Bisphenol A impairs insulin signaling and glucose homeostasis and decreases steroidogenesis in rat testis: An in vivo and in silico study

► BPA administration at low doses induces oxidative stress in rat testis. ► BPA decreases the levels of insulin signaling molecules in rat testis. ► BPA decreases the level of GLUT-2 and also impairs testicular steroidogenesis. ► BPA can directly interact with GLUT-2 and GLUT-8 and inhibit glucose t...

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Veröffentlicht in:	Food and chemical toxicology 2012-03, Vol.50 (3-4), p.1124-1133
Hauptverfasser:	D’Cruz, Shereen Cynthia, Jubendradass, Rajamanickam, Jayakanthan, Mannu, Rani, Sivaraj Judith Amala, Mathur, Premendu Prakash
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antioxidant activity Benzhydryl Compounds binding capacity Biological and medical sciences Bisphenol A body weight Catalase - metabolism cytochalasin B dose response glucose Glucose - metabolism Glucose Transport Proteins, Facilitative - metabolism Glucose Transporter Type 2 - metabolism Glucose transporter-2 glucose transporters glycolysis homeostasis Homeostasis - drug effects insulin Insulin - metabolism insulin receptors Insulin signaling Lipid Peroxidation - drug effects Male Medical sciences Phenols - pharmacology phosphatidylinositol 3-kinase Rats Rats, Wistar Signal Transduction - drug effects Steroidogenesis Steroids - biosynthesis Superoxide Dismutase - metabolism testes Testis Testis - drug effects Testis - enzymology Testis - metabolism testosterone Toxicology
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