Silencing or knocking out the Na Ca exchanger-3 (NCX3) impairs oligodendrocyte differentiation

Changes in intracellular [Ca(2+)](i) levels have been shown to influence developmental processes that accompany the transition of human oligodendrocyte precursor cells (OPCs) into mature myelinating oligodendrocytes and are required for the initiation of the myelination and re-myelination processes....

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Veröffentlicht in:	Cell death and differentiation 2012-04, Vol.19 (4), p.562-572
Hauptverfasser:	Boscia, F, D'Avanzo, C, Pannaccione, A, Secondo, A, Casamassa, A, Formisano, L, Guida, N, Sokolow, Sophie, Herchuelz, André, Annunziato, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Signaling - physiology Cell Differentiation - physiology Cell Line Gene Expression Regulation - physiology Gene Silencing Humans Mice Mice, Knockout Myelin Sheath - genetics Myelin Sheath - metabolism Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Neural Stem Cells - cytology Neural Stem Cells - metabolism Oligodendroglia - cytology Oligodendroglia - metabolism Protein Isoforms - biosynthesis Protein Isoforms - genetics Rats RNA, Messenger - biosynthesis RNA, Messenger - genetics Sodium-Calcium Exchanger - biosynthesis Sodium-Calcium Exchanger - genetics
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