Epithelial-mesenchymal interaction during UVB-induced up-regulation of neutral endopeptidase

We recently reported that overexpression of the elastase NEP (neutral endopeptidase) by fibroblasts plays a pivotal role in the mechanism of UVB-induced skin wrinkling by degrading dermal elastic fibres. Since UVB does not penetrate to the dermis, we hypothesized that factors secreted by UVB-exposed...

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Veröffentlicht in:	Biochemical journal 2012-04, Vol.443 (1), p.297-305
Hauptverfasser:	Nakajima, Hiroaki, Ezaki, Yoshiyuki, Nagai, Tomoyashu, Yoshioka, Ryosuke, Imokawa, Genji
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Coculture Techniques Cytokines - pharmacology Cytokines - physiology Epidermis - cytology Fibroblasts - enzymology Foreskin - cytology Gene Expression Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Granulocyte-Macrophage Colony-Stimulating Factor - physiology Granulocyte-Macrophage Colony-Stimulating Factor - secretion Humans Interleukin-1alpha - pharmacology Interleukin-1alpha - physiology Interleukin-1alpha - secretion Keratinocytes - radiation effects Keratinocytes - secretion Male Neprilysin - genetics Neprilysin - metabolism Paracrine Communication Ultraviolet Rays Up-Regulation - radiation effects
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