Correlation of atherosclerosis between different topographic sites is highly dependent on the type of hyperlipidemia
There is a surprising paucity of studies that provide quantitative correlative data on the extent of atherosclerosis between different topographic sites. The impact of cardiovascular risk factors is dependent on the vascular bed, which underlies site-selective effects on progression of atheroscleros...
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| Veröffentlicht in: | Heart and vessels 2012-03, Vol.27 (2), p.231-234 |
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| description | There is a surprising paucity of studies that provide quantitative correlative data on the extent of atherosclerosis between different topographic sites. The impact of cardiovascular risk factors is dependent on the vascular bed, which underlies site-selective effects on progression of atherosclerosis. Therefore, the intraindividual correlation of atherosclerosis between different topographic sites may be dependent on the specific cardiovascular risk profile. The focused objective of the current study is to evaluate whether the correlation of the extent of atherosclerosis between different topographic sites is dependent on the type of hyperlipidemia. Atherosclerosis was quantified at four different topographic locations in the aorta of rabbits with type II or type III hyperlipidemia. Correlation coefficients and semi-partial correlation coefficients adjusted for plasma lipoproteins and sex were determined to compare the degree of atherosclerosis at different topographic sites. Semi-partial correlations adjusted for total plasma cholesterol, plasma triglycerides, and sex of the intima/media ratio between different topographic sites were highly dependent on the type of hyperlipidemia. E.g., the semi-partial correlation coefficient between the intima/media ratio at the level of the ascending aorta and at the level of the descending thoracic aorta was 0.87 (
p
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| doi_str_mv | 10.1007/s00380-010-0098-9 |
| format | Article |
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p
< 0.0001) in the model of type II hyperlipidemia and was only 0.10 (
p
= NS) in the model of type III hyperlipidemia. This divergent pattern was also observed for other intersite correlations. Semi-partial Pearson correlation coefficients were very similar to unadjusted Pearson correlation coefficients. Correlation of atherosclerosis between different topographic sites may vary importantly in relation to the type of hyperlipidemia.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/s00380-010-0098-9</identifier><identifier>PMID: 21267577</identifier><identifier>CODEN: HEVEEO</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Animals ; Aorta - pathology ; Aortic Diseases - blood ; Aortic Diseases - etiology ; Aortic Diseases - pathology ; Atherosclerosis ; Atherosclerosis - blood ; Atherosclerosis - etiology ; Atherosclerosis - pathology ; Biomedical Engineering and Bioengineering ; Cardiac Surgery ; Cardiology ; Cholesterol, Dietary ; Coronary vessels ; Correlation analysis ; Disease Models, Animal ; Female ; Hyperlipoproteinemia Type II - blood ; Hyperlipoproteinemia Type II - complications ; Hyperlipoproteinemia Type II - etiology ; Hyperlipoproteinemia Type III - blood ; Hyperlipoproteinemia Type III - complications ; Hyperlipoproteinemia Type III - etiology ; Lipids ; Lipids - blood ; Male ; Medicine ; Medicine & Public Health ; Rabbits ; Receptors, LDL - deficiency ; Receptors, LDL - genetics ; Risk factors ; Severity of Illness Index ; Short Communication ; Tunica Intima - pathology ; Tunica Media - pathology ; Vascular Surgery</subject><ispartof>Heart and vessels, 2012-03, Vol.27 (2), p.231-234</ispartof><rights>Springer 2011</rights><rights>Springer 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-987a7107e4752d997520245adf440e6fdb2aaa8056d552d6f2be4acb9229c8c3</citedby><cites>FETCH-LOGICAL-c394t-987a7107e4752d997520245adf440e6fdb2aaa8056d552d6f2be4acb9229c8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00380-010-0098-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00380-010-0098-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21267577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Craeyveld, Eline</creatorcontrib><creatorcontrib>Gordts, Stephanie C.