Body mass index and bone loss among postmenopausal women: the 10-year follow-up of the OSTPRE cohort
Obesity protects against osteoporosis, but the magnitude of this association has been difficult to assess from cross-sectional or short term studies. We examined the time course of bone loss as a function of body mass index (BMI) in early and late postmenopausal women. Our study population ( n = 30...
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| Veröffentlicht in: | Journal of bone and mineral metabolism 2012-03, Vol.30 (2), p.208-216 |
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| creator | Saarelainen, Jarmo Kiviniemi, Vesa Kröger, Heikki Tuppurainen, Marjo Niskanen, Leo Jurvelin, Jukka Honkanen, Risto |
| description | Obesity protects against osteoporosis, but the magnitude of this association has been difficult to assess from cross-sectional or short term studies. We examined the time course of bone loss as a function of body mass index (BMI) in early and late postmenopausal women. Our study population (
n
= 300) was a random sample of the population-based Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) Study, Finland. We excluded women without complete BMD results, premenopausal women during the second bone densitometry and women who had used hormone replacement therapy, bisphosphonates or calcitonin. BMI along with femoral neck and spinal bone mineral density (BMD) were assessed three times by dual-energy X-ray absorptiometry during a mean follow-up of 10.5 years (SD 0.5). The mean baseline age was 53.6 years (SD 2.8), time since menopause 2.9 years (SD 4.3) and BMI 27.3 kg/m
2
(SD 4.4). The data was analyzed by linear mixed models. Thus, we were able to approximate the bone loss up to 20 postmenopausal years. To illustrate, a woman with a baseline BMI of 20 kg/m
2
became osteopenic 2 (spine) and 4 (femoral neck) years after menopause, while obesity (BMI of 30 kg/m
2
) delayed the incidence of osteopenia by 5 (spine) and 9 (femoral neck) years, respectively. The delay was due to high baseline BMD of the obese, while bone loss rate was similar for both lean and obese subjects. This lean versus obese difference may also be partly due to altered X-ray attenuation due to fat mass. |
| doi_str_mv | 10.1007/s00774-011-0305-5 |
| format | Article |
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n
= 300) was a random sample of the population-based Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) Study, Finland. We excluded women without complete BMD results, premenopausal women during the second bone densitometry and women who had used hormone replacement therapy, bisphosphonates or calcitonin. BMI along with femoral neck and spinal bone mineral density (BMD) were assessed three times by dual-energy X-ray absorptiometry during a mean follow-up of 10.5 years (SD 0.5). The mean baseline age was 53.6 years (SD 2.8), time since menopause 2.9 years (SD 4.3) and BMI 27.3 kg/m
2
(SD 4.4). The data was analyzed by linear mixed models. Thus, we were able to approximate the bone loss up to 20 postmenopausal years. To illustrate, a woman with a baseline BMI of 20 kg/m
2
became osteopenic 2 (spine) and 4 (femoral neck) years after menopause, while obesity (BMI of 30 kg/m
2
) delayed the incidence of osteopenia by 5 (spine) and 9 (femoral neck) years, respectively. The delay was due to high baseline BMD of the obese, while bone loss rate was similar for both lean and obese subjects. This lean versus obese difference may also be partly due to altered X-ray attenuation due to fat mass.</description><identifier>ISSN: 0914-8779</identifier><identifier>EISSN: 1435-5604</identifier><identifier>DOI: 10.1007/s00774-011-0305-5</identifier><identifier>PMID: 21938384</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Biological and medical sciences ; Body Height - physiology ; Body Mass Index ; Body Weight - physiology ; Bone Density - physiology ; Bone Resorption - physiopathology ; Cohort Studies ; Diseases of the osteoarticular system ; Female ; Finland - epidemiology ; Follow-Up Studies ; Humans ; Indexing in process ; Investigative techniques, diagnostic techniques (general aspects) ; Linear Models ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Original Article ; Orthopedics ; Osteoarticular system. Muscles ; Osteoporosis, Postmenopausal - epidemiology ; Osteoporosis, Postmenopausal - physiopathology ; Osteoporosis, Postmenopausal - prevention & control ; Osteoporosis. Osteomalacia. Paget disease ; Postmenopause - physiology ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Reference Values ; Risk Factors ; Time Factors</subject><ispartof>Journal of bone and mineral metabolism, 2012-03, Vol.30 (2), p.208-216</ispartof><rights>The Japanese Society for Bone and Mineral Research and Springer 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-f73da222c1d0b1a23bacb9371dd339ca67ee5a5e2dac750fd7693b04f81c851a3</citedby><cites>FETCH-LOGICAL-c487t-f73da222c1d0b1a23bacb9371dd339ca67ee5a5e2dac750fd7693b04f81c851a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00774-011-0305-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00774-011-0305-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25589612$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21938384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saarelainen, Jarmo</creatorcontrib><creatorcontrib>Kiviniemi, Vesa</creatorcontrib><creatorcontrib>Kröger, Heikki</creatorcontrib><creatorcontrib>Tuppurainen, Marjo</creatorcontrib><creatorcontrib>Niskanen, Leo</creatorcontrib><creatorcontrib>Jurvelin, Jukka</creatorcontrib><creatorcontrib>Honkanen, Risto</creatorcontrib><title>Body mass index and bone loss among postmenopausal women: the 10-year follow-up of the OSTPRE cohort</title><title>Journal of bone and mineral metabolism</title><addtitle>J Bone Miner Metab</addtitle><addtitle>J Bone Miner Metab</addtitle><description>Obesity protects against osteoporosis, but the magnitude of this association has been difficult to assess from cross-sectional or short term studies. We examined the time course of bone loss as a function of body mass index (BMI) in early and late postmenopausal women. Our study population (
n
