Intraportal administration of DPP-IV inhibitor regulates insulin secretion and food intake mediated by the hepatic vagal afferent nerve in rats

J. Neurochem. (2012) 121, 66–76. Glucagon‐like peptide‐1 (GLP‐1) stimulates insulin secretion and suppresses food intake. Recent studies indicate that the hepatic vagal afferent nerve is involved in this response. Dipeptidyl peptidase‐IV (DPP‐IV) inhibitor extends the half‐life of endogenous GLP‐1 b...

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Veröffentlicht in:	Journal of neurochemistry 2012-04, Vol.121 (1), p.66-76
Hauptverfasser:	Fujiwara, Kansuke, Gotoh, Koro, Chiba, Seiichi, Masaki, Takayuki, Katsuragi, Isao, Kakuma, Tetsuya, Yoshimatsu, Hironobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain c-Fos protein Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dipeptidyl-Peptidase IV Inhibitors - administration & dosage Eating - drug effects Eating - physiology Feeding behavior Food intake Fundamental and applied biological sciences. Psychology Glucagon-like peptide 1 Glucose metabolism Histamine Hypothalamus Immunohistochemistry Infusions, Intravenous Inhibitor drugs Insulin Insulin - metabolism Insulin Secretion Liver Liver - drug effects Liver - innervation Liver - metabolism Male Medical sciences Neurochemistry Neurology Neurons Neurons, Afferent - drug effects Neurons, Afferent - metabolism Peritoneum Portal vein Portal Vein - drug effects Portal Vein - metabolism Rats Rats, Sprague-Dawley Rodents Sensory neurons vagal afferent nerve vagotomy Vagotomy - methods Vagus nerve Vagus Nerve - drug effects Vagus Nerve - metabolism Vertebrates: nervous system and sense organs
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