Synthesis of D-ring-substituted (5′R)- and (5′S)-17β-pyrazolinylandrostene epimers and comparison of their potential anticancer activities

► Steroidal 17β-pyrazolines were prepared from 21-benzalpregnenolone derivatives. ► The reaction afforded a mixture of 5′R and 5′S pyrazolinylandrostene epimers. ► The structures of epimers were determinated by NMR analysis. ► The two epimeric series possess different antiproliferative activity. Var...

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