Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels
Ifenprodil is a selective blocker of NMDA receptors that are heterodimers composed of GluN1/GluN2B subunits. This pharmacological profile has been extensively used to test the role of GluN2B-containing NMDA receptors in learning and memory formation. However, ifenprodil has also been reported to hav...
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| Veröffentlicht in: | Journal of neurophysiology 2012-03, Vol.107 (6), p.1571-1575 |
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| container_title | Journal of neurophysiology |
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| creator | Delaney, Andrew J Power, John M Sah, Pankaj |
| description | Ifenprodil is a selective blocker of NMDA receptors that are heterodimers composed of GluN1/GluN2B subunits. This pharmacological profile has been extensively used to test the role of GluN2B-containing NMDA receptors in learning and memory formation. However, ifenprodil has also been reported to have actions at a number of other receptors, including high voltage-activated calcium channels. Here we show that, in the basolateral amygdala, ifenprodil dose dependently blocks excitatory transmission to principal neurons by a presynaptic mechanism. This action of ifenprodil has an IC(50) of ~10 μM and is fully occluded by the P/Q type calcium channel blocker ω-agatoxin. We conclude that ifenprodil reduces synaptic transmission in the basolateral amygdala by partially blocking P-type voltage-dependent calcium channels. |
| doi_str_mv | 10.1152/jn.01066.2011 |
| format | Article |
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| ispartof | Journal of neurophysiology, 2012-03, Vol.107 (6), p.1571-1575 |
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| language | eng |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Amygdala - drug effects Amygdala - metabolism Animals Calcium Channel Blockers - pharmacology Calcium Channels, P-Type - metabolism Calcium Channels, Q-Type - metabolism Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Neurons - drug effects Neurons - metabolism Patch-Clamp Techniques Piperidines - pharmacology Rats Rats, Wistar Synaptic Transmission - drug effects Synaptic Transmission - physiology |
| title | Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels |
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