Thyroid-Associated Periorbitopathy: Eyebrow Fat and Soft Tissue Expansion in Patients With Thyroid-Associated Orbitopathy
OBJECTIVE To compare soft tissue and fat volumes in the supraorbital area of healthy patients and patients with thyroid-associated orbitopathy (TAO) using 3-dimensional reconstruction software. METHODS The superiolateral orbital area was delineated on a bony framework. Three-dimensional reconstructi...
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| Veröffentlicht in: | Archives of ophthalmology (1960) 2012-03, Vol.130 (3), p.319-328 |
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| creator | Papageorgiou, Konstantinos I Hwang, Catherine J Chang, Shu-Hong H Jarullazada, Imran Chokron Garneau, Helene Ang, Michael J King, Adam J Mancini, Ronald Douglas, Raymond S Goldberg, Robert A |
| description | OBJECTIVE To compare soft tissue and fat volumes in the supraorbital area of healthy patients and patients with thyroid-associated orbitopathy (TAO) using 3-dimensional reconstruction software. METHODS The superiolateral orbital area was delineated on a bony framework. Three-dimensional reconstruction and volumetric calculation of the retro-orbicularis oculi fat (brow fat), galeal fat (including the retro-orbicularis oculi fat), and soft-tissue muscle were performed. RESULTS We analyzed 100 computed tomographic scans from 48 patients with TAO and 52 control subjects. All patients showed an age-related increase of fat volumes. The mean total eyebrow volume was greater in patients with TAO vs healthy control subjects (P |
| doi_str_mv | 10.1001/archopthalmol.2011.1271 |
| format | Article |
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METHODS The superiolateral orbital area was delineated on a bony framework. Three-dimensional reconstruction and volumetric calculation of the retro-orbicularis oculi fat (brow fat), galeal fat (including the retro-orbicularis oculi fat), and soft-tissue muscle were performed. RESULTS We analyzed 100 computed tomographic scans from 48 patients with TAO and 52 control subjects. All patients showed an age-related increase of fat volumes. The mean total eyebrow volume was greater in patients with TAO vs healthy control subjects (P < .001). Galeal fat (P = .02) and retro-orbicularis oculi fat (P = .01) volumes were significantly higher in patients with TAO vs control subjects. Soft-tissue muscle volume decreased with age in healthy females but remained constant in the aging female group with TAO. Both total volume and brow thickness did not appear to change with age in healthy patients but exhibited an increase in the female population with TAO. CONCLUSIONS This study brings into focus the clinicopathologic entity of thyroid-associated periorbitopathy. Three-dimensional evaluation of computed tomographic scans can provide information on volumetric changes in the eyebrow profile of patients with TAO. Further investigation of the biologic and morphologic changes of eyebrow fat and soft tissue in patients with TAO may help better characterize, classify, and guide their treatment.</description><identifier>ISSN: 0003-9950</identifier><identifier>ISSN: 2168-6165</identifier><identifier>EISSN: 1538-3601</identifier><identifier>EISSN: 2168-6173</identifier><identifier>DOI: 10.1001/archopthalmol.2011.1271</identifier><identifier>PMID: 22411661</identifier><language>eng</language><publisher>Chicago, IL: American Medical Association</publisher><subject>Adipose Tissue - pathology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anatomic Landmarks - pathology ; Biological and medical sciences ; Eye diseases ; Eyebrows - pathology ; Eyes & eyesight ; Facial Muscles - pathology ; Female ; Graves Ophthalmopathy - complications ; Graves Ophthalmopathy - pathology ; Humans ; Imaging, Three-Dimensional - methods ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Ophthalmology ; Orbit diseases ; Orbital Diseases - etiology ; Orbital Diseases - pathology ; Patients ; Retrospective Studies ; Software ; Tissues ; Tomography ; Young Adult</subject><ispartof>Archives of ophthalmology (1960), 2012-03, Vol.130 (3), p.319-328</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Medical Association Mar 2012</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25790996$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22411661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Papageorgiou, Konstantinos I</creatorcontrib><creatorcontrib>Hwang, Catherine J</creatorcontrib><creatorcontrib>Chang, Shu-Hong H</creatorcontrib><creatorcontrib>Jarullazada, Imran</creatorcontrib><creatorcontrib>Chokron