= 300) was a random sample of the population-based Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) Study, Finland. We excluded women without complete BMD results, premenopausal women during the second bone densitometry and women who had used hormone replacement therapy, bisphosphonates or calcitonin. BMI along with femoral neck and spinal bone mineral density (BMD) were assessed three times by dual-energy X-ray absorptiometry during a mean follow-up of 10.5 years (SD 0.5). The mean baseline age was 53.6 years (SD 2.8), time since menopause 2.9 years (SD 4.3) and BMI 27.3 kg/m
2
(SD 4.4). The data was analyzed by linear mixed models. Thus, we were able to approximate the bone loss up to 20 postmenopausal years. To illustrate, a woman with a baseline BMI of 20 kg/m
2
became osteopenic 2 (spine) and 4 (femoral neck) years after menopause, while obesity (BMI of 30 kg/m
2
) delayed the incidence of osteopenia by 5 (spine) and 9 (femoral neck) years, respectively. The delay was due to high baseline BMD of the obese, while bone loss rate was similar for both lean and obese subjects. This lean versus obese difference may also be partly due to altered X-ray attenuation due to fat mass.</description><subject>Biological and medical sciences</subject><subject>Body Height - physiology</subject><subject>Body Mass Index</subject><subject>Body Weight - physiology</subject><subject>Bone Density - physiology</subject><subject>Bone Resorption - physiopathology</subject><subject>Cohort Studies</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Finland - epidemiology</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Indexing in process</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Linear Models</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteoarticular system. Muscles</subject><subject>Osteoporosis, Postmenopausal - epidemiology</subject><subject>Osteoporosis, Postmenopausal - physiopathology</subject><subject>Osteoporosis, Postmenopausal - prevention & control</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Postmenopause - physiology</subject><subject>Radiodiagnosis. Nmr imagery. 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Muscles</topic><topic>Osteoporosis, Postmenopausal - epidemiology</topic><topic>Osteoporosis, Postmenopausal - physiopathology</topic><topic>Osteoporosis, Postmenopausal - prevention & control</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Postmenopause - physiology</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Reference Values</topic><topic>Risk Factors</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saarelainen, Jarmo</creatorcontrib><creatorcontrib>Kiviniemi, Vesa</creatorcontrib><creatorcontrib>Kröger, Heikki</creatorcontrib><creatorcontrib>Tuppurainen, Marjo</creatorcontrib><creatorcontrib>Niskanen, Leo</creatorcontrib><creatorcontrib>Jurvelin, Jukka</creatorcontrib><creatorcontrib>Honkanen, Risto</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bone and mineral metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saarelainen, Jarmo</au><au>Kiviniemi, Vesa</au><au>Kröger, Heikki</au><au>Tuppurainen, Marjo</au><au>Niskanen, Leo</au><au>Jurvelin, Jukka</au><au>Honkanen, Risto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body mass index and bone loss among postmenopausal women: the 10-year follow-up of the OSTPRE cohort</atitle><jtitle>Journal of bone and mineral metabolism</jtitle><stitle>J Bone Miner Metab</stitle><addtitle>J Bone Miner Metab</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>30</volume><issue>2</issue><spage>208</spage><epage>216</epage><pages>208-216</pages><issn>0914-8779</issn><eissn>1435-5604</eissn><abstract>Obesity protects against osteoporosis, but the magnitude of this association has been difficult to assess from cross-sectional or short term studies. We examined the time course of bone loss as a function of body mass index (BMI) in early and late postmenopausal women. Our study population (
n
= 300) was a random sample of the population-based Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) Study, Finland. We excluded women without complete BMD results, premenopausal women during the second bone densitometry and women who had used hormone replacement therapy, bisphosphonates or calcitonin. BMI along with femoral neck and spinal bone mineral density (BMD) were assessed three times by dual-energy X-ray absorptiometry during a mean follow-up of 10.5 years (SD 0.5). The mean baseline age was 53.6 years (SD 2.8), time since menopause 2.9 years (SD 4.3) and BMI 27.3 kg/m
2
(SD 4.4). The data was analyzed by linear mixed models. Thus, we were able to approximate the bone loss up to 20 postmenopausal years. To illustrate, a woman with a baseline BMI of 20 kg/m
2
became osteopenic 2 (spine) and 4 (femoral neck) years after menopause, while obesity (BMI of 30 kg/m
2
) delayed the incidence of osteopenia by 5 (spine) and 9 (femoral neck) years, respectively. The delay was due to high baseline BMD of the obese, while bone loss rate was similar for both lean and obese subjects. This lean versus obese difference may also be partly due to altered X-ray attenuation due to fat mass.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>21938384</pmid><doi>10.1007/s00774-011-0305-5</doi><tpages>9</tpages></addata></record> |
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| subjects | Biological and medical sciences Body Height - physiology Body Mass Index Body Weight - physiology Bone Density - physiology Bone Resorption - physiopathology Cohort Studies Diseases of the osteoarticular system Female Finland - epidemiology Follow-Up Studies Humans Indexing in process Investigative techniques, diagnostic techniques (general aspects) Linear Models Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged Original Article Orthopedics Osteoarticular system. Muscles Osteoporosis, Postmenopausal - epidemiology Osteoporosis, Postmenopausal - physiopathology Osteoporosis, Postmenopausal - prevention & control Osteoporosis. Osteomalacia. Paget disease Postmenopause - physiology Radiodiagnosis. Nmr imagery. Nmr spectrometry Reference Values Risk Factors Time Factors |
| title | Body mass index and bone loss among postmenopausal women: the 10-year follow-up of the OSTPRE cohort |
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