</creatorcontrib><creatorcontrib>Jacobs, Frank</creatorcontrib><creatorcontrib>De Geest, Bart</creatorcontrib><title>Correlation of atherosclerosis between different topographic sites is highly dependent on the type of hyperlipidemia</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><addtitle>Heart Vessels</addtitle><description>There is a surprising paucity of studies that provide quantitative correlative data on the extent of atherosclerosis between different topographic sites. The impact of cardiovascular risk factors is dependent on the vascular bed, which underlies site-selective effects on progression of atherosclerosis. Therefore, the intraindividual correlation of atherosclerosis between different topographic sites may be dependent on the specific cardiovascular risk profile. The focused objective of the current study is to evaluate whether the correlation of the extent of atherosclerosis between different topographic sites is dependent on the type of hyperlipidemia. Atherosclerosis was quantified at four different topographic locations in the aorta of rabbits with type II or type III hyperlipidemia. Correlation coefficients and semi-partial correlation coefficients adjusted for plasma lipoproteins and sex were determined to compare the degree of atherosclerosis at different topographic sites. Semi-partial correlations adjusted for total plasma cholesterol, plasma triglycerides, and sex of the intima/media ratio between different topographic sites were highly dependent on the type of hyperlipidemia. E.g., the semi-partial correlation coefficient between the intima/media ratio at the level of the ascending aorta and at the level of the descending thoracic aorta was 0.87 (
p
< 0.0001) in the model of type II hyperlipidemia and was only 0.10 (
p
= NS) in the model of type III hyperlipidemia. This divergent pattern was also observed for other intersite correlations. Semi-partial Pearson correlation coefficients were very similar to unadjusted Pearson correlation coefficients. Correlation of atherosclerosis between different topographic sites may vary importantly in relation to the type of hyperlipidemia.</description><subject>Animals</subject><subject>Aorta - pathology</subject><subject>Aortic Diseases - blood</subject><subject>Aortic Diseases - etiology</subject><subject>Aortic Diseases - pathology</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - blood</subject><subject>Atherosclerosis - etiology</subject><subject>Atherosclerosis - pathology</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Cholesterol, Dietary</subject><subject>Coronary vessels</subject><subject>Correlation analysis</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Hyperlipoproteinemia Type II - blood</subject><subject>Hyperlipoproteinemia Type II - complications</subject><subject>Hyperlipoproteinemia Type II - etiology</subject><subject>Hyperlipoproteinemia Type III - blood</subject><subject>Hyperlipoproteinemia Type III - complications</subject><subject>Hyperlipoproteinemia Type III - etiology</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Rabbits</subject><subject>Receptors, LDL - deficiency</subject><subject>Receptors, LDL - genetics</subject><subject>Risk factors</subject><subject>Severity of Illness Index</subject><subject>Short Communication</subject><subject>Tunica Intima - pathology</subject><subject>Tunica Media - pathology</subject><subject>Vascular Surgery</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kU2LFDEQhoO4uOPqD_Aiwcue2q2kP5IcZdBVWPCy95DuVE9n6em0SQaZf281syoIHlJ1qKeehLyMvRPwUQCouwxQa6hA0AGjK_OC7UQn2kq2qn7JdmBoomuprtnrnJ8ARGuEecWupZCdapXasbKPKeHsSogLjyN3ZcIU8zBvNWTeY_mJuHAfxhETLoWXuMZDcusUBp5DwcwJm8Jhms_c44qL3yiykYmX84qbdqKe5rAGj8fg3rCr0c0Z3z73G_b45fPj_mv18P3-2_7TQzXUpimV0copAQob1UpvDFWQTev82DSA3eh76ZzT0Ha-JaAbZY-NG3ojpRn0UN-w24t2TfHHCXOxx5AHnGe3YDxla6SuFRjVEPnhH_IpntJCbyNI6UYr3REkLtBAX5MTjnZN4ejS2QqwWx72koelPOyWhzW08_5ZfOqP6P9s_A6AAHkBMo2WA6a_N__f-gvMupeM</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Van Craeyveld, Eline</creator><creator>Gordts, Stephanie C.</creator><creator>Jacobs, Frank</creator><creator>De Geest, Bart</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Correlation of atherosclerosis between different topographic sites is highly dependent on the type of hyperlipidemia</title><author>Van Craeyveld, Eline ; Gordts, Stephanie C. ; Jacobs, Frank ; De Geest, Bart</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-987a7107e4752d997520245adf440e6fdb2aaa8056d552d6f2be4acb9229c8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Aorta - pathology</topic><topic>Aortic Diseases - blood</topic><topic>Aortic Diseases - etiology</topic><topic>Aortic Diseases - pathology</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - blood</topic><topic>Atherosclerosis - etiology</topic><topic>Atherosclerosis - pathology</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Cholesterol, Dietary</topic><topic>Coronary vessels</topic><topic>Correlation analysis</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Hyperlipoproteinemia Type II - blood</topic><topic>Hyperlipoproteinemia Type II - complications</topic><topic>Hyperlipoproteinemia Type II - etiology</topic><topic>Hyperlipoproteinemia Type III - blood</topic><topic>Hyperlipoproteinemia Type III - complications</topic><topic>Hyperlipoproteinemia Type III - etiology</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Rabbits</topic><topic>Receptors, LDL - deficiency</topic><topic>Receptors, LDL - genetics</topic><topic>Risk factors</topic><topic>Severity of Illness Index</topic><topic>Short Communication</topic><topic>Tunica Intima - pathology</topic><topic>Tunica Media - pathology</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Craeyveld, Eline</creatorcontrib><creatorcontrib>Gordts, Stephanie C.</creatorcontrib><creatorcontrib>Jacobs, Frank</creatorcontrib><creatorcontrib>De Geest, Bart</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Craeyveld, Eline</au><au>Gordts, Stephanie C.</au><au>Jacobs, Frank</au><au>De Geest, Bart</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of atherosclerosis between different topographic sites is highly dependent on the type of hyperlipidemia</atitle><jtitle>Heart and vessels</jtitle><stitle>Heart Vessels</stitle><addtitle>Heart Vessels</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>27</volume><issue>2</issue><spage>231</spage><epage>234</epage><pages>231-234</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><coden>HEVEEO</coden><abstract>There is a surprising paucity of studies that provide quantitative correlative data on the extent of atherosclerosis between different topographic sites. The impact of cardiovascular risk factors is dependent on the vascular bed, which underlies site-selective effects on progression of atherosclerosis. Therefore, the intraindividual correlation of atherosclerosis between different topographic sites may be dependent on the specific cardiovascular risk profile. The focused objective of the current study is to evaluate whether the correlation of the extent of atherosclerosis between different topographic sites is dependent on the type of hyperlipidemia. Atherosclerosis was quantified at four different topographic locations in the aorta of rabbits with type II or type III hyperlipidemia. Correlation coefficients and semi-partial correlation coefficients adjusted for plasma lipoproteins and sex were determined to compare the degree of atherosclerosis at different topographic sites. Semi-partial correlations adjusted for total plasma cholesterol, plasma triglycerides, and sex of the intima/media ratio between different topographic sites were highly dependent on the type of hyperlipidemia. E.g., the semi-partial correlation coefficient between the intima/media ratio at the level of the ascending aorta and at the level of the descending thoracic aorta was 0.87 (
p
< 0.0001) in the model of type II hyperlipidemia and was only 0.10 (
p
= NS) in the model of type III hyperlipidemia. This divergent pattern was also observed for other intersite correlations. Semi-partial Pearson correlation coefficients were very similar to unadjusted Pearson correlation coefficients. Correlation of atherosclerosis between different topographic sites may vary importantly in relation to the type of hyperlipidemia.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>21267577</pmid><doi>10.1007/s00380-010-0098-9</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Aorta - pathology Aortic Diseases - blood Aortic Diseases - etiology Aortic Diseases - pathology Atherosclerosis Atherosclerosis - blood Atherosclerosis - etiology Atherosclerosis - pathology Biomedical Engineering and Bioengineering Cardiac Surgery Cardiology Cholesterol, Dietary Coronary vessels Correlation analysis Disease Models, Animal Female Hyperlipoproteinemia Type II - blood Hyperlipoproteinemia Type II - complications Hyperlipoproteinemia Type II - etiology Hyperlipoproteinemia Type III - blood Hyperlipoproteinemia Type III - complications Hyperlipoproteinemia Type III - etiology Lipids Lipids - blood Male Medicine Medicine & Public Health Rabbits Receptors, LDL - deficiency Receptors, LDL - genetics Risk factors Severity of Illness Index Short Communication Tunica Intima - pathology Tunica Media - pathology Vascular Surgery |
| title | Correlation of atherosclerosis between different topographic sites is highly dependent on the type of hyperlipidemia |
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