Mutagenicity of ipriflavone in vivo and in vitro

► Mutagenicity of ipriflavone was evaluated through the micronucleus test. ► Ipriflavone was shown to be mutagenic and cytotoxic in vitro but not in vivo. ► Further studies are needed in order to validate the safety of ipriflavone as medicine. Ipriflavone (7-isopropoxy-isoflavone) is a semisynthetic...

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Veröffentlicht in:	Food and chemical toxicology 2012-03, Vol.50 (3-4), p.996-1000
Hauptverfasser:	Belcavello, Luciano, Vencioneck Dutra, Jean Carlos, de Freitas, Josivany Valério, Aranha, Ivar Pinheiro, Batitucci, Maria do Carmo Pimentel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences bone marrow cells cell proliferation Chemical mutagenesis cytotoxicity daidzein Dose-Response Relationship, Drug drugs Female Human lymphocytes Humans In Vitro Techniques Ipriflavone Isoflavones - toxicity lymphocytes Male Medical sciences Mice Micronucleus assay Micronucleus Tests Mutagenicity Mutagens - toxicity oral exposure osteoporosis postmenopause Toxicology women
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