Replication of genome-wide association signals of type 2 diabetes in Han Chinese in a prospective cohort

Summary Background A recent genome‐wide association study for type 2 diabetes in Han Chinese identified several novel genetic variants. We investigated their associations with quantitative measures to explore the mechanism by which these variants influence glucose homoeostasis. We also examined whe...

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Veröffentlicht in:	Clinical endocrinology (Oxford) 2012-03, Vol.76 (3), p.365-372
Hauptverfasser:	Chang, Yi-Cheng, Chiu, Yen-Feng, Liu, Pi-Hua, Shih, Kuang-Chung, Lin, Ming-Wei, Sheu, Wayne H.-H., Quertermous, Thomas, Curb, Jess David, Hsiung, Chano A., Lee, Wei-Jei, Lee, Po-Chu, Chen, Yuan-Tsong, Chuang, Lee-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Adult Asian Continental Ancestry Group - genetics Biological and medical sciences Blood Glucose - metabolism China Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Fundamental and applied biological sciences. Psychology Gene Expression Gene Frequency Genetic Predisposition to Disease - genetics Genome-Wide Association Study - methods Genotype Humans Insulin - blood Insulin Resistance - genetics KCNQ1 Potassium Channel - genetics Male Medical sciences Middle Aged Miscellaneous Oxidoreductases - genetics Polymorphism, Single Nucleotide Prospective Studies Proto-Oncogene Proteins c-maf - genetics Public health. Hygiene Public health. Hygiene-occupational medicine Racemases and Epimerases - genetics Receptor-Like Protein Tyrosine Phosphatases, Class 2 - genetics Reverse Transcriptase Polymerase Chain Reaction Tumor Suppressor Proteins - genetics Vertebrates: endocrinology WW Domain-Containing Oxidoreductase
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