Garneau, Helene</creatorcontrib><creatorcontrib>Ang, Michael J</creatorcontrib><creatorcontrib>King, Adam J</creatorcontrib><creatorcontrib>Mancini, Ronald</creatorcontrib><creatorcontrib>Douglas, Raymond S</creatorcontrib><creatorcontrib>Goldberg, Robert A</creatorcontrib><title>Thyroid-Associated Periorbitopathy: Eyebrow Fat and Soft Tissue Expansion in Patients With Thyroid-Associated Orbitopathy</title><title>Archives of ophthalmology (1960)</title><addtitle>Arch Ophthalmol</addtitle><description>OBJECTIVE To compare soft tissue and fat volumes in the supraorbital area of healthy patients and patients with thyroid-associated orbitopathy (TAO) using 3-dimensional reconstruction software. METHODS The superiolateral orbital area was delineated on a bony framework. Three-dimensional reconstruction and volumetric calculation of the retro-orbicularis oculi fat (brow fat), galeal fat (including the retro-orbicularis oculi fat), and soft-tissue muscle were performed. RESULTS We analyzed 100 computed tomographic scans from 48 patients with TAO and 52 control subjects. All patients showed an age-related increase of fat volumes. The mean total eyebrow volume was greater in patients with TAO vs healthy control subjects (P < .001). Galeal fat (P = .02) and retro-orbicularis oculi fat (P = .01) volumes were significantly higher in patients with TAO vs control subjects. Soft-tissue muscle volume decreased with age in healthy females but remained constant in the aging female group with TAO. Both total volume and brow thickness did not appear to change with age in healthy patients but exhibited an increase in the female population with TAO. CONCLUSIONS This study brings into focus the clinicopathologic entity of thyroid-associated periorbitopathy. Three-dimensional evaluation of computed tomographic scans can provide information on volumetric changes in the eyebrow profile of patients with TAO. Further investigation of the biologic and morphologic changes of eyebrow fat and soft tissue in patients with TAO may help better characterize, classify, and guide their treatment.</description><subject>Adipose Tissue - pathology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anatomic Landmarks - pathology</subject><subject>Biological and medical sciences</subject><subject>Eye diseases</subject><subject>Eyebrows - pathology</subject><subject>Eyes & eyesight</subject><subject>Facial Muscles - pathology</subject><subject>Female</subject><subject>Graves Ophthalmopathy - complications</subject><subject>Graves Ophthalmopathy - pathology</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Ophthalmology</subject><subject>Orbit diseases</subject><subject>Orbital Diseases - etiology</subject><subject>Orbital Diseases - pathology</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Software</subject><subject>Tissues</subject><subject>Tomography</subject><subject>Young Adult</subject><issn>0003-9950</issn><issn>2168-6165</issn><issn>1538-3601</issn><issn>2168-6173</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0V2L1DAUBuAgijuu_gEvNAjiVcecJpM03i3LrAoLu7AjXpbTNqVZ2qYmKdp_b4YZHXbZqxB4zpuPl5D3wNbAGHxGX3duih32g-vXOQNYQ67gGVnBhhcZlwyekxVjjGdab9gZeRXCfdpKYPolOctzASAlrMiy6xbvbJNdhOBqi9E09NZ463xlo5swdssXul1M5d1veoWR4tjQO9dGurMhzIZu_0w4ButGakd6i9GaMQb608aOPhF9c4p9TV602Afz5riekx9X293lt-z65uv3y4vrDDkXMdtwJQs0teR5IRWvG8VEK5VmLROFgVYL2TbAOeSVkJohIFaNAq4qZhpjND8nnw65k3e_ZhNiOdhQm77H0bg5lDpXulDpl5L88Ejeu9mP6XIJFYIrAEhIHVDtXQjetOXk7YB-KYGV-27KB92U-27KfTdp8t0xfq4G0_yf-1dGAh-PAEONfetxrG04uU16tdYyubcHhwOeTgdRiFzyvyBHpQk</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Papageorgiou, Konstantinos I</creator><creator>Hwang, Catherine J</creator><creator>Chang, Shu-Hong H</creator><creator>Jarullazada, Imran</creator><creator>Chokron Garneau, Helene</creator><creator>Ang, Michael J</creator><creator>King, Adam J</creator><creator>Mancini, Ronald</creator><creator>Douglas, Raymond S</creator><creator>Goldberg, Robert A</creator><general>American Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Thyroid-Associated Periorbitopathy: Eyebrow Fat and Soft Tissue Expansion in Patients With Thyroid-Associated Orbitopathy</title><author>Papageorgiou, Konstantinos I ; Hwang, Catherine J ; Chang, Shu-Hong H ; Jarullazada, Imran ; Chokron Garneau, Helene ; Ang, Michael J ; King, Adam J ; Mancini, Ronald ; Douglas, Raymond S ; Goldberg, Robert A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a334t-53768aec6328673cd704f6790f048e1f946fd13312b4690a1aabd7137b0edee93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adipose Tissue - pathology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anatomic