Low serum PON1 activity: An independent risk factor for coronary artery disease in North–West Indian type 2 diabetics

The paraoxonase (PON1) gene polymorphisms are known to affect the PON1 activity and coronary artery disease (CAD) risk. Studies done so far have given conflicting results. In the present study, we determined the role of PON1 genetic variants and PON1 activity in the development of CAD in North–West...

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Veröffentlicht in:	Gene 2012-04, Vol.498 (1), p.13-19
Hauptverfasser:	Gupta, Nidhi, Binu, K.B.K., Singh, Surjit, Maturu, Nagarjuna V., Sharma, Yash P., Bhansali, Anil, Gill, Kiran Dip
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aryldialkylphosphatase - blood Aryldialkylphosphatase - deficiency Aryldialkylphosphatase - genetics blood serum Case-Control Studies computer software Coronary artery disease Coronary Artery Disease - enzymology Coronary Artery Disease - etiology Coronary Artery Disease - genetics Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - enzymology Diabetes Mellitus, Type 2 - genetics Diabetic Angiopathies - enzymology Diabetic Angiopathies - etiology Diabetic Angiopathies - genetics Ethnic Groups Female genes genotyping Haplotypes Humans India Logistic Models Male Middle Aged nationalities and ethnic groups noninsulin-dependent diabetes mellitus Paraoxonase1 Polymorphism, Single Nucleotide Polymorphisms Promoter Regions, Genetic regression analysis risk Risk Factors Type 2 diabetes
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