch-Clamp Techniques Piperidines - pharmacology Rats Rats, Wistar Synaptic Transmission - drug effects Synaptic Transmission - physiology
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