Landmarks - pathology</topic><topic>Biological and medical sciences</topic><topic>Eye diseases</topic><topic>Eyebrows - pathology</topic><topic>Eyes & eyesight</topic><topic>Facial Muscles - pathology</topic><topic>Female</topic><topic>Graves Ophthalmopathy - complications</topic><topic>Graves Ophthalmopathy - pathology</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Ophthalmology</topic><topic>Orbit diseases</topic><topic>Orbital Diseases - etiology</topic><topic>Orbital Diseases - pathology</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>Software</topic><topic>Tissues</topic><topic>Tomography</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Papageorgiou, Konstantinos I</creatorcontrib><creatorcontrib>Hwang, Catherine J</creatorcontrib><creatorcontrib>Chang, Shu-Hong H</creatorcontrib><creatorcontrib>Jarullazada, Imran</creatorcontrib><creatorcontrib>Chokron Garneau, Helene</creatorcontrib><creatorcontrib>Ang, Michael J</creatorcontrib><creatorcontrib>King, Adam J</creatorcontrib><creatorcontrib>Mancini, Ronald</creatorcontrib><creatorcontrib>Douglas, Raymond S</creatorcontrib><creatorcontrib>Goldberg, Robert A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of ophthalmology (1960)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Papageorgiou, Konstantinos I</au><au>Hwang, Catherine J</au><au>Chang, Shu-Hong H</au><au>Jarullazada, Imran</au><au>Chokron Garneau, Helene</au><au>Ang, Michael J</au><au>King, Adam J</au><au>Mancini, Ronald</au><au>Douglas, Raymond S</au><au>Goldberg, Robert A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thyroid-Associated Periorbitopathy: Eyebrow Fat and Soft Tissue Expansion in Patients With Thyroid-Associated Orbitopathy</atitle><jtitle>Archives of ophthalmology (1960)</jtitle><addtitle>Arch Ophthalmol</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>130</volume><issue>3</issue><spage>319</spage><epage>328</epage><pages>319-328</pages><issn>0003-9950</issn><issn>2168-6165</issn><eissn>1538-3601</eissn><eissn>2168-6173</eissn><abstract>OBJECTIVE To compare soft tissue and fat volumes in the supraorbital area of healthy patients and patients with thyroid-associated orbitopathy (TAO) using 3-dimensional reconstruction software. METHODS The superiolateral orbital area was delineated on a bony framework. Three-dimensional reconstruction and volumetric calculation of the retro-orbicularis oculi fat (brow fat), galeal fat (including the retro-orbicularis oculi fat), and soft-tissue muscle were performed. RESULTS We analyzed 100 computed tomographic scans from 48 patients with TAO and 52 control subjects. All patients showed an age-related increase of fat volumes. The mean total eyebrow volume was greater in patients with TAO vs healthy control subjects (P < .001). Galeal fat (P = .02) and retro-orbicularis oculi fat (P = .01) volumes were significantly higher in patients with TAO vs control subjects. Soft-tissue muscle volume decreased with age in healthy females but remained constant in the aging female group with TAO. Both total volume and brow thickness did not appear to change with age in healthy patients but exhibited an increase in the female population with TAO. CONCLUSIONS This study brings into focus the clinicopathologic entity of thyroid-associated periorbitopathy. Three-dimensional evaluation of computed tomographic scans can provide information on volumetric changes in the eyebrow profile of patients with TAO. Further investigation of the biologic and morphologic changes of eyebrow fat and soft tissue in patients with TAO may help better characterize, classify, and guide their treatment.</abstract><cop>Chicago, IL</cop><pub>American Medical Association</pub><pmid>22411661</pmid><doi>10.1001/archopthalmol.2011.1271</doi><tpages>10</tpages></addata></record> |
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| subjects | Adipose Tissue - pathology Adolescent Adult Aged Aged, 80 and over Anatomic Landmarks - pathology Biological and medical sciences Eye diseases Eyebrows - pathology Eyes & eyesight Facial Muscles - pathology Female Graves Ophthalmopathy - complications Graves Ophthalmopathy - pathology Humans Imaging, Three-Dimensional - methods Male Medical sciences Middle Aged Miscellaneous Ophthalmology Orbit diseases Orbital Diseases - etiology Orbital Diseases - pathology Patients Retrospective Studies Software Tissues Tomography Young Adult |
| title | Thyroid-Associated Periorbitopathy: Eyebrow Fat and Soft Tissue Expansion in Patients With Thyroid-Associated Orbitopathy |
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