Drug eluting stents based on Poly(ethylene carbonate): Optimization of the stent coating process

A reproducible spray-coating process for stents coated with Poly(ethylene carbonate), PEC, and Paclitaxel was developped. After expansion of the stents using a balloon catheter, confocal laser scanning micrographs of fluorescent dye loaded stents were made to demonstrate film homogeneity. The ablumi...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2012-04, Vol.80 (3), p.562-570
Hauptverfasser:	Bege, Nadja, Steinmüller, Sven Ole, Kalinowski, Marc, Reul, Regina, Klaus, Sebastian, Petersen, Holger, Curdy, Catherine, Janek, Jürgen, Kissel, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorbable Implants Biological and medical sciences Coated Materials, Biocompatible - chemistry Delayed-Action Preparations DES Diffusion Drug Carriers - chemistry Drug-Eluting Stents Ethylene Oxide - chemistry Excipients - chemistry General pharmacology Kinetics Late stent thrombosis Medical sciences Paclitaxel Paclitaxel - chemistry PEC Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylenes - chemistry Polymers - chemistry Spray-coating Thrombosis - chemically induced TOF-SIMS
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