Protection by [6]-shogaol against lipopolysaccharide-induced toxicity in murine astrocytes is related to production of brain-derived neurotrophic factor

► Primary cortical astrocytes were cultured from neonatal rats. ► [6]-Shogaol provided protection of astrocytes from the cytotoxicity induced by LPS. ► [6]-Shogaol showed anti-oxidant activity and BDNF increases in LPS-treated cultured astrocytes. ► The protective effects of [6]-shogaol are associat...

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Veröffentlicht in:	Food and chemical toxicology 2012-03, Vol.50 (3-4), p.597-602
Hauptverfasser:	Shim, Sehwan, Kim, Sokho, Kwon, Young-Bae, Kwon, Jungkee
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes Astrocytes - drug effects Astrocytes - metabolism B-lymphocytes Biological and medical sciences Blotting, Western Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Catechols - pharmacology Cell death cell viability Immunohistochemistry Lipopolysaccharide lipopolysaccharides Lipopolysaccharides - toxicity lymphoma Medical sciences Mice neurons neuroprotective effect neurotrophins Rats Rats, Sprague-Dawley Shogaol toxicity Toxicology Western blotting
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