New insights into the biology of molecular subtypes of diffuse large B-cell lymphoma and Burkitt lymphoma

Diffuse large B-cell lymphoma and Burkitt lymphoma are two distinct lymphoma entities recognized by the current World Health Organization classification of lymphoid neoplasms. Although diagnostic criteria to distinguish these two subtypes have been established, a subset of cases have overlapping cha...

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Veröffentlicht in:Best practice & research. Clinical haematology 2012-03, Vol.25 (1), p.3-12
Hauptverfasser: Frick, Mareike, MD, Dörken, Bernd, MD, Lenz, Georg, MD
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container_title Best practice & research. Clinical haematology
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creator Frick, Mareike, MD
Dörken, Bernd, MD
Lenz, Georg, MD
description Diffuse large B-cell lymphoma and Burkitt lymphoma are two distinct lymphoma entities recognized by the current World Health Organization classification of lymphoid neoplasms. Although diagnostic criteria to distinguish these two subtypes have been established, a subset of cases have overlapping characteristics and therefore, the distinction can be challenging. Thus, the World Health Organization classification introduced an intermediate subtype referred as “B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma”. This review summarizes our current understanding of the biology of these lymphoma subtypes.
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subjects Antibodies, Monoclonal, Murine-Derived - administration & dosage
Antibodies, Monoclonal, Murine-Derived - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Burkitt lymphoma
Burkitt Lymphoma - classification
Burkitt Lymphoma - drug therapy
Burkitt Lymphoma - genetics
Burkitt Lymphoma - mortality
Cyclophosphamide - administration & dosage
Cyclophosphamide - therapeutic use
diffuse large B-cell lymphoma
Doxorubicin - administration & dosage
Doxorubicin - therapeutic use
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Hematology, Oncology and Palliative Medicine
Humans
Lymphoma, Large B-Cell, Diffuse - classification
Lymphoma, Large B-Cell, Diffuse - drug therapy
Lymphoma, Large B-Cell, Diffuse - genetics
Lymphoma, Large B-Cell, Diffuse - mortality
molecular pathogenesis
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Prednisone - administration & dosage
Prednisone - therapeutic use
Prognosis
Survival Analysis
Vincristine - administration & dosage
Vincristine - therapeutic use
title New insights into the biology of molecular subtypes of diffuse large B-cell lymphoma and Burkitt lymphoma
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