Therapeutic effects of human amniotic epithelial cell transplantation on double-transgenic mice co-expressing APPswe and PS1ΔE9-deleted genes

Human amniotic epithelial cells (HAECs), which exhibit characteristics of embryonic and pluripotent stem cells, could be utilized for cell therapy without legal or ethical problems. Double-transgenic (TG) mice ( n =20) and wild-type (WT) mice ( n =20) were randomly assigned to two groups, respective...

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Veröffentlicht in:	Science China. Life sciences 2012-02, Vol.55 (2), p.132-140
Hauptverfasser:	Xue, ShouRu, Chen, ChongFang, Dong, WanLi, Hui, GuoZhen, Liu, TianJun, Guo, LiHe
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Alzheimer Disease - genetics Alzheimer Disease - physiopathology Alzheimer Disease - surgery Amnion - cytology Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals Biomedical and Life Sciences Cell Transplantation - methods Cells, Cultured Cholinergic Neurons - metabolism Cholinergic Neurons - pathology Disease Models, Animal Epithelial Cells - cytology Epithelial Cells - metabolism Epithelial Cells - transplantation Female Gene Deletion Graft Survival - genetics Hippocampus - metabolism Hippocampus - pathology Homeodomain Proteins - metabolism Humans Immunohistochemistry Life Sciences Male Maze Learning - physiology Mice Mice, Inbred C57BL Mice, Transgenic Nanog Homeobox Protein Octamer Transcription Factor-3 - metabolism Presenilin-1 - genetics Presenilin-1 - metabolism Research Paper Time Factors Transplantation, Heterologous
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